Signaling events mediated by HDAC Class III Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations EP300 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 induction of apoptosis 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of S phase of mitotic cell cycle -0.015 0.029 -9999.0 0.0 -0.126 1.0 1.0 CDKN1A -0.027 0.132 -9999.0 0.0 -0.531 1.0 1.0 KAT2B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAX 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOXO3 -0.006 0.001 -9999.0 0.0 -9999.0 0.0 0.0 FOXO1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 FOXO4 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to UV -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Lysophosphatidic acid 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYOD1 -0.008 0.072 -9999.0 0.0 -0.287 1.0 1.0 PPARGC1A -0.027 0.111 -9999.0 0.0 -0.321 2.0 2.0 FHL2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to nutrient levels 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU70/SIRT1 0.026 0.028 -9999.0 0.0 -9999.0 0.0 0.0 HIST2H4A 0.015 0.029 0.127 1.0 -9999.0 0.0 1.0 SIRT1/FOXO3a 0.01 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1 0.021 0.04 0.176 1.0 -9999.0 0.0 1.0 response to hypoxia -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/MEF2D/HDAC4 0.034 0.026 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/Histone H1b 0.03 0.029 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.033 0.025 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/PGC1A -0.0 0.071 -9999.0 0.0 -0.176 2.0 2.0 p53/SIRT1 0.008 0.1 0.34 1.0 -0.214 1.0 2.0 SIRT1/FOXO4 0.03 0.029 -9999.0 0.0 -9999.0 0.0 0.0 FOXO1/FHL2/SIRT1 0.016 0.039 -9999.0 0.0 -9999.0 0.0 0.0 HIST1H1E 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/p300 0.026 0.028 -9999.0 0.0 -9999.0 0.0 0.0 muscle cell differentiation -0.004 0.067 0.234 1.0 -9999.0 0.0 1.0 TP53 -0.0 0.092 0.176 1.0 -0.323 1.0 2.0 KU70/SIRT1/BAX 0.034 0.026 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MEF2D 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HIV-1 Tat/SIRT1 0.026 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ACSS2 0.025 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SIRT1/PCAF/MYOD 0.005 0.067 -9999.0 0.0 -0.234 1.0 1.0