E-cadherin signaling in keratinocytes Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations keratinocyte differentiation -0.039 0.148 -9999.0 0.0 -0.675 1.0 1.0 adherens junction organization -0.097 0.191 -9999.0 0.0 -0.59 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.053 0.149 -9999.0 0.0 -0.616 1.0 1.0 FMN1 -0.095 0.189 -9999.0 0.0 -0.584 2.0 2.0 mol:IP3 -0.044 0.143 -9999.0 0.0 -0.654 1.0 1.0 E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.1 0.2 -9999.0 0.0 -0.617 2.0 2.0 CTNNB1 -0.023 0.154 -9999.0 0.0 -0.567 2.0 2.0 AKT1 -0.048 0.154 -9999.0 0.0 -0.684 1.0 1.0 E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.153 0.272 -9999.0 0.0 -0.479 9.0 9.0 CTNND1 0.016 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.085 0.184 -9999.0 0.0 -0.559 2.0 2.0 VASP -0.087 0.19 -9999.0 0.0 -0.577 2.0 2.0 ZYX -0.087 0.19 -9999.0 0.0 -0.577 2.0 2.0 JUB -0.105 0.192 -9999.0 0.0 -0.577 2.0 2.0 EGFR(dimer) -0.115 0.197 -9999.0 0.0 -0.517 3.0 3.0 E-cadherin/beta catenin-gamma catenin -0.147 0.195 -9999.0 0.0 -0.378 9.0 9.0 mol:PI-3-4-5-P3 -0.059 0.162 -9999.0 0.0 -0.734 1.0 1.0 PIK3CA 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.06 0.167 -9999.0 0.0 -0.759 1.0 1.0 FYN -0.027 0.136 -9999.0 0.0 -0.625 1.0 1.0 mol:Ca2+ -0.043 0.139 -9999.0 0.0 -0.633 1.0 1.0 JUP 0.021 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.006 0.113 -9999.0 0.0 -0.582 1.0 1.0 mol:DAG -0.044 0.143 -9999.0 0.0 -0.654 1.0 1.0 CDH1 -0.243 0.259 -9999.0 0.0 -0.484 14.0 14.0 RhoA/GDP -0.062 0.184 -9999.0 0.0 -0.851 1.0 1.0 establishment of polarity of embryonic epithelium -0.085 0.184 -9999.0 0.0 -0.559 2.0 2.0 SRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 EGFR -0.041 0.166 -9999.0 0.0 -0.503 3.0 3.0 CASR -0.04 0.132 -9999.0 0.0 -0.59 1.0 1.0 RhoA/GTP -0.041 0.168 -9999.0 0.0 -0.813 1.0 1.0 AKT2 -0.054 0.157 -9999.0 0.0 -0.684 1.0 1.0 actin cable formation -0.085 0.184 -9999.0 0.0 -0.56 2.0 2.0 apoptosis 0.05 0.151 0.677 1.0 -9999.0 0.0 1.0 CTNNA1 0.016 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.066 0.159 -9999.0 0.0 -0.677 1.0 1.0 PIP5K1A -0.087 0.19 -9999.0 0.0 -0.577 2.0 2.0 PLCG1 -0.046 0.147 -9999.0 0.0 -0.676 1.0 1.0 Rac1/GTP -0.1 0.18 -9999.0 0.0 -0.467 3.0 3.0 homophilic cell adhesion -0.001 0.004 -9999.0 0.0 -9999.0 0.0 0.0