Cellular roles of Anthrax toxin Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ANTXR1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ANTXR2 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 negative regulation of myeloid dendritic cell antigen processing and presentation -0.003 0.014 -9999.0 0.0 -0.074 1.0 1.0 monocyte activation -0.238 0.226 -9999.0 0.0 -0.423 14.0 14.0 MAP2K2 0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K7 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CYAA 0.005 0.059 -9999.0 0.0 -0.295 1.0 1.0 MAP2K4 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IL1B -0.13 0.132 -9999.0 0.0 -0.231 16.0 16.0 Channel 0.009 0.064 -9999.0 0.0 -0.315 1.0 1.0 NLRP1 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CALM1 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 negative regulation of phagocytosis -0.007 0.105 -9999.0 0.0 -0.533 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of endothelial cell proliferation 0.003 0.014 0.074 1.0 -9999.0 0.0 1.0 MAPK3 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PGR -0.013 0.058 -9999.0 0.0 -0.302 1.0 1.0 PA/Cellular Receptors 0.009 0.07 -9999.0 0.0 -0.346 1.0 1.0 apoptosis -0.003 0.014 -9999.0 0.0 -0.074 1.0 1.0 LOC728358 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Lethal toxin (unfolded) 0.009 0.06 -9999.0 0.0 -0.296 1.0 1.0 macrophage activation 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.1 0.201 -9999.0 0.0 -0.432 7.0 7.0 VCAM1 -0.24 0.228 -9999.0 0.0 -0.426 14.0 14.0 platelet activation -0.007 0.105 -9999.0 0.0 -0.533 1.0 1.0 MAPKKK cascade -0.015 0.014 -9999.0 0.0 -9999.0 0.0 0.0 IL18 -0.061 0.121 -9999.0 0.0 -0.241 8.0 8.0 negative regulation of macrophage activation -0.003 0.014 -9999.0 0.0 -0.074 1.0 1.0 LEF -0.003 0.014 -9999.0 0.0 -0.074 1.0 1.0 CASP1 -0.006 0.019 -9999.0 0.0 -0.082 1.0 1.0 mol:cAMP -0.023 0.102 -9999.0 0.0 -0.538 1.0 1.0 necrosis -0.003 0.014 -9999.0 0.0 -0.074 1.0 1.0 intracellular pH reduction -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAGA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Edema toxin (unfolded) 0.009 0.06 -9999.0 0.0 -0.296 1.0 1.0 mol:Epigallocatechin-3-gallate (EGCG) 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0