Signaling events mediated by HDAC Class I Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations NF kappa B/RelA 0.02 0.059 -9999.0 0.0 -9999.0 0.0 0.0 Ran/GTP/Exportin 1/HDAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA/I kappa B alpha 0.033 0.039 -9999.0 0.0 -9999.0 0.0 0.0 SUMO1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZFPM1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 NPC/RanGAP1/SUMO1/Ubc9 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FKBP3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Histones 0.04 0.028 -9999.0 0.0 -9999.0 0.0 0.0 YY1/LSF 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMG5 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAN 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 I kappa B alpha/HDAC3 0.022 0.038 -9999.0 0.0 -9999.0 0.0 0.0 I kappa B alpha/HDAC1 0.025 0.03 -9999.0 0.0 -9999.0 0.0 0.0 SAP18 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.026 0.033 -9999.0 0.0 -9999.0 0.0 0.0 HDAC1/Smad7 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RANGAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC3/TR2 0.025 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NuRD/MBD3 Complex 0.0 0.094 -9999.0 0.0 -0.256 1.0 1.0 NF kappa B1 p50/RelA 0.029 0.032 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:23225 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GATA2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GATA1 -0.038 0.14 -9999.0 0.0 -0.408 2.0 2.0 Mad/Max 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NuRD/MBD3 Complex/GATA1/Fog1 -0.012 0.116 -9999.0 0.0 -0.288 2.0 2.0 RBBP7 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NPC 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RBBP4 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 MAX 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:9972 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIA 0.018 0.033 -9999.0 0.0 -9999.0 0.0 0.0 KAT2B 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIN3/HDAC complex 0.029 0.041 -9999.0 0.0 -9999.0 0.0 0.0 SIN3 complex 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMURF1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CHD3 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 SAP30 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:23636 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCOR1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YY1/HDAC3 0.029 0.027 -9999.0 0.0 -9999.0 0.0 0.0 YY1/HDAC2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YY1/HDAC1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NuRD/MBD2 Complex (MeCP1) 0.0 0.094 -9999.0 0.0 -0.256 1.0 1.0 PPARG 0.017 0.051 -9999.0 0.0 -9999.0 0.0 0.0 HDAC8/hEST1B 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 UBE2I 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 beta TrCP1/SCF ubiquitin ligase complex 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFRSF1A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC3/SMRT (N-CoR2) 0.025 0.03 -9999.0 0.0 -9999.0 0.0 0.0 MBD3L2 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 ubiquitin-dependent protein catabolic process 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NuRD/MBD3/MBD3L2 Complex -0.006 0.105 -9999.0 0.0 -0.27 1.0 1.0 HDAC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC3 0.018 0.033 -9999.0 0.0 -9999.0 0.0 0.0 HDAC2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YY1 0.021 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC8 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD7 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCOR2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MXD1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 0.008 0.061 -9999.0 0.0 -0.228 1.0 1.0 NFKB1 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 EntrezGene:8021 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RANBP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YY1/LSF/HDAC1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YY1/SAP30/HDAC1 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EP300 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer non-phopshorylated) 0.008 0.061 -9999.0 0.0 -0.228 1.0 1.0 proteasomal ubiquitin-dependent protein catabolic process 0.018 0.033 -9999.0 0.0 -9999.0 0.0 0.0 histone deacetylation 0.0 0.094 -9999.0 0.0 -0.254 1.0 1.0 STAT3 (dimer non-phopshorylated)/HDAC3 0.02 0.05 -9999.0 0.0 -9999.0 0.0 0.0 nuclear export -0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GATAD2B 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GATAD2A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GATA2/HDAC3 0.025 0.03 -9999.0 0.0 -9999.0 0.0 0.0 GATA1/HDAC1 -0.016 0.099 -9999.0 0.0 -0.279 2.0 2.0 GATA1/HDAC3 -0.003 0.077 -9999.0 0.0 -9999.0 0.0 0.0 CHD4 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNF-alpha/TNFR1A 0.003 0.073 -9999.0 0.0 -0.279 1.0 1.0 SIN3/HDAC complex/Mad/Max 0.034 0.037 -9999.0 0.0 -9999.0 0.0 0.0 NuRD Complex 0.004 0.103 -9999.0 0.0 -0.27 1.0 1.0 positive regulation of chromatin silencing 0.038 0.028 -9999.0 0.0 -9999.0 0.0 0.0 SIN3B 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MTA2 -0.048 0.131 -9999.0 0.0 -0.321 3.0 3.0 SIN3A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XPO1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SUMO1/HDAC1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HDAC complex 0.027 0.044 -9999.0 0.0 -9999.0 0.0 0.0 GATA1/Fog1 -0.034 0.117 -9999.0 0.0 -0.279 3.0 3.0 FKBP25/HDAC1/HDAC2 0.03 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 negative regulation of cell growth 0.034 0.037 -9999.0 0.0 -9999.0 0.0 0.0 NuRD/MBD2/PRMT5 Complex 0.0 0.094 -9999.0 0.0 -0.256 1.0 1.0 Ran/GTP/Exportin 1 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B/RelA/I kappa B alpha 0.029 0.039 -9999.0 0.0 -9999.0 0.0 0.0 SIN3/HDAC complex/NCoR1 0.031 0.041 -9999.0 0.0 -9999.0 0.0 0.0 TFCP2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NR2C1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MBD3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MBD2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0