IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.086 0.352 -9999.0 0.0 -0.855 4.0 4.0 CRP -0.087 0.356 -9999.0 0.0 -0.865 4.0 4.0 cell cycle arrest -0.123 0.452 -9999.0 0.0 -1.112 4.0 4.0 TIMP1 -0.059 0.313 -9999.0 0.0 -0.734 4.0 4.0 IL6ST 0.028 0.033 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.015 0.158 -9999.0 0.0 -0.375 3.0 3.0 AP1 0.012 0.11 -9999.0 0.0 -9999.0 0.0 0.0 GAB2 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 TNFSF11 -0.087 0.356 -9999.0 0.0 -0.865 4.0 4.0 HSP90B1 0.017 0.059 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAPK14 -0.05 0.153 -9999.0 0.0 -0.487 2.0 2.0 AKT1 0.05 0.033 -9999.0 0.0 -9999.0 0.0 0.0 FOXO1 0.051 0.033 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 -0.031 0.146 -9999.0 0.0 -0.38 3.0 3.0 mol:GTP -0.001 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.028 0.187 -9999.0 0.0 -0.446 3.0 3.0 MITF -0.029 0.15 -9999.0 0.0 -0.34 4.0 4.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 A2M -0.034 0.286 -9999.0 0.0 -1.488 1.0 1.0 CEBPB 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1/GAB family/SHP2 0.034 0.052 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.151 0.512 -9999.0 0.0 -1.265 4.0 4.0 STAT1 0.029 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CEBPD -0.159 0.486 -9999.0 0.0 -1.155 5.0 5.0 PIK3CA 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.051 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUN 0.02 0.035 -9999.0 0.0 -0.14 1.0 1.0 PIAS3/MITF -0.025 0.153 -9999.0 0.0 -0.356 3.0 3.0 MAPK11 -0.052 0.152 -9999.0 0.0 -0.487 2.0 2.0 STAT3 (dimer)/FOXO1 -0.075 0.393 -9999.0 0.0 -0.875 4.0 4.0 GRB2/SOS1/GAB family 0.01 0.152 -9999.0 0.0 -0.551 1.0 1.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.029 0.157 -9999.0 0.0 -0.476 2.0 2.0 GRB2 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 LBP -0.04 0.27 -9999.0 0.0 -0.624 4.0 4.0 PIK3R1 0.02 0.083 -9999.0 0.0 -0.404 1.0 1.0 JAK1 0.016 0.043 -9999.0 0.0 -0.121 2.0 2.0 MYC -0.075 0.39 -9999.0 0.0 -0.908 4.0 4.0 FGG -0.089 0.355 -9999.0 0.0 -0.863 4.0 4.0 macrophage differentiation -0.123 0.452 -9999.0 0.0 -1.112 4.0 4.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 0.034 0.091 -9999.0 0.0 -0.281 1.0 1.0 JUNB -0.14 0.449 -9999.0 0.0 -1.054 5.0 5.0 FOS -0.105 0.187 -9999.0 0.0 -0.308 11.0 11.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.037 0.152 -9999.0 0.0 -0.358 4.0 4.0 STAT1/PIAS1 -0.009 0.163 -9999.0 0.0 -0.402 2.0 2.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.051 0.035 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer) -0.148 0.504 -9999.0 0.0 -1.245 4.0 4.0 PRKCD -0.055 0.272 -9999.0 0.0 -0.56 5.0 5.0 IL6R 0.006 0.094 -9999.0 0.0 -0.277 2.0 2.0 SOCS3 -0.06 0.219 -9999.0 0.0 -1.068 1.0 1.0 gp130 (dimer)/JAK1/JAK1/LMO4 0.035 0.08 -9999.0 0.0 -0.266 1.0 1.0 Rac1/GTP -0.016 0.17 -9999.0 0.0 -0.406 3.0 3.0 HCK 0.005 0.092 -9999.0 0.0 -0.228 3.0 3.0 MAPKKK cascade 0.051 0.041 -9999.0 0.0 -9999.0 0.0 0.0 bone resorption -0.078 0.333 -9999.0 0.0 -0.803 4.0 4.0 IRF1 -0.087 0.356 -9999.0 0.0 -0.865 4.0 4.0 mol:GDP -0.016 0.149 -9999.0 0.0 -0.371 3.0 3.0 SOS1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.022 0.146 -9999.0 0.0 -0.376 3.0 3.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.06 0.16 -9999.0 0.0 -0.398 2.0 2.0 PTPN11 0.029 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA -0.0 0.087 -9999.0 0.0 -0.313 1.0 1.0 gp130 (dimer)/TYK2/TYK2/LMO4 0.048 0.042 -9999.0 0.0 -9999.0 0.0 0.0 gp130 (dimer)/JAK2/JAK2/LMO4 0.039 0.053 -9999.0 0.0 -9999.0 0.0 0.0 IL6 -0.003 0.068 -9999.0 0.0 -0.137 5.0 5.0 PIAS3 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPRE 0.03 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIAS1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.01 0.08 -9999.0 0.0 -0.294 1.0 1.0 LMO4 0.022 0.035 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 (dimer)/PIAS3 -0.109 0.443 -9999.0 0.0 -1.075 4.0 4.0 MCL1 0.051 0.032 -9999.0 0.0 -9999.0 0.0 0.0