Canonical NF-kappaB pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations FBXW11 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA/I kappa B alpha 0.069 0.054 -9999.0 0.0 -9999.0 0.0 0.0 ERC1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RIP2/NOD2 0.021 0.022 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIA 0.029 0.037 0.218 1.0 -9999.0 0.0 1.0 BIRC2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IKBKB 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RIPK2 0.028 0.034 -9999.0 0.0 -0.141 1.0 1.0 IKBKG 0.033 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex/A20 0.051 0.077 -9999.0 0.0 -9999.0 0.0 0.0 NEMO/A20/RIP2 0.028 0.034 -9999.0 0.0 -0.14 1.0 1.0 XPO1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NEMO/ATM 0.052 0.03 -9999.0 0.0 -9999.0 0.0 0.0 tumor necrosis factor receptor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAN 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Exportin 1/RanGTP 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IKK complex/ELKS 0.055 0.03 -9999.0 0.0 -9999.0 0.0 0.0 BCL10/MALT1/TRAF6 0.056 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NOD2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MALT1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 cIAP1/UbcH5C 0.047 0.017 -9999.0 0.0 -9999.0 0.0 0.0 ATM 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TNF/TNFR1A -0.003 0.094 -9999.0 0.0 -0.285 2.0 2.0 TRAF6 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CHUK 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 UBE2D3 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.03 0.126 -9999.0 0.0 -0.216 7.0 7.0 NF kappa B1 p50/RelA 0.076 0.021 -9999.0 0.0 -9999.0 0.0 0.0 BCL10 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 proteasomal ubiquitin-dependent protein catabolic process 0.029 0.037 0.218 1.0 -9999.0 0.0 1.0 beta TrCP1/SCF ubiquitin ligase complex 0.038 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFRSF1A 0.013 0.083 -9999.0 0.0 -0.404 1.0 1.0 IKK complex 0.073 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CYLD 0.028 0.034 -9999.0 0.0 -0.141 1.0 1.0 IKK complex/PKC alpha 0.087 0.039 -9999.0 0.0 -9999.0 0.0 0.0