Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.017 0.062 -9999.0 0.0 -0.174 2.0 2.0 epithelial cell differentiation 0.0 0.075 -9999.0 0.0 -0.153 2.0 2.0 CYFIP2 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.044 0.072 -9999.0 0.0 -0.207 1.0 1.0 EGFR -0.036 0.115 -9999.0 0.0 -0.268 3.0 3.0 EPHA2 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.017 0.084 0.163 2.0 -9999.0 0.0 2.0 CTNNB1 -0.018 0.11 -9999.0 0.0 -0.309 2.0 2.0 ABI1/Sra1/Nap1 0.035 0.04 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.037 0.118 -9999.0 0.0 -0.384 1.0 1.0 CTNND1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.016 0.083 0.161 2.0 -9999.0 0.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.082 0.161 2.0 -9999.0 0.0 2.0 EGF -0.056 0.125 -9999.0 0.0 -0.235 5.0 5.0 NCKAP1 0.012 0.051 -9999.0 0.0 -0.186 1.0 1.0 AQP3 -0.027 0.07 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization 0.0 0.075 -9999.0 0.0 -0.153 2.0 2.0 GO:0000145 -0.016 0.079 0.152 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.077 -9999.0 0.0 -0.154 2.0 2.0 MLLT4 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.051 0.065 -9999.0 0.0 -0.259 1.0 1.0 ARF6 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.046 0.057 -9999.0 0.0 -0.165 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.066 0.165 1.0 -9999.0 0.0 1.0 PVRL2 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.084 0.163 2.0 -9999.0 0.0 2.0 ARF6/GTP 0.048 0.058 -9999.0 0.0 -0.156 1.0 1.0 CDH1 -0.024 0.101 -9999.0 0.0 -0.227 3.0 3.0 EGFR/EGFR/EGF/EGF -0.075 0.113 -9999.0 0.0 -0.279 3.0 3.0 RhoA/GDP -0.007 0.089 -9999.0 0.0 -0.172 3.0 3.0 actin cytoskeleton organization -0.02 0.079 0.148 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.012 0.051 -9999.0 0.0 -0.186 1.0 1.0 DIAPH1 0.021 0.095 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.0 0.075 0.153 2.0 -9999.0 0.0 2.0 RHOA 0.004 0.081 -9999.0 0.0 -0.309 1.0 1.0 RhoA/GTP -0.059 0.075 -9999.0 0.0 -0.234 2.0 2.0 CTNNA1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.021 0.08 0.15 2.0 -9999.0 0.0 2.0 EFNA1 0.003 0.081 -9999.0 0.0 -0.309 1.0 1.0 LPP -0.03 0.068 0.162 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 -0.01 0.091 -9999.0 0.0 -0.211 2.0 2.0 SEC6/SEC8 -0.037 0.05 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.019 0.083 0.163 2.0 -9999.0 0.0 2.0 HGF/MET -0.009 0.062 -9999.0 0.0 -9999.0 0.0 0.0 HGF 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.063 -9999.0 0.0 -0.175 2.0 2.0 actin cable formation 0.004 0.093 0.253 1.0 -9999.0 0.0 1.0 KIAA1543 -0.029 0.091 0.157 2.0 -9999.0 0.0 2.0 KIFC3 -0.036 0.075 0.155 1.0 -9999.0 0.0 1.0 NCK1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.028 0.07 0.171 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.075 -9999.0 0.0 -0.153 2.0 2.0 EXOC4 0.019 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.036 0.049 -9999.0 0.0 -0.146 2.0 2.0 PIP5K1C -0.017 0.084 0.163 2.0 -9999.0 0.0 2.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.036 0.097 0.172 1.0 -0.235 1.0 2.0 adherens junction assembly -0.038 0.145 0.254 1.0 -0.437 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.006 0.081 -9999.0 0.0 -0.182 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.016 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.011 0.082 0.163 2.0 -9999.0 0.0 2.0 mol:GTP 0.044 0.056 -9999.0 0.0 -0.164 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.002 0.091 0.136 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.017 0.062 -9999.0 0.0 -0.174 2.0 2.0 regulation of cell-cell adhesion -0.02 0.079 0.148 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.063 -9999.0 0.0 -0.175 2.0 2.0