Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.102 0.171 -9999.0 0.0 -0.305 9.0 9.0 epithelial cell differentiation -0.122 0.174 -9999.0 0.0 -0.33 9.0 9.0 CYFIP2 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 ENAH -0.059 0.146 -9999.0 0.0 -0.412 2.0 2.0 EGFR -0.041 0.166 -9999.0 0.0 -0.503 3.0 3.0 EPHA2 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 MYO6 -0.119 0.199 -9999.0 0.0 -0.625 2.0 2.0 CTNNB1 -0.026 0.153 -9999.0 0.0 -0.566 2.0 2.0 ABI1/Sra1/Nap1 0.026 0.044 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.125 0.134 -9999.0 0.0 -0.454 2.0 2.0 CTNND1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.107 0.164 -9999.0 0.0 -0.478 2.0 2.0 regulation of calcium-dependent cell-cell adhesion -0.107 0.164 -9999.0 0.0 -0.478 2.0 2.0 EGF -0.012 0.103 -9999.0 0.0 -0.378 2.0 2.0 NCKAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.116 0.133 -9999.0 0.0 -0.454 2.0 2.0 cortical microtubule organization -0.122 0.174 -9999.0 0.0 -0.33 9.0 9.0 GO:0000145 -0.103 0.156 -9999.0 0.0 -0.455 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.121 0.177 -9999.0 0.0 -0.333 9.0 9.0 MLLT4 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 ARF6/GDP -0.109 0.135 -9999.0 0.0 -0.47 2.0 2.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.056 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.093 0.155 -9999.0 0.0 -0.445 2.0 2.0 PVRL2 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 ZYX -0.109 0.167 -9999.0 0.0 -0.487 2.0 2.0 ARF6/GTP 0.033 0.052 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.244 0.26 -9999.0 0.0 -0.486 14.0 14.0 EGFR/EGFR/EGF/EGF -0.158 0.153 -9999.0 0.0 -0.441 4.0 4.0 RhoA/GDP -0.138 0.181 -9999.0 0.0 -0.619 2.0 2.0 actin cytoskeleton organization -0.113 0.191 -9999.0 0.0 -0.482 3.0 3.0 IGF-1R heterotetramer 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 DIAPH1 0.002 0.046 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.122 0.174 0.33 9.0 -9999.0 0.0 9.0 RHOA -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 RhoA/GTP -0.118 0.166 -9999.0 0.0 -0.58 2.0 2.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.116 0.197 -9999.0 0.0 -0.498 3.0 3.0 EFNA1 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 LPP -0.103 0.157 -9999.0 0.0 -0.456 2.0 2.0 Ephrin A1/EPHA2 -0.133 0.158 -9999.0 0.0 -0.548 2.0 2.0 SEC6/SEC8 -0.127 0.166 -9999.0 0.0 -0.492 3.0 3.0 MGAT3 -0.109 0.167 -9999.0 0.0 -0.487 2.0 2.0 HGF/MET -0.144 0.149 -9999.0 0.0 -0.413 4.0 4.0 HGF -0.027 0.124 -9999.0 0.0 -0.378 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.102 0.172 -9999.0 0.0 -0.307 9.0 9.0 actin cable formation -0.037 0.128 -9999.0 0.0 -0.426 1.0 1.0 KIAA1543 -0.138 0.226 -9999.0 0.0 -0.572 4.0 4.0 KIFC3 -0.109 0.167 -9999.0 0.0 -0.487 2.0 2.0 NCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.116 0.164 -9999.0 0.0 -0.487 2.0 2.0 NCK1/GIT1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.122 0.174 -9999.0 0.0 -0.33 9.0 9.0 EXOC4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.109 0.167 -9999.0 0.0 -0.487 2.0 2.0 PIP5K1C -0.109 0.167 -9999.0 0.0 -0.487 2.0 2.0 LIMA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.069 0.162 -9999.0 0.0 -0.481 2.0 2.0 adherens junction assembly -0.113 0.219 -9999.0 0.0 -0.537 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.132 0.174 -9999.0 0.0 -0.599 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.007 0.113 -9999.0 0.0 -0.406 2.0 2.0 MET 0.002 0.075 -9999.0 0.0 -0.378 1.0 1.0 PLEKHA7 -0.109 0.167 -9999.0 0.0 -0.487 2.0 2.0 mol:GTP 0.026 0.055 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.086 0.183 -9999.0 0.0 -0.465 3.0 3.0 cortical actin cytoskeleton stabilization -0.102 0.171 -9999.0 0.0 -0.305 9.0 9.0 regulation of cell-cell adhesion -0.113 0.191 -9999.0 0.0 -0.482 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.102 0.172 -9999.0 0.0 -0.307 9.0 9.0