Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.014 0.139 -9999.0 0.0 -0.37 1.0 1.0 CRKL -0.023 0.146 -9999.0 0.0 -0.359 2.0 2.0 HRAS -0.021 0.14 -9999.0 0.0 -9999.0 0.0 0.0 mol:PIP3 -0.048 0.147 -9999.0 0.0 -0.319 4.0 4.0 SPRED1 -0.034 0.147 -9999.0 0.0 -0.441 3.0 3.0 SPRED2 -0.026 0.153 -9999.0 0.0 -0.566 2.0 2.0 GAB1 -0.032 0.153 -9999.0 0.0 -0.384 2.0 2.0 FOXO3 -0.044 0.147 -9999.0 0.0 -0.321 3.0 3.0 AKT1 -0.055 0.156 -9999.0 0.0 -0.339 4.0 4.0 BAD -0.044 0.147 -9999.0 0.0 -0.311 4.0 4.0 megakaryocyte differentiation -0.084 0.209 -9999.0 0.0 -0.417 6.0 6.0 GSK3B -0.044 0.147 -9999.0 0.0 -0.321 3.0 3.0 RAF1 -0.008 0.12 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.032 0.153 -9999.0 0.0 -0.384 2.0 2.0 STAT1 -0.085 0.314 -9999.0 0.0 -1.011 2.0 2.0 HRAS/SPRED1 -0.029 0.134 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation -0.031 0.151 -9999.0 0.0 -0.377 2.0 2.0 PIK3CA 0.017 0.001 -9999.0 0.0 -9999.0 0.0 0.0 TEC 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.042 0.155 -9999.0 0.0 -0.347 3.0 3.0 HRAS/SPRED2 -0.026 0.137 -9999.0 0.0 -0.378 1.0 1.0 LYN/TEC/p62DOK -0.035 0.169 -9999.0 0.0 -0.394 3.0 3.0 MAPK3 0.008 0.093 -9999.0 0.0 -9999.0 0.0 0.0 STAP1 -0.039 0.169 -9999.0 0.0 -0.47 2.0 2.0 GRAP2 -0.005 0.11 -9999.0 0.0 -0.566 1.0 1.0 JAK2 -0.066 0.255 -9999.0 0.0 -0.761 2.0 2.0 STAT1 (dimer) -0.082 0.308 -9999.0 0.0 -0.986 2.0 2.0 mol:Gleevec 0.0 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 -0.055 0.168 -9999.0 0.0 -0.448 3.0 3.0 actin filament polymerization -0.039 0.15 -9999.0 0.0 -0.337 3.0 3.0 LYN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAP1/STAT5A (dimer) -0.04 0.209 -9999.0 0.0 -0.606 2.0 2.0 PIK3R1 -0.005 0.11 -9999.0 0.0 -0.567 1.0 1.0 CBL/CRKL/GRB2 -0.005 0.136 -9999.0 0.0 -0.353 1.0 1.0 PI3K -0.035 0.17 -9999.0 0.0 -0.395 3.0 3.0 PTEN 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT/EPO/EPOR -0.112 0.349 -9999.0 0.0 -1.208 2.0 2.0 MAPK8 -0.032 0.153 -9999.0 0.0 -0.384 2.0 2.0 STAT3 (dimer) -0.031 0.151 -9999.0 0.0 -0.377 2.0 2.0 positive regulation of transcription 0.011 0.081 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.033 0.149 -9999.0 0.0 -0.364 3.0 3.0 PIK3C2B -0.039 0.162 -9999.0 0.0 -0.366 3.0 3.0 CBL/CRKL -0.013 0.139 -9999.0 0.0 -0.37 1.0 1.0 FER -0.032 0.153 -9999.0 0.0 -0.384 2.0 2.0 SH2B3 -0.032 0.153 -9999.0 0.0 -0.384 2.0 2.0 PDPK1 -0.038 0.139 -9999.0 0.0 -0.311 3.0 3.0 SNAI2 -0.052 0.179 -9999.0 0.0 -0.422 3.0 3.0 positive regulation of cell proliferation -0.054 0.232 -9999.0 0.0 -0.676 2.0 2.0 KITLG -0.041 0.168 -9999.0 0.0 -0.506 3.0 3.0 cell motility -0.054 0.232 -9999.0 0.0 -0.676 2.0 2.0 PTPN6 -0.047 0.159 -9999.0 0.0 -0.422 4.0 4.0 EPOR 0.007 0.105 -9999.0 0.0 -9999.0 0.0 0.0 STAT5A (dimer) -0.041 0.198 -9999.0 0.0 -0.541 2.0 2.0 SOCS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell migration 0.076 0.191 0.441 4.0 -9999.0 0.0 4.0 SOS1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EPO 0.015 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.07 0.187 -9999.0 0.0 -0.453 5.0 5.0 GRB10 -0.075 0.174 -9999.0 0.0 -0.392 4.0 4.0 PTPN11 0.017 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT -0.041 0.162 -9999.0 0.0 -0.41 2.0 2.0 GO:0007205 0.002 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 0.003 0.101 -9999.0 0.0 -9999.0 0.0 0.0 CBL 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KIT -0.095 0.362 -9999.0 0.0 -1.296 2.0 2.0 MAP2K2 0.003 0.101 -9999.0 0.0 -9999.0 0.0 0.0 SHC/Grb2/SOS1 -0.014 0.145 -9999.0 0.0 -0.349 2.0 2.0 STAT5A -0.043 0.202 -9999.0 0.0 -0.557 2.0 2.0 GRB2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.05 0.176 -9999.0 0.0 -0.414 3.0 3.0 SHC/GRAP2 0.009 0.081 -9999.0 0.0 -0.406 1.0 1.0 PTPRO -0.086 0.212 -9999.0 0.0 -0.425 6.0 6.0 SH2B2 -0.04 0.153 -9999.0 0.0 -0.344 3.0 3.0 DOK1 -0.026 0.153 -9999.0 0.0 -0.566 2.0 2.0 MATK -0.078 0.194 -9999.0 0.0 -0.45 4.0 4.0 CREBBP 0.034 0.021 -9999.0 0.0 -9999.0 0.0 0.0 BCL2 -0.039 0.266 -9999.0 0.0 -1.277 1.0 1.0