Plasma membrane estrogen receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GNB1/GNG2 0.014 0.056 -9999.0 0.0 -9999.0 0.0 0.0 ER alpha/Gai/GDP/Gbeta gamma -0.004 0.102 -9999.0 0.0 -0.255 2.0 2.0 AKT1 -0.061 0.22 -9999.0 0.0 -0.637 2.0 2.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E2/ER alpha (dimer)/PELP1/Src/PI3K -0.059 0.225 -9999.0 0.0 -0.649 2.0 2.0 mol:Ca2+ -0.039 0.141 -9999.0 0.0 -0.324 3.0 3.0 IGF1R 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E2/ER alpha (dimer)/Striatin -0.041 0.09 -9999.0 0.0 -0.174 5.0 5.0 SHC1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis 0.057 0.211 0.611 2.0 -9999.0 0.0 2.0 RhoA/GTP -0.039 0.073 -9999.0 0.0 -0.248 1.0 1.0 E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.047 0.09 -9999.0 0.0 -0.265 2.0 2.0 regulation of stress fiber formation -0.001 0.073 0.195 1.0 -9999.0 0.0 1.0 E2/ERA-ERB (dimer) -0.004 0.064 -9999.0 0.0 -0.174 2.0 2.0 KRAS 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G13/GTP -0.017 0.076 -9999.0 0.0 -0.173 3.0 3.0 pseudopodium formation 0.001 0.073 -9999.0 0.0 -0.195 1.0 1.0 E2/ER alpha (dimer)/PELP1 -0.02 0.084 -9999.0 0.0 -0.194 3.0 3.0 GRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNG2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAO1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:NO -0.027 0.137 -9999.0 0.0 -0.359 2.0 2.0 E2/ER beta (dimer) 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.044 0.087 -9999.0 0.0 -0.257 2.0 2.0 mol:NADP -0.027 0.137 -9999.0 0.0 -0.359 2.0 2.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.041 0.145 -9999.0 0.0 -0.336 3.0 3.0 IGF-1R heterotetramer 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCB1 -0.035 0.125 -9999.0 0.0 -0.288 3.0 3.0 PLCB2 -0.027 0.107 -9999.0 0.0 -0.277 2.0 2.0 IGF1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 mol:L-citrulline -0.027 0.137 -9999.0 0.0 -0.359 2.0 2.0 RHOA -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 Gai/GDP 0.019 0.043 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ESR2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAQ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ESR1 -0.027 0.111 -9999.0 0.0 -0.321 2.0 2.0 Gq family/GDP/Gbeta gamma -0.001 0.067 -9999.0 0.0 -9999.0 0.0 0.0 E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.005 0.074 -9999.0 0.0 -9999.0 0.0 0.0 E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.047 0.09 -9999.0 0.0 -0.265 2.0 2.0 GNAZ 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E2/ER alpha (dimer) -0.018 0.076 -9999.0 0.0 -0.219 2.0 2.0 STRN -0.048 0.131 -9999.0 0.0 -0.321 3.0 3.0 GNAL -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 PELP1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 MAPK11 0.005 0.046 -9999.0 0.0 -0.174 1.0 1.0 GNAI2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 HBEGF -0.018 0.102 -9999.0 0.0 -0.294 1.0 1.0 cAMP biosynthetic process -0.011 0.058 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.002 0.098 -9999.0 0.0 -0.238 2.0 2.0 PI3K 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNB1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G13/GDP/Gbeta gamma -0.01 0.09 -9999.0 0.0 -0.214 2.0 2.0 SOS1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.044 0.074 -9999.0 0.0 -0.215 2.0 2.0 Gs family/GTP -0.007 0.06 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:2778 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP 0.018 0.043 -9999.0 0.0 -9999.0 0.0 0.0 vasodilation -0.025 0.133 -9999.0 0.0 -0.346 2.0 2.0 mol:DAG -0.041 0.145 -9999.0 0.0 -0.336 3.0 3.0 Gs family/GDP/Gbeta gamma -0.04 0.071 -9999.0 0.0 -0.208 2.0 2.0 MSN -0.0 0.077 -9999.0 0.0 -0.208 1.0 1.0 Gq family/GTP -0.021 0.09 -9999.0 0.0 -0.235 2.0 2.0 mol:PI-3-4-5-P3 -0.056 0.218 -9999.0 0.0 -0.627 2.0 2.0 NRAS -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 mol:E2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell adhesion 0.025 0.133 0.346 2.0 -9999.0 0.0 2.0 GRB2/SOS1 0.022 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP -0.024 0.103 -9999.0 0.0 -0.224 3.0 3.0 NOS3 -0.029 0.142 -9999.0 0.0 -0.374 2.0 2.0 GNA11 -0.038 0.14 -9999.0 0.0 -0.408 2.0 2.0 MAPKKK cascade -0.07 0.174 -9999.0 0.0 -0.439 2.0 2.0 E2/ER alpha (dimer)/PELP1/Src -0.015 0.114 -9999.0 0.0 -0.279 2.0 2.0 ruffle organization 0.001 0.073 -9999.0 0.0 -0.195 1.0 1.0 ROCK2 -0.006 0.083 -9999.0 0.0 -0.229 1.0 1.0 GNA14 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 GNA15 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 MMP9 -0.043 0.121 -9999.0 0.0 -0.358 1.0 1.0 MMP2 0.007 0.093 -9999.0 0.0 -9999.0 0.0 0.0