Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) 0.061 0.022 -9999.0 0.0 -9999.0 0.0 0.0 HDAC1 0.027 0.02 -9999.0 0.0 -9999.0 0.0 0.0 AES 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LRP6/FZD1 0.041 0.022 -9999.0 0.0 -9999.0 0.0 0.0 TLE1 0.012 0.089 -9999.0 0.0 -0.274 2.0 2.0 AP1 -0.081 0.122 -9999.0 0.0 -0.269 7.0 7.0 NCSTN 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADAM10 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.022 0.059 -9999.0 0.0 -9999.0 0.0 0.0 NICD/RBPSUH 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 WIF1 -0.173 0.19 -9999.0 0.0 -0.296 17.0 17.0 NOTCH1 0.037 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PSENEN 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 KREMEN2 -0.007 0.1 -9999.0 0.0 -0.193 5.0 5.0 DKK1 -0.047 0.143 -9999.0 0.0 -0.24 8.0 8.0 beta catenin/beta TrCP1 -0.014 0.113 -9999.0 0.0 -0.309 2.0 2.0 APH1B 0.029 0.033 -9999.0 0.0 -0.141 1.0 1.0 APH1A 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AXIN1 0.02 0.038 -9999.0 0.0 -9999.0 0.0 0.0 CtBP/CBP/TCF1/TLE1/AES 0.007 0.08 -9999.0 0.0 -0.373 1.0 1.0 PSEN1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.105 0.187 -9999.0 0.0 -0.308 11.0 11.0 JUN 0.02 0.035 -9999.0 0.0 -0.141 1.0 1.0 MAP3K7 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 -0.029 0.108 -9999.0 0.0 -0.323 2.0 2.0 MAPK3 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 0.031 0.075 -9999.0 0.0 -0.24 1.0 1.0 HNF1A -0.001 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTBP1 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MYC -0.02 0.272 -9999.0 0.0 -1.393 1.0 1.0 NKD1 0.016 0.055 -9999.0 0.0 -0.141 3.0 3.0 FZD1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH1 precursor/Deltex homolog 1 0.062 0.016 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.08 0.122 -9999.0 0.0 -0.267 7.0 7.0 Delta 1/NOTCHprecursor 0.057 0.023 -9999.0 0.0 -9999.0 0.0 0.0 DLL1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PPARD 0.034 0.031 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.081 0.047 -9999.0 0.0 -9999.0 0.0 0.0 APC 0.02 0.038 -9999.0 0.0 -9999.0 0.0 0.0 DVL1 -0.035 0.114 -9999.0 0.0 -0.242 6.0 6.0 CSNK2A1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DKK1/LRP6/Kremen 2 -0.03 0.115 -9999.0 0.0 -0.255 4.0 4.0 LRP6 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CSNK1A1 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NLK 0.028 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 -0.029 0.273 -9999.0 0.0 -1.403 1.0 1.0 WNT1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/beta catenin -0.005 0.1 -9999.0 0.0 -9999.0 0.0 0.0 DKK2 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH1 precursor/DVL1 -0.0 0.101 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH/Deltex homolog 1 0.065 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PPP2R5D 0.005 0.055 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WNT1/LRP6/FZD1 -0.064 0.122 -9999.0 0.0 -0.217 9.0 9.0 RBPJ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0