S1P1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer -0.031 0.111 -9999.0 0.0 -0.231 6.0 6.0 PDGFRB 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SPHK1 -0.099 0.272 -9999.0 0.0 -0.737 4.0 4.0 mol:S1P -0.086 0.235 -9999.0 0.0 -0.631 4.0 4.0 S1P1/S1P/Gi -0.066 0.123 -9999.0 0.0 -0.434 1.0 1.0 GNAO1 0.032 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB/PLCgamma1 -0.051 0.112 -9999.0 0.0 -0.395 1.0 1.0 PLCG1 -0.06 0.112 -9999.0 0.0 -0.414 1.0 1.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PDGFB-D/PDGFRB 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0 GNAI2 0.029 0.017 -9999.0 0.0 -9999.0 0.0 0.0 GNAI3 0.024 0.018 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EDG1 -0.034 0.121 -9999.0 0.0 -0.298 4.0 4.0 S1P1/S1P -0.102 0.183 -9999.0 0.0 -0.436 5.0 5.0 negative regulation of cAMP metabolic process -0.065 0.121 -9999.0 0.0 -0.423 1.0 1.0 MAPK3 -0.081 0.157 -9999.0 0.0 -0.526 2.0 2.0 calcium-dependent phospholipase C activity -0.0 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 KDR -0.032 0.139 -9999.0 0.0 -0.339 4.0 4.0 PLCB2 -0.082 0.176 -9999.0 0.0 -0.426 4.0 4.0 RAC1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.088 0.156 -9999.0 0.0 -0.371 5.0 5.0 receptor internalization -0.096 0.17 -9999.0 0.0 -0.405 5.0 5.0 PTGS2 -0.123 0.269 -9999.0 0.0 -1.025 2.0 2.0 Rac1/GTP -0.077 0.155 -9999.0 0.0 -0.404 4.0 4.0 RHOA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VEGFA -0.01 0.038 -9999.0 0.0 -0.113 3.0 3.0 negative regulation of T cell proliferation -0.065 0.121 -9999.0 0.0 -0.423 1.0 1.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ 0.031 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.081 0.157 -9999.0 0.0 -0.526 2.0 2.0 S1P1/S1P/PDGFB-D/PDGFRB -0.08 0.179 -9999.0 0.0 -0.428 4.0 4.0 ABCC1 0.035 0.002 -9999.0 0.0 -9999.0 0.0 0.0