IL23-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CCL2 -0.338 0.571 -9999.0 0.0 -1.317 3.0 3.0 IL23A -0.371 0.569 -9999.0 0.0 -1.194 4.0 4.0 NF kappa B1 p50/RelA/I kappa B alpha -0.345 0.562 -9999.0 0.0 -1.167 4.0 4.0 positive regulation of T cell mediated cytotoxicity -0.393 0.662 -9999.0 0.0 -1.367 4.0 4.0 ITGA3 -0.33 0.54 -9999.0 0.0 -1.125 4.0 4.0 IL17F -0.191 0.36 -9999.0 0.0 -0.758 3.0 3.0 IL12B -0.015 0.096 -9999.0 0.0 -0.358 1.0 1.0 STAT1 (dimer) -0.381 0.613 -9999.0 0.0 -1.29 4.0 4.0 CD4 -0.317 0.529 -9999.0 0.0 -1.098 4.0 4.0 IL23 -0.363 0.555 -9999.0 0.0 -1.166 4.0 4.0 IL23R -0.164 0.427 -9999.0 0.0 -1.271 2.0 2.0 IL1B -0.406 0.629 -9999.0 0.0 -1.354 4.0 4.0 T-helper cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL24 -0.317 0.529 -9999.0 0.0 -1.098 4.0 4.0 TYK2 0.005 0.025 -9999.0 0.0 -9999.0 0.0 0.0 STAT4 -0.054 0.143 -9999.0 0.0 -0.35 3.0 3.0 STAT3 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 IL18RAP -0.054 0.142 -9999.0 0.0 -0.346 3.0 3.0 IL12RB1 0.005 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12Rbeta1/TYK2 0.007 0.032 -9999.0 0.0 -9999.0 0.0 0.0 IL23R/JAK2 -0.157 0.413 -9999.0 0.0 -1.212 2.0 2.0 positive regulation of chronic inflammatory response -0.393 0.662 -9999.0 0.0 -1.367 4.0 4.0 natural killer cell activation 0.01 0.026 0.075 2.0 -9999.0 0.0 2.0 JAK2 0.007 0.035 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 -0.007 0.081 -9999.0 0.0 -0.32 1.0 1.0 RELA 0.013 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of dendritic cell antigen processing and presentation -0.341 0.52 -9999.0 0.0 -1.086 4.0 4.0 ALOX12B -0.317 0.529 -9999.0 0.0 -1.098 4.0 4.0 CXCL1 -0.467 0.63 -9999.0 0.0 -1.213 6.0 6.0 T cell proliferation -0.393 0.662 -9999.0 0.0 -1.367 4.0 4.0 NFKBIA 0.013 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IL17A -0.14 0.291 -9999.0 0.0 -0.57 3.0 3.0 PI3K -0.341 0.584 -9999.0 0.0 -1.21 4.0 4.0 IFNG -0.008 0.058 0.151 1.0 -0.093 2.0 3.0 STAT3 (dimer) -0.316 0.552 -9999.0 0.0 -1.146 4.0 4.0 IL18R1 -0.033 0.129 -9999.0 0.0 -0.371 2.0 2.0 IL23/IL23R/JAK2/TYK2/SOCS3 -0.207 0.388 -9999.0 0.0 -0.882 3.0 3.0 IL18/IL18R -0.047 0.139 -9999.0 0.0 -0.283 4.0 4.0 macrophage activation -0.021 0.018 -9999.0 0.0 -0.045 3.0 3.0 TNF -0.362 0.574 -9999.0 0.0 -1.191 4.0 4.0 STAT3/STAT4 -0.381 0.592 -9999.0 0.0 -1.272 4.0 4.0 STAT4 (dimer) -0.402 0.621 -9999.0 0.0 -1.323 4.0 4.0 IL18 -0.006 0.079 -9999.0 0.0 -0.313 1.0 1.0 IL19 -0.317 0.529 -9999.0 0.0 -1.098 4.0 4.0 STAT5A (dimer) -0.372 0.62 -9999.0 0.0 -1.29 4.0 4.0 STAT1 -0.012 0.102 -9999.0 0.0 -0.408 1.0 1.0 SOCS3 -0.006 0.081 -9999.0 0.0 -0.321 1.0 1.0 CXCL9 -0.388 0.568 -9999.0 0.0 -1.182 4.0 4.0 MPO -0.317 0.529 -9999.0 0.0 -1.098 4.0 4.0 positive regulation of humoral immune response -0.393 0.662 -9999.0 0.0 -1.367 4.0 4.0 IL23/IL23R/JAK2/TYK2 -0.447 0.792 -9999.0 0.0 -1.579 4.0 4.0 IL6 -0.353 0.577 -9999.0 0.0 -1.216 4.0 4.0 STAT5A 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL2 -0.01 0.106 -9999.0 0.0 -0.419 1.0 1.0 positive regulation of tyrosine phosphorylation of STAT protein 0.01 0.026 0.075 2.0 -9999.0 0.0 2.0 CD3E -0.317 0.529 -9999.0 0.0 -1.098 4.0 4.0 keratinocyte proliferation -0.393 0.662 -9999.0 0.0 -1.367 4.0 4.0 NOS2 -0.324 0.528 -9999.0 0.0 -1.104 4.0 4.0