amb2 Integrin signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations alphaM/beta2 Integrin/proMMP-2 -0.031 0.113 -9999.0 0.0 -0.257 3.0 3.0 alphaM/beta2 Integrin/GPIbA -0.031 0.113 -9999.0 0.0 -0.257 3.0 3.0 alphaM/beta2 Integrin/proMMP-9 -0.097 0.152 -9999.0 0.0 -0.283 5.0 5.0 PLAUR 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HMGB1 0.01 0.016 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/Talin -0.031 0.113 -9999.0 0.0 -0.257 3.0 3.0 AGER 0.01 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 SELPLG -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 mol:LDL -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/RAGE/HMGB1 -0.028 0.113 -9999.0 0.0 -0.287 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MMP9 -0.101 0.173 -9999.0 0.0 -0.356 5.0 5.0 CYR61 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 TLN1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.048 0.075 -9999.0 0.0 -0.22 2.0 2.0 RHOA -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 P-selectin oligomer -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 MYH2 -0.029 0.089 -9999.0 0.0 -9999.0 0.0 0.0 MST1R -0.033 0.126 -9999.0 0.0 -0.365 2.0 2.0 leukocyte activation during inflammatory response -0.033 0.102 -9999.0 0.0 -0.203 4.0 4.0 APOB -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 complement component iC3b receptor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MMP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JAM3 -0.038 0.14 -9999.0 0.0 -0.408 2.0 2.0 GP1BA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/CTGF -0.044 0.154 -9999.0 0.0 -0.329 3.0 3.0 alphaM/beta2 Integrin -0.02 0.086 -9999.0 0.0 -0.254 1.0 1.0 JAM3 homodimer -0.038 0.14 -9999.0 0.0 -0.407 2.0 2.0 ICAM2 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 ICAM1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 phagocytosis triggered by activation of immune response cell surface activating receptor -0.019 0.085 -9999.0 0.0 -0.252 1.0 1.0 cell adhesion -0.031 0.113 -9999.0 0.0 -0.256 3.0 3.0 NFKB1 -0.039 0.123 -9999.0 0.0 -0.255 2.0 2.0 THY1 -0.038 0.14 -9999.0 0.0 -0.408 2.0 2.0 RhoA/GDP -0.003 0.056 -9999.0 0.0 -0.219 1.0 1.0 Lipoprotein(a) 0.004 0.061 -9999.0 0.0 -0.233 1.0 1.0 alphaM/beta2 Integrin/LRP/tPA -0.029 0.143 -9999.0 0.0 -0.5 1.0 1.0 IL6 -0.06 0.173 -9999.0 0.0 -0.429 2.0 2.0 ITGB2 -0.063 0.151 -9999.0 0.0 -0.374 3.0 3.0 elevation of cytosolic calcium ion concentration -0.056 0.143 -9999.0 0.0 -0.25 5.0 5.0 alphaM/beta2 Integrin/JAM2/JAM3 -0.045 0.117 -9999.0 0.0 -0.213 5.0 5.0 JAM2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/ICAM1 -0.046 0.11 -9999.0 0.0 -0.274 1.0 1.0 alphaM/beta2 Integrin/uPA/Plg -0.068 0.164 -9999.0 0.0 -0.293 5.0 5.0 RhoA/GTP -0.015 0.075 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of phagocytosis -0.085 0.159 -9999.0 0.0 -0.346 3.0 3.0 Ron/MSP -0.03 0.109 -9999.0 0.0 -0.256 3.0 3.0 alphaM/beta2 Integrin/uPAR/uPA -0.055 0.144 -9999.0 0.0 -0.251 5.0 5.0 alphaM/beta2 Integrin/uPAR -0.031 0.113 -9999.0 0.0 -0.257 3.0 3.0 PLAU -0.059 0.155 -9999.0 0.0 -0.379 3.0 3.0 PLAT -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 actin filament polymerization -0.028 0.087 -9999.0 0.0 -9999.0 0.0 0.0 MST1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 alphaM/beta2 Integrin/lipoprotein(a) -0.029 0.105 -9999.0 0.0 -0.204 4.0 4.0 TNF -0.041 0.132 -9999.0 0.0 -0.326 1.0 1.0 RAP1B -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 alphaM/beta2 Integrin/uPA -0.072 0.156 -9999.0 0.0 -0.283 5.0 5.0 fibrinolysis -0.069 0.163 -9999.0 0.0 -0.291 5.0 5.0 HCK -0.106 0.181 -9999.0 0.0 -0.373 5.0 5.0 dendritic cell antigen processing and presentation -0.019 0.085 -9999.0 0.0 -0.252 1.0 1.0 VTN 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/CYR61 -0.043 0.122 -9999.0 0.0 -0.247 4.0 4.0 LPA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell migration -0.081 0.139 -9999.0 0.0 -0.251 5.0 5.0 FN1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 alphaM/beta2 Integrin/Thy1 -0.063 0.126 -9999.0 0.0 -0.243 5.0 5.0 MPO 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KNG1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP -0.008 0.075 -9999.0 0.0 -0.203 2.0 2.0 ROCK1 -0.008 0.072 -9999.0 0.0 -9999.0 0.0 0.0 ELA2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLG -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 CTGF -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 alphaM/beta2 Integrin/Hck -0.097 0.189 -9999.0 0.0 -0.4 4.0 4.0 ITGAM -0.011 0.081 -9999.0 0.0 -0.317 1.0 1.0 alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.037 0.135 -9999.0 0.0 -0.278 3.0 3.0 HP -0.033 0.126 -9999.0 0.0 -0.365 2.0 2.0 leukocyte adhesion -0.058 0.118 -9999.0 0.0 -0.287 2.0 2.0 SELP -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0