Signaling events regulated by Ret tyrosine kinase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PTK2 -0.053 0.147 -9999.0 0.0 -0.781 1.0 1.0 Crk/p130 Cas/Paxillin -0.065 0.103 -9999.0 0.0 -0.341 2.0 2.0 JUN -0.077 0.142 -9999.0 0.0 -0.369 2.0 2.0 HRAS 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/GRB10 -0.134 0.182 -9999.0 0.0 -0.369 8.0 8.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FRS2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A/GDP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/DOK1 -0.111 0.184 -9999.0 0.0 -0.369 7.0 7.0 EntrezGene:5979 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Enigma 0.007 0.089 -9999.0 0.0 -0.306 2.0 2.0 RHOA -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 RAP1A/GTP -0.096 0.122 -9999.0 0.0 -0.289 6.0 6.0 GRB7 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 MAPKKK cascade -0.099 0.135 -9999.0 0.0 -0.45 2.0 2.0 BCAR1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/IRS1 0.007 0.089 -9999.0 0.0 -0.306 2.0 2.0 lamellipodium assembly -0.06 0.096 -9999.0 0.0 -0.29 3.0 3.0 RET51/GFRalpha1/GDNF/SHC -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/SHC 0.007 0.089 -9999.0 0.0 -0.306 2.0 2.0 RET9/GFRalpha1/GDNF/Shank3 0.007 0.089 -9999.0 0.0 -0.306 2.0 2.0 MAPK3 -0.061 0.135 -9999.0 0.0 -0.406 1.0 1.0 DOK1 -0.026 0.153 -9999.0 0.0 -0.566 2.0 2.0 DOK6 -0.106 0.232 -9999.0 0.0 -0.535 6.0 6.0 PXN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neurite development -0.07 0.14 -9999.0 0.0 -0.36 2.0 2.0 DOK5 -0.07 0.207 -9999.0 0.0 -0.566 4.0 4.0 GFRA1 -0.026 0.153 -9999.0 0.0 -0.566 2.0 2.0 MAPK8 -0.059 0.139 -9999.0 0.0 -0.395 2.0 2.0 HRAS/GTP -0.118 0.157 -9999.0 0.0 -0.349 7.0 7.0 tube development 0.015 0.084 -9999.0 0.0 -0.28 2.0 2.0 MAPK1 -0.061 0.135 -9999.0 0.0 -0.406 1.0 1.0 RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 0.016 0.073 -9999.0 0.0 -0.242 2.0 2.0 Rac1/GDP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDLIM7 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok6 -0.138 0.194 -9999.0 0.0 -0.356 10.0 10.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/Dok4 -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 RET51/GFRalpha1/GDNF/Dok5 -0.135 0.203 -9999.0 0.0 -0.398 8.0 8.0 PRKCA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GDP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREB1 -0.018 0.1 -9999.0 0.0 -0.316 2.0 2.0 PIK3R1 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 0.016 0.073 -9999.0 0.0 -0.242 2.0 2.0 RET51/GFRalpha1/GDNF/Grb7 -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET -0.172 0.235 -9999.0 0.0 -0.447 11.0 11.0 DOK4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade -0.076 0.14 -9999.0 0.0 -0.362 2.0 2.0 RET9/GFRalpha1/GDNF/FRS2 0.007 0.089 -9999.0 0.0 -0.306 2.0 2.0 SHANK3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RASA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 0.016 0.074 -9999.0 0.0 -0.244 2.0 2.0 RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.052 0.123 -9999.0 0.0 -0.357 1.0 1.0 RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.072 0.147 -9999.0 0.0 -0.426 2.0 2.0 RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.053 0.127 -9999.0 0.0 -0.401 1.0 1.0 PI3K -0.047 0.171 -9999.0 0.0 -0.435 3.0 3.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET9/GFRalpha1/GDNF/Shank3/Grb2 0.016 0.084 -9999.0 0.0 -0.28 2.0 2.0 GRB10 -0.07 0.187 -9999.0 0.0 -0.453 5.0 5.0 activation of MAPKK activity -0.032 0.099 -9999.0 0.0 -0.321 1.0 1.0 RET51/GFRalpha1/GDNF/FRS2 -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 GAB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IRS2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.053 0.127 -9999.0 0.0 -0.401 1.0 1.0 RET51/GFRalpha1/GDNF/PKC alpha -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKACA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GDNF 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RET51/GFRalpha1/GDNF/IRS1 -0.087 0.159 -9999.0 0.0 -0.329 6.0 6.0 Rac1/GTP -0.07 0.113 -9999.0 0.0 -0.344 3.0 3.0 RET9/GFRalpha1/GDNF -0.004 0.097 -9999.0 0.0 -0.346 2.0 2.0 GFRalpha1/GDNF -0.007 0.113 -9999.0 0.0 -0.406 2.0 2.0