Signaling events mediated by Stem cell factor receptor (c-Kit) Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations MAP4K1 -0.023 0.114 -9999.0 0.0 -0.437 1.0 1.0 CRKL -0.024 0.131 -9999.0 0.0 -0.42 2.0 2.0 HRAS 0.015 0.127 -9999.0 0.0 -0.391 2.0 2.0 mol:PIP3 -0.033 0.128 -9999.0 0.0 -0.384 2.0 2.0 SPRED1 0.006 0.093 -9999.0 0.0 -0.229 3.0 3.0 SPRED2 0.002 0.115 -9999.0 0.0 -0.404 2.0 2.0 GAB1 -0.023 0.138 -9999.0 0.0 -0.44 2.0 2.0 FOXO3 -0.021 0.133 -9999.0 0.0 -0.421 1.0 1.0 AKT1 -0.023 0.141 -9999.0 0.0 -0.454 1.0 1.0 BAD -0.015 0.128 -9999.0 0.0 -0.423 1.0 1.0 megakaryocyte differentiation -0.044 0.131 -9999.0 0.0 -0.351 2.0 2.0 GSK3B -0.022 0.133 -9999.0 0.0 -0.423 1.0 1.0 RAF1 0.01 0.106 -9999.0 0.0 -0.321 2.0 2.0 SHC1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.023 0.138 -9999.0 0.0 -0.44 2.0 2.0 STAT1 -0.072 0.3 -9999.0 0.0 -0.864 3.0 3.0 HRAS/SPRED1 0.016 0.117 -9999.0 0.0 -0.321 2.0 2.0 cell proliferation -0.023 0.135 -9999.0 0.0 -0.431 2.0 2.0 PIK3CA 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 TEC 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RPS6KB1 -0.023 0.153 -9999.0 0.0 -0.377 3.0 3.0 HRAS/SPRED2 0.01 0.12 -9999.0 0.0 -0.321 2.0 2.0 LYN/TEC/p62DOK -0.002 0.17 -9999.0 0.0 -0.394 3.0 3.0 MAPK3 0.021 0.089 0.214 1.0 -0.261 1.0 2.0 STAP1 -0.023 0.137 -9999.0 0.0 -0.438 2.0 2.0 GRAP2 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 -0.052 0.249 -9999.0 0.0 -0.698 3.0 3.0 STAT1 (dimer) -0.075 0.293 -9999.0 0.0 -0.844 3.0 3.0 mol:Gleevec -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOCS1/VAV1 0.009 0.146 -9999.0 0.0 -0.442 2.0 2.0 actin filament polymerization -0.022 0.135 -9999.0 0.0 -0.43 2.0 2.0 LYN 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAP1/STAT5A (dimer) -0.032 0.184 -9999.0 0.0 -0.598 2.0 2.0 PIK3R1 0.019 0.083 -9999.0 0.0 -0.405 1.0 1.0 CBL/CRKL/GRB2 0.017 0.132 -9999.0 0.0 -0.388 2.0 2.0 PI3K -0.001 0.16 -9999.0 0.0 -0.368 3.0 3.0 PTEN 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT/EPO/EPOR -0.064 0.342 -9999.0 0.0 -1.2 2.0 2.0 MAPK8 -0.023 0.138 -9999.0 0.0 -0.44 2.0 2.0 STAT3 (dimer) -0.022 0.135 -9999.0 0.0 -0.431 2.0 2.0 positive regulation of transcription 0.022 0.078 0.191 2.0 -0.213 1.0 3.0 mol:GDP 0.002 0.125 -9999.0 0.0 -0.384 2.0 2.0 PIK3C2B -0.023 0.138 -9999.0 0.0 -0.44 2.0 2.0 CBL/CRKL -0.006 0.134 -9999.0 0.0 -0.398 2.0 2.0 FER -0.023 0.138 -9999.0 0.0 -0.44 2.0 2.0 SH2B3 -0.023 0.137 -9999.0 0.0 -0.438 2.0 2.0 PDPK1 -0.029 0.123 -9999.0 0.0 -0.358 2.0 2.0 SNAI2 -0.029 0.144 -9999.0 0.0 -0.465 2.0 2.0 positive regulation of cell proliferation -0.058 0.227 -9999.0 0.0 -0.623 3.0 3.0 KITLG -0.009 0.119 -9999.0 0.0 -0.317 3.0 3.0 cell motility -0.058 0.227 -9999.0 0.0 -0.623 3.0 3.0 PTPN6 -0.007 0.093 -9999.0 0.0 -0.202 4.0 4.0 EPOR 0.022 0.085 -9999.0 0.0 -9999.0 0.0 0.0 STAT5A (dimer) -0.04 0.191 -9999.0 0.0 -0.604 2.0 2.0 SOCS1 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell migration 0.035 0.146 0.41 3.0 -9999.0 0.0 3.0 SOS1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EPO 0.028 0.019 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 0.002 0.092 -9999.0 0.0 -0.229 3.0 3.0 GRB10 -0.031 0.13 -9999.0 0.0 -0.327 3.0 3.0 PTPN11 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SCF/KIT -0.022 0.145 -9999.0 0.0 -0.46 2.0 2.0 GO:0007205 0.001 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 0.009 0.085 -9999.0 0.0 -0.255 2.0 2.0 CBL 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 KIT -0.066 0.36 -9999.0 0.0 -1.327 2.0 2.0 MAP2K2 0.022 0.103 0.257 2.0 -0.255 2.0 4.0 SHC/Grb2/SOS1 0.022 0.153 -9999.0 0.0 -0.418 2.0 2.0 STAT5A -0.042 0.196 -9999.0 0.0 -0.623 2.0 2.0 GRB2 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation -0.028 0.141 -9999.0 0.0 -0.455 2.0 2.0 SHC/GRAP2 0.051 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTPRO -0.045 0.133 -9999.0 0.0 -0.358 2.0 2.0 SH2B2 -0.023 0.137 -9999.0 0.0 -0.438 2.0 2.0 DOK1 0.003 0.115 -9999.0 0.0 -0.404 2.0 2.0 MATK -0.036 0.148 -9999.0 0.0 -0.418 3.0 3.0 CREBBP 0.032 0.047 -9999.0 0.0 -9999.0 0.0 0.0 BCL2 -0.032 0.314 -9999.0 0.0 -1.577 1.0 1.0