Regulation of cytoplasmic and nuclear SMAD2/3 signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SMAD4 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SMAD2 0.036 0.057 -9999.0 0.0 -9999.0 0.0 0.0 SMAD3 0.06 0.052 -9999.0 0.0 -9999.0 0.0 0.0 SMAD3/SMAD4 0.061 0.033 -9999.0 0.0 -9999.0 0.0 0.0 SMAD4/Ubc9/PIASy 0.061 0.026 -9999.0 0.0 -9999.0 0.0 0.0 SMAD2/SMAD2/SMAD4 0.088 0.058 -9999.0 0.0 -9999.0 0.0 0.0 PPM1A 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CALM1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SMAD2/SMAD4 0.051 0.054 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 0.028 0.034 -9999.0 0.0 -0.141 1.0 1.0 TRAP-1/SMAD4 0.051 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NUP214 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP2 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTDSPL 0.02 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KPNB1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TGFBRAP1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 UBE2I 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NUP153 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 KPNA2 0.022 0.046 -9999.0 0.0 -0.141 2.0 2.0 PIAS4 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0