amb2 Integrin signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations alphaM/beta2 Integrin/proMMP-2 0.011 0.128 -9999.0 0.0 -0.375 2.0 2.0 alphaM/beta2 Integrin/GPIbA 0.011 0.128 -9999.0 0.0 -0.375 2.0 2.0 alphaM/beta2 Integrin/proMMP-9 -0.035 0.149 -9999.0 0.0 -0.307 5.0 5.0 PLAUR 0.026 0.016 -9999.0 0.0 -9999.0 0.0 0.0 HMGB1 0.028 0.021 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/Talin 0.011 0.128 -9999.0 0.0 -0.375 2.0 2.0 AGER 0.029 0.02 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SELPLG -0.008 0.099 -9999.0 0.0 -0.193 5.0 5.0 mol:LDL -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/RAGE/HMGB1 0.024 0.15 -9999.0 0.0 -0.33 3.0 3.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MMP9 -0.028 0.141 -9999.0 0.0 -0.299 5.0 5.0 CYR61 -0.018 0.119 -9999.0 0.0 -0.272 4.0 4.0 TLN1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.032 0.086 -9999.0 0.0 -0.293 1.0 1.0 RHOA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 P-selectin oligomer 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYH2 0.043 0.06 0.223 1.0 -9999.0 0.0 1.0 MST1R 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 leukocyte activation during inflammatory response 0.01 0.089 -9999.0 0.0 -0.238 2.0 2.0 APOB 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 complement component iC3b receptor activity -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MMP2 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JAM3 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GP1BA 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/CTGF -0.009 0.127 -9999.0 0.0 -0.375 2.0 2.0 alphaM/beta2 Integrin 0.027 0.049 -9999.0 0.0 -9999.0 0.0 0.0 JAM3 homodimer 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ICAM2 0.019 0.083 -9999.0 0.0 -0.404 1.0 1.0 ICAM1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 phagocytosis triggered by activation of immune response cell surface activating receptor 0.027 0.049 -9999.0 0.0 -9999.0 0.0 0.0 cell adhesion 0.01 0.127 -9999.0 0.0 -0.374 2.0 2.0 NFKB1 -0.053 0.155 -9999.0 0.0 -0.513 2.0 2.0 THY1 0.011 0.088 -9999.0 0.0 -0.272 2.0 2.0 RhoA/GDP 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Lipoprotein(a) 0.035 0.021 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/LRP/tPA -0.0 0.141 -9999.0 0.0 -0.324 3.0 3.0 IL6 -0.063 0.142 -9999.0 0.0 -0.469 2.0 2.0 ITGB2 -0.03 0.126 -9999.0 0.0 -0.329 3.0 3.0 elevation of cytosolic calcium ion concentration 0.006 0.121 -9999.0 0.0 -0.33 2.0 2.0 alphaM/beta2 Integrin/JAM2/JAM3 0.025 0.126 -9999.0 0.0 -0.345 2.0 2.0 JAM2 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/ICAM1 0.062 0.088 -9999.0 0.0 -0.224 2.0 2.0 alphaM/beta2 Integrin/uPA/Plg 0.016 0.127 -9999.0 0.0 -0.345 2.0 2.0 RhoA/GTP 0.04 0.05 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of phagocytosis -0.0 0.131 -9999.0 0.0 -0.58 1.0 1.0 Ron/MSP 0.043 0.03 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/uPAR/uPA 0.007 0.123 -9999.0 0.0 -0.332 2.0 2.0 alphaM/beta2 Integrin/uPAR -0.004 0.122 -9999.0 0.0 -0.362 2.0 2.0 PLAU 0.028 0.034 -9999.0 0.0 -0.141 1.0 1.0 PLAT -0.0 0.097 -9999.0 0.0 -0.207 4.0 4.0 actin filament polymerization 0.033 0.08 0.221 1.0 -0.247 1.0 2.0 MST1 0.026 0.034 -9999.0 0.0 -0.141 1.0 1.0 alphaM/beta2 Integrin/lipoprotein(a) 0.014 0.092 -9999.0 0.0 -0.24 2.0 2.0 TNF -0.087 0.221 -9999.0 0.0 -0.82 2.0 2.0 RAP1B 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/uPA 0.005 0.13 -9999.0 0.0 -0.302 3.0 3.0 fibrinolysis 0.014 0.125 -9999.0 0.0 -0.343 2.0 2.0 HCK 0.005 0.093 -9999.0 0.0 -0.229 3.0 3.0 dendritic cell antigen processing and presentation 0.027 0.049 -9999.0 0.0 -9999.0 0.0 0.0 VTN 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/CYR61 -0.036 0.137 -9999.0 0.0 -0.309 4.0 4.0 LPA 0.026 0.016 -9999.0 0.0 -9999.0 0.0 0.0 LRP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 cell migration -0.034 0.135 -9999.0 0.0 -0.28 5.0 5.0 FN1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 alphaM/beta2 Integrin/Thy1 -0.01 0.135 -9999.0 0.0 -0.328 3.0 3.0 MPO 0.006 0.093 -9999.0 0.0 -0.229 3.0 3.0 KNG1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1/GDP 0.035 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.048 0.049 0.223 1.0 -9999.0 0.0 1.0 ELA2 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PLG 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTGF 0.015 0.055 -9999.0 0.0 -0.141 3.0 3.0 alphaM/beta2 Integrin/Hck -0.005 0.162 -9999.0 0.0 -0.473 2.0 2.0 ITGAM 0.012 0.09 -9999.0 0.0 -0.434 1.0 1.0 alphaM/beta2 Integrin/P-Selectin/PSGL1 -0.003 0.136 -9999.0 0.0 -0.301 3.0 3.0 HP 0.029 0.033 -9999.0 0.0 -0.141 1.0 1.0 leukocyte adhesion 0.002 0.144 -9999.0 0.0 -0.571 1.0 1.0 SELP 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0