IL12-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations IL12/IL12R/TYK2/JAK2/SOCS1 -0.112 0.146 -9999.0 0.0 -0.291 8.0 8.0 TBX21 -0.381 0.455 -9999.0 0.0 -0.998 8.0 8.0 B2M -0.017 0.131 -9999.0 0.0 -0.471 2.0 2.0 TYK2 0.006 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IL12RB1 0.006 0.018 -9999.0 0.0 -9999.0 0.0 0.0 GADD45B -0.461 0.526 -9999.0 0.0 -1.124 9.0 9.0 IL12RB2 -0.144 0.226 -9999.0 0.0 -0.455 9.0 9.0 GADD45G -0.296 0.342 -9999.0 0.0 -0.775 7.0 7.0 natural killer cell activation -0.009 0.018 -9999.0 0.0 -9999.0 0.0 0.0 RELB -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 RELA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18 -0.134 0.233 -9999.0 0.0 -0.483 8.0 8.0 IL2RA -0.012 0.103 -9999.0 0.0 -0.378 2.0 2.0 IFNG 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 STAT3 (dimer) -0.302 0.359 -9999.0 0.0 -0.791 8.0 8.0 HLA-DRB5 -0.132 0.249 -9999.0 0.0 -0.549 7.0 7.0 FASLG -0.388 0.45 -9999.0 0.0 -0.941 9.0 9.0 NF kappa B2 p52/RelB -0.395 0.446 -9999.0 0.0 -0.894 10.0 10.0 CD4 0.011 0.009 -9999.0 0.0 -9999.0 0.0 0.0 SOCS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:6955 -0.003 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CD3D 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CD3E 0.013 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CD3G 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IL12Rbeta2/JAK2 -0.101 0.167 -9999.0 0.0 -0.326 9.0 9.0 CCL3 -0.441 0.531 -9999.0 0.0 -1.122 8.0 8.0 CCL4 -0.492 0.608 -9999.0 0.0 -1.274 9.0 9.0 HLA-A -0.017 0.131 -9999.0 0.0 -0.471 2.0 2.0 IL18/IL18R -0.086 0.161 -9999.0 0.0 -0.372 4.0 4.0 NOS2 -0.338 0.386 -9999.0 0.0 -0.801 9.0 9.0 IL12/IL12R/TYK2/JAK2/SPHK2 -0.112 0.146 -9999.0 0.0 -0.3 6.0 6.0 IL1R1 -0.396 0.485 -9999.0 0.0 -1.048 8.0 8.0 IL4 0.026 0.017 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.006 0.018 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:6957 -0.003 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8 0.012 0.094 -9999.0 0.0 -0.4 1.0 1.0 RAB7A -0.287 0.323 -9999.0 0.0 -0.759 6.0 6.0 lysosomal transport -0.272 0.306 -9999.0 0.0 -0.716 6.0 6.0 FOS -0.461 0.589 -9999.0 0.0 -1.409 7.0 7.0 STAT4 (dimer) -0.362 0.406 -9999.0 0.0 -0.896 8.0 8.0 STAT5A (dimer) -0.394 0.435 -9999.0 0.0 -0.885 10.0 10.0 GZMA -0.38 0.448 -9999.0 0.0 -0.883 10.0 10.0 GZMB -0.408 0.484 -9999.0 0.0 -1.06 8.0 8.0 HLX 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LCK -0.411 0.501 -9999.0 0.0 -0.968 10.0 10.0 TCR/CD3/MHC II/CD4 -0.091 0.175 -9999.0 0.0 -0.349 7.0 7.0 IL2/IL2R 0.012 0.076 -9999.0 0.0 -9999.0 0.0 0.0 MAPK14 -0.359 0.406 -9999.0 0.0 -0.849 9.0 9.0 CCR5 -0.441 0.53 -9999.0 0.0 -1.014 10.0 10.0 IL1B -0.279 0.254 -9999.0 0.0 -0.479 16.0 16.0 STAT6 -0.152 0.269 -9999.0 0.0 -0.513 5.0 5.0 STAT4 -0.034 0.147 -9999.0 0.0 -0.441 3.0 3.0 STAT3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 NFKB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12B -0.012 0.113 -9999.0 0.0 -0.581 1.0 1.0 CD8A 0.002 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD8B 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 T-helper 1 cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 natural killer cell mediated cytotoxicity 0.111 0.145 0.289 8.0 -9999.0 0.0 8.0 IL2RB 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 proteasomal ubiquitin-dependent protein catabolic process -0.33 0.364 -9999.0 0.0 -0.805 8.0 8.0 IL2RG 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12 -0.102 0.182 -9999.0 0.0 -0.374 8.0 8.0 STAT5A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CD247 -0.016 0.102 -9999.0 0.0 -0.375 2.0 2.0 IL2 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 SPHK2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12A -0.126 0.231 -9999.0 0.0 -0.508 7.0 7.0 IL12/IL12R/TYK2/JAK2 -0.451 0.553 -9999.0 0.0 -1.056 10.0 10.0 MAP2K3 -0.362 0.405 -9999.0 0.0 -0.81 10.0 10.0 RIPK2 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 MAP2K6 -0.362 0.405 -9999.0 0.0 -0.81 10.0 10.0 regulation of dendritic cell antigen processing and presentation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HLA-DRA -0.076 0.189 -9999.0 0.0 -0.462 5.0 5.0 IL18RAP -0.031 0.123 -9999.0 0.0 -0.378 3.0 3.0 IL12Rbeta1/TYK2 0.008 0.029 -9999.0 0.0 -9999.0 0.0 0.0 EOMES 0.053 0.033 -9999.0 0.0 -9999.0 0.0 0.0 STAT1 (dimer) -0.304 0.344 -9999.0 0.0 -0.769 8.0 8.0 T cell proliferation -0.263 0.285 -9999.0 0.0 -0.626 8.0 8.0 T-helper 1 cell lineage commitment 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18R1 0.012 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CD8-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA -0.321 0.297 -9999.0 0.0 -0.647 10.0 10.0 ATF2 -0.324 0.369 -9999.0 0.0 -0.772 9.0 9.0