IL2 signaling events mediated by PI3K Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.045 0.306 -9999.0 0.0 -0.869 7.0 7.0 UGCG 0.016 0.053 -9999.0 0.0 -9999.0 0.0 0.0 AKT1/mTOR/p70S6K/Hsp90/TERT 0.001 0.237 -9999.0 0.0 -0.543 8.0 8.0 mol:GTP 0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:glucosylceramide 0.016 0.053 -9999.0 0.0 -9999.0 0.0 0.0 mol:DAG -0.022 0.124 -9999.0 0.0 -1.019 1.0 1.0 CaM/Ca2+/Calcineurin A alpha-beta B1 -0.124 0.242 -9999.0 0.0 -0.616 12.0 12.0 FRAP1 -0.05 0.36 -9999.0 0.0 -0.765 12.0 12.0 FOXO3 -0.041 0.333 -9999.0 0.0 -0.755 11.0 11.0 AKT1 -0.064 0.371 -9999.0 0.0 -0.858 11.0 11.0 GAB2 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SMPD1 0.016 0.053 -9999.0 0.0 -9999.0 0.0 0.0 SGMS1 0.001 0.103 -9999.0 0.0 -0.414 3.0 3.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.009 0.129 -9999.0 0.0 -0.434 6.0 6.0 CALM1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation 0.003 0.142 -9999.0 0.0 -0.336 6.0 6.0 EIF3A 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.01 0.15 -9999.0 0.0 -0.502 6.0 6.0 RPS6KB1 0.024 0.052 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingomyelin -0.022 0.124 -9999.0 0.0 -1.019 1.0 1.0 natural killer cell activation 0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 JAK3 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.035 0.195 -9999.0 0.0 -0.679 6.0 6.0 JAK1 -0.017 0.168 -9999.0 0.0 -0.708 4.0 4.0 NFKB1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.076 0.41 -9999.0 0.0 -1.047 10.0 10.0 MYB 0.015 0.182 -9999.0 0.0 -1.364 1.0 1.0 IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.053 0.332 -9999.0 0.0 -0.776 10.0 10.0 40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 0.041 0.06 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.048 0.316 -9999.0 0.0 -0.704 11.0 11.0 Rac1/GDP 0.003 0.119 -9999.0 0.0 -0.407 5.0 5.0 T cell proliferation -0.041 0.287 -9999.0 0.0 -0.669 10.0 10.0 SHC1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.02 0.001 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of cyclin-dependent protein kinase activity 0.006 0.012 -9999.0 0.0 -0.051 3.0 3.0 PRKCZ -0.046 0.305 -9999.0 0.0 -0.713 10.0 10.0 NF kappa B1 p50/RelA -0.118 0.242 -9999.0 0.0 -0.659 10.0 10.0 IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.067 0.335 -9999.0 0.0 -0.9 8.0 8.0 HSP90AA1 0.005 0.089 -9999.0 0.0 -0.523 2.0 2.0 RELA 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL2RA -0.091 0.251 -9999.0 0.0 -0.647 12.0 12.0 IL2RB -0.047 0.217 -9999.0 0.0 -0.71 7.0 7.0 TERT 0.002 0.106 -9999.0 0.0 -0.616 2.0 2.0 E2F1 0.025 0.077 -9999.0 0.0 -0.463 1.0 1.0 SOS1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RPS6 0.012 0.064 -9999.0 0.0 -0.523 1.0 1.0 mol:cAMP -0.003 0.006 0.024 3.0 -9999.0 0.0 3.0 PTPN11 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IL2RG 0.0 0.109 -9999.0 0.0 -0.519 3.0 3.0 actin cytoskeleton organization -0.041 0.287 -9999.0 0.0 -0.669 10.0 10.0 GRB2 0.01 0.085 -9999.0 0.0 -0.708 1.0 1.0 IL2 0.003 0.12 -9999.0 0.0 -0.708 2.0 2.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP 0.014 0.117 -9999.0 0.0 -0.387 5.0 5.0 LCK -0.1 0.257 -9999.0 0.0 -0.615 14.0 14.0 BCL2 -0.049 0.354 -9999.0 0.0 -0.805 11.0 11.0