Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.072 0.135 -9999.0 0.0 -0.244 9.0 9.0 epithelial cell differentiation -0.054 0.138 -9999.0 0.0 -0.229 9.0 9.0 CYFIP2 0.028 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.056 0.073 -9999.0 0.0 -0.298 1.0 1.0 EGFR -0.006 0.118 -9999.0 0.0 -0.316 3.0 3.0 EPHA2 0.021 0.035 -9999.0 0.0 -0.141 1.0 1.0 MYO6 -0.075 0.141 0.185 1.0 -0.24 9.0 10.0 CTNNB1 0.003 0.115 -9999.0 0.0 -0.404 2.0 2.0 ABI1/Sra1/Nap1 0.056 0.036 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.06 0.111 -9999.0 0.0 -0.379 1.0 1.0 CTNND1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.057 0.109 0.183 1.0 -0.199 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.068 0.119 0.183 1.0 -0.217 9.0 10.0 EGF 0.021 0.046 -9999.0 0.0 -0.141 2.0 2.0 NCKAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.059 0.112 -9999.0 0.0 -0.379 1.0 1.0 cortical microtubule organization -0.054 0.138 -9999.0 0.0 -0.229 9.0 9.0 GO:0000145 -0.066 0.096 0.168 1.0 -0.19 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.051 0.142 -9999.0 0.0 -0.231 9.0 9.0 MLLT4 0.017 0.083 -9999.0 0.0 -0.404 1.0 1.0 ARF6/GDP -0.081 0.092 -9999.0 0.0 -0.301 2.0 2.0 ARF6 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.056 0.053 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.076 0.118 -9999.0 0.0 -0.283 5.0 5.0 PVRL2 0.01 0.083 -9999.0 0.0 -0.404 1.0 1.0 ZYX -0.062 0.123 0.185 1.0 -0.22 9.0 10.0 ARF6/GTP 0.072 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.134 0.188 -9999.0 0.0 -0.404 8.0 8.0 EGFR/EGFR/EGF/EGF -0.077 0.13 -9999.0 0.0 -0.22 11.0 11.0 RhoA/GDP -0.048 0.136 -9999.0 0.0 -0.22 9.0 9.0 actin cytoskeleton organization -0.077 0.135 0.172 1.0 -0.236 9.0 10.0 IGF-1R heterotetramer 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.019 0.083 -9999.0 0.0 -0.404 1.0 1.0 DIAPH1 0.026 0.146 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.054 0.138 0.229 9.0 -9999.0 0.0 9.0 RHOA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.082 0.094 -9999.0 0.0 -0.309 2.0 2.0 CTNNA1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.079 0.138 0.174 1.0 -0.242 9.0 10.0 EFNA1 0.029 0.033 -9999.0 0.0 -0.141 1.0 1.0 LPP -0.065 0.101 0.176 1.0 -0.193 9.0 10.0 Ephrin A1/EPHA2 -0.061 0.126 -9999.0 0.0 -0.236 6.0 6.0 SEC6/SEC8 -0.075 0.126 -9999.0 0.0 -0.243 7.0 7.0 MGAT3 -0.069 0.121 0.185 1.0 -0.22 9.0 10.0 HGF/MET -0.058 0.129 -9999.0 0.0 -0.22 9.0 9.0 HGF 0.012 0.055 -9999.0 0.0 -0.141 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.072 0.136 -9999.0 0.0 -0.246 9.0 9.0 actin cable formation -0.037 0.079 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.081 0.114 -9999.0 0.0 -0.217 10.0 10.0 KIFC3 -0.069 0.121 0.185 1.0 -0.22 9.0 10.0 NCK1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.072 0.12 0.185 1.0 -0.22 9.0 10.0 NCK1/GIT1 0.051 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.054 0.138 -9999.0 0.0 -0.229 9.0 9.0 EXOC4 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.086 0.102 -9999.0 0.0 -0.219 9.0 9.0 PIP5K1C -0.058 0.11 0.185 1.0 -0.202 9.0 10.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.066 0.092 -9999.0 0.0 -0.349 1.0 1.0 adherens junction assembly -0.042 0.138 0.299 1.0 -0.416 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.058 0.148 -9999.0 0.0 -0.234 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.01 0.087 -9999.0 0.0 -0.285 2.0 2.0 MET 0.025 0.034 -9999.0 0.0 -0.141 1.0 1.0 PLEKHA7 -0.075 0.112 -9999.0 0.0 -0.22 9.0 9.0 mol:GTP 0.054 0.051 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.062 0.14 0.262 1.0 -0.312 3.0 4.0 cortical actin cytoskeleton stabilization -0.072 0.135 -9999.0 0.0 -0.244 9.0 9.0 regulation of cell-cell adhesion -0.077 0.135 0.172 1.0 -0.236 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.072 0.136 -9999.0 0.0 -0.246 9.0 9.0