HIV-1 Nef: Negative effector of Fas and TNF-alpha Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BAG4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Caspase 8 (4 units) -0.028 0.097 -9999.0 0.0 -0.225 1.0 1.0 NEF -0.027 0.056 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIA -0.004 0.037 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.071 0.17 -9999.0 0.0 -0.357 4.0 4.0 CYCS -0.044 0.1 -9999.0 0.0 -0.228 1.0 1.0 RIPK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD247 -0.062 0.153 -9999.0 0.0 -0.427 2.0 2.0 MAP2K7 -0.028 0.093 -9999.0 0.0 -9999.0 0.0 0.0 protein ubiquitination -0.02 0.1 -9999.0 0.0 -0.264 1.0 1.0 CRADD -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 DAXX 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FAS -0.033 0.126 -9999.0 0.0 -0.365 2.0 2.0 BID -0.052 0.105 -9999.0 0.0 -0.224 2.0 2.0 NF-kappa-B/RelA/I kappa B alpha -0.029 0.104 -9999.0 0.0 -0.199 1.0 1.0 TRADD 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K5 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 CFLAR 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FADD 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF-kappa-B/RelA/I kappa B alpha/ubiquitin -0.029 0.105 -9999.0 0.0 -0.2 1.0 1.0 MAPK8 -0.03 0.088 -9999.0 0.0 -9999.0 0.0 0.0 APAF1 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 TRAF1 -0.027 0.111 -9999.0 0.0 -0.321 2.0 2.0 TRAF2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.044 0.11 -9999.0 0.0 -0.223 3.0 3.0 TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD -0.02 0.088 -9999.0 0.0 -9999.0 0.0 0.0 CHUK -0.023 0.106 -9999.0 0.0 -0.285 1.0 1.0 FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.009 0.075 -9999.0 0.0 -9999.0 0.0 0.0 TCRz/NEF -0.07 0.149 -9999.0 0.0 -0.268 5.0 5.0 TNF -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 FASLG -0.103 0.208 -9999.0 0.0 -0.443 4.0 4.0 NFKB1 -0.025 0.084 -9999.0 0.0 -0.316 1.0 1.0 TNFR1A/BAG4/TNF-alpha 0.014 0.062 -9999.0 0.0 -0.226 1.0 1.0 CASP6 -0.015 0.078 -9999.0 0.0 -9999.0 0.0 0.0 CASP7 -0.093 0.19 -9999.0 0.0 -0.398 4.0 4.0 RELA -0.004 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CASP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 -0.093 0.19 -9999.0 0.0 -0.398 4.0 4.0 TNFRSF1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP9 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K14 -0.022 0.104 -9999.0 0.0 -0.316 1.0 1.0 APAF-1/Caspase 9 -0.104 0.123 -9999.0 0.0 -0.336 3.0 3.0 BCL2 -0.031 0.088 -9999.0 0.0 -9999.0 0.0 0.0