BMP receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BMP7/BMPR2/BMPR1A-1B/FS -0.024 0.126 -9999.0 0.0 -0.378 1.0 1.0 SMAD6-7/SMURF1 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NOG 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD9 0.021 0.03 -9999.0 0.0 -9999.0 0.0 0.0 SMAD4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD5 -0.005 0.079 -9999.0 0.0 -9999.0 0.0 0.0 BMP7/USAG1 -0.192 0.188 -9999.0 0.0 -0.32 10.0 10.0 SMAD5/SKI 0.003 0.077 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1 0.028 0.02 -9999.0 0.0 -9999.0 0.0 0.0 BMP2 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 SMAD1/SMAD1/SMAD4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1B -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 BMPR1A-1B/BAMBI -0.002 0.085 -9999.0 0.0 -0.226 2.0 2.0 AHSG -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 CER1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CER1 -0.014 0.093 -9999.0 0.0 -0.207 3.0 3.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA 0.021 0.074 -9999.0 0.0 -0.231 1.0 1.0 BMP2-4 (homodimer) -0.03 0.109 -9999.0 0.0 -0.256 3.0 3.0 RGMB 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/BMPR2/BMPR1A-1B -0.029 0.1 -9999.0 0.0 -0.198 3.0 3.0 RGMA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMURF1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP 0.007 0.071 -9999.0 0.0 -0.225 1.0 1.0 BMP2-4/USAG1 -0.155 0.114 -9999.0 0.0 -0.216 12.0 12.0 SMAD6/SMURF1/SMAD5 0.003 0.077 -9999.0 0.0 -9999.0 0.0 0.0 SOSTDC1 -0.222 0.187 -9999.0 0.0 -0.365 10.0 10.0 BMP7/BMPR2/BMPR1A-1B -0.019 0.127 -9999.0 0.0 -0.267 3.0 3.0 SKI 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 (homodimer) -0.08 0.165 -9999.0 0.0 -0.364 4.0 4.0 HFE2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZFYVE16 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRD -0.014 0.093 -9999.0 0.0 -0.207 3.0 3.0 SMAD5/SMAD5/SMAD4 0.003 0.077 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/TAB family 0.03 0.062 -9999.0 0.0 -9999.0 0.0 0.0 BMP7 (homodimer) -0.064 0.165 -9999.0 0.0 -0.407 3.0 3.0 NUP214 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/FETUA -0.063 0.128 -9999.0 0.0 -0.252 5.0 5.0 SMAD1/SKI 0.036 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/FETUA -0.028 0.132 -9999.0 0.0 -0.281 3.0 3.0 MAP3K7IP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GREM1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 BMPR2 (homodimer) 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GADD34/PP1CA 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A-1B (homodimer) 0.003 0.073 -9999.0 0.0 -0.279 1.0 1.0 CHRDL1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 ENDOFIN/SMAD1 0.036 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6-7/SMURF1/SMAD1 0.048 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6/SMURF1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAMBI -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 SMURF2 -0.033 0.126 -9999.0 0.0 -0.365 2.0 2.0 BMP2-4/CHRDL1 -0.03 0.105 -9999.0 0.0 -0.226 3.0 3.0 BMP2-4/GREM1 -0.03 0.105 -9999.0 0.0 -0.226 3.0 3.0 SMAD7 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD8A/SMAD8A/SMAD4 0.027 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMAD6 0.036 0.019 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/SMAD6 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP7 -0.064 0.165 -9999.0 0.0 -0.408 3.0 3.0 BMP6 -0.08 0.166 -9999.0 0.0 -0.365 4.0 4.0 MAP3K7IP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 0.017 0.064 -9999.0 0.0 -9999.0 0.0 0.0 PPM1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMURF2 0.021 0.057 -9999.0 0.0 -9999.0 0.0 0.0 SMAD7/SMURF1 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSPL 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP1CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XIAP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R15A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/FS 0.004 0.084 -9999.0 0.0 -0.22 1.0 1.0 CHRD 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM 0.008 0.074 -9999.0 0.0 -0.239 1.0 1.0 BMP4 -0.038 0.14 -9999.0 0.0 -0.408 2.0 2.0 FST -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 BMP2-4/NOG -0.014 0.093 -9999.0 0.0 -0.226 2.0 2.0 BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.01 0.12 -9999.0 0.0 -0.378 1.0 1.0