Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.085 0.198 -9999.0 0.0 -0.528 4.0 4.0 IHH -0.002 0.058 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.051 0.118 -9999.0 0.0 -0.249 6.0 6.0 LRPAP1 0.029 0.033 -9999.0 0.0 -0.141 1.0 1.0 dorsoventral neural tube patterning 0.051 0.117 0.247 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.009 0.16 -9999.0 0.0 -0.568 1.0 1.0 SMO -0.045 0.146 -9999.0 0.0 -0.393 3.0 3.0 AKT1 0.006 0.073 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.005 0.118 -9999.0 0.0 -0.316 3.0 3.0 ADRBK1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.044 0.144 -9999.0 0.0 -0.387 3.0 3.0 STIL -0.044 0.128 0.192 1.0 -0.257 5.0 6.0 DHH N/PTCH2 0.045 0.019 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.032 0.108 -9999.0 0.0 -0.263 4.0 4.0 PIK3CA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.116 0.3 -9999.0 0.0 -0.792 4.0 4.0 determination of left/right symmetry -0.044 0.144 -9999.0 0.0 -0.387 3.0 3.0 PIK3R1 0.019 0.083 -9999.0 0.0 -0.404 1.0 1.0 skeletal system development -0.114 0.297 -9999.0 0.0 -0.782 4.0 4.0 IHH N/Hhip -0.069 0.147 -9999.0 0.0 -0.321 6.0 6.0 DHH N/Hhip -0.048 0.136 -9999.0 0.0 -0.285 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.044 0.144 -9999.0 0.0 -0.387 3.0 3.0 pancreas development -0.091 0.178 -9999.0 0.0 -0.298 10.0 10.0 HHAT -0.021 0.14 -9999.0 0.0 -0.338 4.0 4.0 PI3K 0.049 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.069 0.157 -9999.0 0.0 -0.246 10.0 10.0 somite specification -0.044 0.144 -9999.0 0.0 -0.387 3.0 3.0 SHH Np/Cholesterol/PTCH1 -0.056 0.104 -9999.0 0.0 -0.218 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.002 0.077 -9999.0 0.0 -0.207 3.0 3.0 SHH Np/Cholesterol/Megalin -0.026 0.119 -9999.0 0.0 -0.294 4.0 4.0 SHH -0.021 0.096 -9999.0 0.0 -0.285 3.0 3.0 catabolic process -0.05 0.112 -9999.0 0.0 -0.298 4.0 4.0 SMO/Vitamin D3 -0.051 0.129 0.195 1.0 -0.281 5.0 6.0 SHH Np/Cholesterol/Hhip -0.063 0.136 -9999.0 0.0 -0.273 7.0 7.0 LRP2 -0.025 0.124 -9999.0 0.0 -0.229 6.0 6.0 receptor-mediated endocytosis -0.066 0.138 -9999.0 0.0 -0.28 6.0 6.0 SHH Np/Cholesterol/BOC -0.024 0.096 -9999.0 0.0 -0.216 5.0 5.0 SHH Np/Cholesterol/CDO 0.008 0.067 -9999.0 0.0 -0.216 2.0 2.0 mesenchymal cell differentiation 0.062 0.135 0.271 7.0 -9999.0 0.0 7.0 mol:Vitamin D3 -0.033 0.129 0.197 2.0 -0.234 5.0 7.0 IHH N/PTCH2 0.034 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.018 0.083 -9999.0 0.0 -0.404 1.0 1.0 IHH N/PTCH1 -0.04 0.12 -9999.0 0.0 -0.299 4.0 4.0 Megalin/LRPAP1 0.002 0.105 -9999.0 0.0 -0.32 2.0 2.0 PTCH2 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.005 0.08 0.15 1.0 -0.215 3.0 4.0 PTCH1 -0.05 0.112 -9999.0 0.0 -0.298 4.0 4.0 HHIP -0.091 0.178 -9999.0 0.0 -0.299 10.0 10.0