E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.13 0.217 -9999.0 0.0 -0.448 8.0 8.0 KLHL20 -0.024 0.106 0.225 1.0 -0.233 1.0 2.0 CYFIP2 0.028 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.068 0.14 -9999.0 0.0 -0.26 9.0 9.0 ENAH -0.129 0.216 -9999.0 0.0 -0.427 9.0 9.0 AP1M1 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.003 0.115 -9999.0 0.0 -0.404 2.0 2.0 CDC42/GTP -0.047 0.106 -9999.0 0.0 -0.253 2.0 2.0 ABI1/Sra1/Nap1 -0.036 0.044 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.051 0.154 -9999.0 0.0 -0.246 9.0 9.0 RAPGEF1 -0.112 0.201 -9999.0 0.0 -0.39 9.0 9.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.136 0.231 -9999.0 0.0 -0.456 9.0 9.0 CRK -0.12 0.218 -9999.0 0.0 -0.419 9.0 9.0 E-cadherin/gamma catenin/alpha catenin -0.053 0.134 -9999.0 0.0 -0.24 8.0 8.0 alphaE/beta7 Integrin 0.053 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.035 0.059 -9999.0 0.0 -0.216 1.0 1.0 DLG1 -0.129 0.212 -9999.0 0.0 -0.427 9.0 9.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.048 0.065 -9999.0 0.0 -0.154 2.0 2.0 MLLT4 0.017 0.083 -9999.0 0.0 -0.404 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.055 0.055 -9999.0 0.0 -0.216 1.0 1.0 PI3K -0.058 0.084 -9999.0 0.0 -0.195 2.0 2.0 ARF6 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.079 0.145 -9999.0 0.0 -0.285 8.0 8.0 TIAM1 0.019 0.083 -9999.0 0.0 -0.404 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.051 0.142 -9999.0 0.0 -0.231 9.0 9.0 AKT1 -0.032 0.054 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.019 0.083 -9999.0 0.0 -0.404 1.0 1.0 CDH1 -0.134 0.188 -9999.0 0.0 -0.404 8.0 8.0 RhoA/GDP -0.062 0.148 -9999.0 0.0 -0.261 9.0 9.0 actin cytoskeleton organization -0.016 0.082 0.188 1.0 -0.169 1.0 2.0 CDC42/GDP -0.069 0.138 -9999.0 0.0 -0.266 6.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.052 0.102 -9999.0 0.0 -0.206 8.0 8.0 ITGB7 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.054 0.152 -9999.0 0.0 -0.246 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.058 0.134 -9999.0 0.0 -0.23 9.0 9.0 mol:GDP -0.085 0.158 -9999.0 0.0 -0.298 9.0 9.0 CDC42/GTP/IQGAP1 0.035 0.021 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.059 0.154 -9999.0 0.0 -0.267 9.0 9.0 RAC1/GTP/IQGAP1 0.044 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.045 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.064 0.143 1.0 -0.174 1.0 2.0 NME1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.136 0.223 -9999.0 0.0 -0.444 9.0 9.0 regulation of cell-cell adhesion -0.05 0.086 -9999.0 0.0 -0.223 2.0 2.0 WASF2 -0.001 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.057 0.119 -9999.0 0.0 -0.283 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.006 0.138 -9999.0 0.0 -0.205 8.0 8.0 CCND1 -0.012 0.076 0.163 1.0 -0.215 1.0 2.0 VAV2 -0.098 0.218 -9999.0 0.0 -0.575 1.0 1.0 RAP1/GDP -0.054 0.128 -9999.0 0.0 -0.285 2.0 2.0 adherens junction assembly -0.131 0.216 -9999.0 0.0 -0.43 9.0 9.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.046 0.141 -9999.0 0.0 -0.223 9.0 9.0 E-cadherin/beta catenin -0.075 0.141 -9999.0 0.0 -0.31 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.135 0.223 -9999.0 0.0 -0.444 9.0 9.0 PIK3CA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.084 0.11 -9999.0 0.0 -0.377 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.07 0.157 -9999.0 0.0 -0.27 9.0 9.0 ITGAE 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.139 0.236 -9999.0 0.0 -0.466 9.0 9.0