Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	306.0	51.0	-0.893	0.036	1000.0	-1000.0	-0.089	-1000.0
Ephrin A  reverse signaling	5.0	37.0	7.0	-0.104	0.003	1000.0	-1000.0	0.0	-1000.0
TCGA08_retinoblastoma	5.0	40.0	8.0	-0.061	0.097	1000.0	-1000.0	-0.006	-1000.0
E-cadherin signaling events	5.0	28.0	5.0	-0.134	0.035	1000.0	-1000.0	0.016	-1000.0
Thromboxane A2 receptor signaling	4.0	461.0	105.0	-0.247	0.046	1000.0	-1000.0	-0.034	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	289.0	68.0	-0.509	0.322	1000.0	-1000.0	-0.095	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	335.0	74.0	-0.134	0.072	1000.0	-1000.0	-0.062	-1000.0
IL23-mediated signaling events	4.0	291.0	60.0	-0.662	0.037	1000.0	-1000.0	-0.077	-1000.0
IL12-mediated signaling events	3.0	306.0	87.0	-0.391	0.054	1000.0	-1000.0	-0.052	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.039	-1000.0	1000.0	-1000.0	-0.0	-1000.0
Signaling events mediated by the Hedgehog family	3.0	183.0	52.0	-0.116	0.062	1000.0	-1000.0	-0.035	-1000.0
Ephrin B reverse signaling	3.0	164.0	48.0	-0.112	0.045	1000.0	-1000.0	-0.035	-1000.0
Endothelins	3.0	352.0	96.0	-0.326	0.047	1000.0	-1000.0	-0.043	-1000.0
Syndecan-3-mediated signaling events	3.0	124.0	35.0	-0.134	0.081	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	261.0	76.0	-0.139	0.055	1000.0	-1000.0	-0.054	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	290.0	136.0	-0.426	0.102	1000.0	-1000.0	-0.037	-1000.0
Syndecan-1-mediated signaling events	2.0	93.0	34.0	-0.179	0.035	1000.0	-1000.0	-0.018	-1000.0
Visual signal transduction: Cones	2.0	85.0	38.0	-0.062	0.043	1000.0	-1000.0	-0.0	-1000.0
HIF-1-alpha transcription factor network	2.0	192.0	76.0	-0.209	0.069	1000.0	-1000.0	-0.027	-1000.0
Arf6 signaling events	2.0	157.0	62.0	-0.075	0.074	1000.0	-1000.0	-0.014	-1000.0
PLK1 signaling events	2.0	245.0	85.0	-0.175	0.051	1000.0	-1000.0	-0.037	-1000.0
PDGFR-alpha signaling pathway	2.0	111.0	44.0	-0.243	0.044	1000.0	-1000.0	-0.024	-1000.0
IL1-mediated signaling events	2.0	134.0	62.0	-0.105	0.079	1000.0	-1000.0	-0.023	-1000.0
Nongenotropic Androgen signaling	2.0	137.0	52.0	-0.206	0.097	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	359.0	125.0	-0.103	0.059	1000.0	-1000.0	-0.03	-1000.0
Syndecan-4-mediated signaling events	2.0	151.0	67.0	-0.099	0.047	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling in keratinocytes	2.0	102.0	43.0	-0.134	0.039	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	2.0	146.0	67.0	-0.173	0.056	1000.0	-1000.0	-0.044	-1000.0
Caspase cascade in apoptosis	1.0	95.0	74.0	-0.118	0.042	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	1.0	91.0	76.0	-0.085	0.064	1000.0	-1000.0	-0.031	-1000.0
ErbB4 signaling events	1.0	80.0	69.0	-0.114	0.051	1000.0	-1000.0	-0.023	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	29.0	28.0	-0.041	0.049	1000.0	-1000.0	-0.006	-1000.0
Osteopontin-mediated events	1.0	75.0	38.0	-0.104	0.035	1000.0	-1000.0	-0.012	-1000.0
Noncanonical Wnt signaling pathway	1.0	35.0	26.0	-0.042	0.035	1000.0	-1000.0	-0.056	-1000.0
Syndecan-2-mediated signaling events	1.0	87.0	69.0	-0.062	0.051	1000.0	-1000.0	-0.028	-1000.0
Cellular roles of Anthrax toxin	1.0	67.0	39.0	-0.176	0.036	1000.0	-1000.0	-0.022	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	89.0	61.0	-0.173	0.081	1000.0	-1000.0	-0.045	-1000.0
Aurora A signaling	1.0	75.0	60.0	-0.088	0.089	1000.0	-1000.0	-0.009	-1000.0
p75(NTR)-mediated signaling	1.0	157.0	125.0	-0.179	0.081	1000.0	-1000.0	-0.026	-1000.0
IL4-mediated signaling events	1.0	135.0	91.0	-0.511	0.252	1000.0	-1000.0	-0.102	-1000.0
BMP receptor signaling	1.0	118.0	81.0	-0.065	0.075	1000.0	-1000.0	-0.021	-1000.0
EPO signaling pathway	1.0	84.0	55.0	-0.0	0.087	1000.0	-1000.0	-0.017	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	139.0	97.0	-0.105	0.06	1000.0	-1000.0	-0.054	-1000.0
amb2 Integrin signaling	1.0	109.0	82.0	-0.087	0.062	1000.0	-1000.0	-0.025	-1000.0
Nectin adhesion pathway	1.0	70.0	63.0	-0.134	0.073	1000.0	-1000.0	-0.046	-1000.0
Glucocorticoid receptor regulatory network	1.0	133.0	114.0	-0.277	0.078	1000.0	-1000.0	-0.043	-1000.0
Ceramide signaling pathway	1.0	104.0	76.0	-0.077	0.062	1000.0	-1000.0	-0.022	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	49.0	37.0	-0.093	0.06	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class III	1.0	69.0	40.0	-0.142	0.108	1000.0	-1000.0	-0.028	-1000.0
TRAIL signaling pathway	1.0	56.0	48.0	-0.004	0.063	1000.0	-1000.0	-0.019	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	163.0	82.0	-0.06	0.054	1000.0	-1000.0	-0.042	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	71.0	52.0	-0.25	0.102	1000.0	-1000.0	-0.018	-1000.0
S1P1 pathway	1.0	63.0	36.0	-0.123	0.035	1000.0	-1000.0	-0.024	-1000.0
TCGA08_p53	1.0	9.0	7.0	-0.042	0.034	1000.0	-1000.0	-0.005	-1000.0
FAS signaling pathway (CD95)	1.0	67.0	47.0	-0.049	0.049	1000.0	-1000.0	-0.038	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	76.0	44.0	-0.062	0.034	1000.0	-1000.0	-0.014	-1000.0
Integrins in angiogenesis	1.0	127.0	84.0	-0.08	0.087	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	47.0	45.0	-0.03	0.063	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	1.0	68.0	51.0	-0.173	0.08	1000.0	-1000.0	-0.032	-1000.0
EPHB forward signaling	1.0	111.0	85.0	-0.059	0.072	1000.0	-1000.0	-0.042	-1000.0
Effects of Botulinum toxin	1.0	45.0	26.0	-0.15	0.045	1000.0	-1000.0	-0.001	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	47.0	31.0	-0.105	0.046	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	1.0	56.0	51.0	-0.099	0.062	1000.0	-1000.0	-0.06	-1000.0
Wnt signaling	1.0	13.0	7.0	-0.034	0.034	1000.0	-1000.0	-0.011	-1000.0
TCGA08_rtk_signaling	1.0	26.0	26.0	-0.034	0.054	1000.0	-1000.0	-0.005	-1000.0
LPA receptor mediated events	1.0	108.0	102.0	-0.145	0.056	1000.0	-1000.0	-0.069	-1000.0
IL6-mediated signaling events	1.0	146.0	75.0	-0.159	0.051	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events	1.0	78.0	73.0	-0.083	0.046	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	1.0	193.0	99.0	-0.089	0.053	1000.0	-1000.0	-0.044	-1000.0
EGFR-dependent Endothelin signaling events	1.0	28.0	21.0	-0.028	0.069	1000.0	-1000.0	-0.001	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	127.0	88.0	-0.15	0.047	1000.0	-1000.0	-0.069	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	143.0	120.0	-0.152	0.106	1000.0	-1000.0	-0.05	-1000.0
Visual signal transduction: Rods	1.0	99.0	52.0	-0.062	0.045	1000.0	-1000.0	-0.009	-1000.0
Signaling events mediated by PRL	1.0	65.0	34.0	-0.196	0.041	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	134.0	78.0	-0.075	0.051	1000.0	-1000.0	-0.03	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	30.0	17.0	-0.039	0.037	1000.0	-1000.0	-0.013	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.049	0.01	1000.0	-1000.0	-0.009	-1000.0
ErbB2/ErbB3 signaling events	0.0	61.0	65.0	-0.064	0.048	1000.0	-1000.0	-0.071	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	3.0	23.0	0.02	0.088	1000.0	-1000.0	-0.02	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	5.0	34.0	-0.041	0.077	1000.0	-1000.0	-0.025	-1000.0
Canonical NF-kappaB pathway	0.0	15.0	39.0	-0.03	0.087	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by HDAC Class II	0.0	32.0	75.0	-0.048	0.093	1000.0	-1000.0	-0.012	-1000.0
BARD1 signaling events	0.0	56.0	57.0	-0.056	0.074	1000.0	-1000.0	-0.032	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.073	0.06	1000.0	-1000.0	-0.025	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	39.0	54.0	-0.022	0.084	1000.0	-1000.0	-0.019	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	6.0	17.0	0.0	0.072	1000.0	-1000.0	-0.024	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.011	0.035	1000.0	-1000.0	0.015	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	72.0	85.0	-0.306	0.069	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by PTP1B	0.0	58.0	76.0	-0.035	0.054	1000.0	-1000.0	-0.051	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	49.0	65.0	-0.046	0.067	1000.0	-1000.0	-0.035	-1000.0
Arf6 downstream pathway	0.0	6.0	43.0	-0.05	0.073	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	0.0	2.0	7.0	0.0	0.024	1000.0	-1000.0	-0.007	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	15.0	46.0	-0.053	0.055	1000.0	-1000.0	-0.067	-1000.0
Glypican 1 network	0.0	39.0	48.0	-0.04	0.064	1000.0	-1000.0	-0.019	-1000.0
Insulin-mediated glucose transport	0.0	7.0	32.0	-0.0	0.048	1000.0	-1000.0	-0.02	-1000.0
mTOR signaling pathway	0.0	17.0	53.0	-0.115	0.049	1000.0	-1000.0	-0.05	-1000.0
IFN-gamma pathway	0.0	41.0	68.0	-0.048	0.062	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	20.0	68.0	-0.049	0.063	1000.0	-1000.0	-0.031	-1000.0
Reelin signaling pathway	0.0	28.0	56.0	-0.047	0.089	1000.0	-1000.0	-0.019	-1000.0
S1P5 pathway	0.0	0.0	17.0	-0.014	0.035	1000.0	-1000.0	-0.004	-1000.0
ceramide signaling pathway	0.0	42.0	49.0	-0.03	0.051	1000.0	-1000.0	-0.027	-1000.0
HIF-2-alpha transcription factor network	0.0	28.0	43.0	-0.11	0.112	1000.0	-1000.0	-0.042	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	49.0	83.0	-0.024	0.074	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class I	0.0	33.0	104.0	-0.042	0.068	1000.0	-1000.0	-0.024	-1000.0
FoxO family signaling	0.0	28.0	64.0	-0.102	0.071	1000.0	-1000.0	-0.054	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	13.0	15.0	-0.054	0.035	1000.0	-1000.0	-0.016	-1000.0
Retinoic acid receptors-mediated signaling	0.0	37.0	58.0	-0.06	0.069	1000.0	-1000.0	-0.025	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	30.0	36.0	-0.093	0.067	1000.0	-1000.0	-0.03	-1000.0
Atypical NF-kappaB pathway	0.0	14.0	31.0	-0.01	0.049	1000.0	-1000.0	-0.008	-1000.0
IL2 signaling events mediated by PI3K	0.0	18.0	58.0	-0.001	0.061	1000.0	-1000.0	-0.04	-1000.0
TCR signaling in naïve CD8+ T cells	0.0	90.0	93.0	-0.106	0.124	1000.0	-1000.0	-0.047	-1000.0
Regulation of p38-alpha and p38-beta	0.0	43.0	54.0	-0.036	0.084	1000.0	-1000.0	-0.027	-1000.0
Glypican 2 network	0.0	2.0	4.0	-0.0	0.017	1000.0	-1000.0	-0.0	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	0.0	0.084	1000.0	-1000.0	-0.019	-1000.0
IL2 signaling events mediated by STAT5	0.0	16.0	22.0	-0.076	0.04	1000.0	-1000.0	-0.03	-1000.0
Arf6 trafficking events	0.0	15.0	71.0	-0.049	0.051	1000.0	-1000.0	-0.021	-1000.0
Regulation of Telomerase	0.0	87.0	102.0	-0.132	0.09	1000.0	-1000.0	-0.052	-1000.0
IGF1 pathway	0.0	18.0	57.0	-0.029	0.089	1000.0	-1000.0	-0.031	-1000.0
Insulin Pathway	0.0	44.0	74.0	-0.041	0.077	1000.0	-1000.0	-0.027	-1000.0
Plasma membrane estrogen receptor signaling	0.0	80.0	86.0	-0.057	0.049	1000.0	-1000.0	-0.04	-1000.0
VEGFR1 specific signals	0.0	18.0	56.0	-0.017	0.067	1000.0	-1000.0	-0.028	-1000.0
S1P3 pathway	0.0	12.0	42.0	-0.029	0.049	1000.0	-1000.0	-0.027	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	16.0	33.0	-0.051	0.09	1000.0	-1000.0	-0.034	-1000.0
Rapid glucocorticoid signaling	0.0	19.0	20.0	-0.095	0.026	1000.0	-1000.0	-0.001	-1000.0
PDGFR-beta signaling pathway	0.0	94.0	97.0	-0.078	0.094	1000.0	-1000.0	-0.031	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.034	0.034	1000.0	-1000.0	-0.02	-1000.0
S1P4 pathway	0.0	2.0	25.0	-0.0	0.049	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	0.0	38.0	44.0	-0.039	0.063	1000.0	-1000.0	-0.022	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.002	0.046	1000.0	-1000.0	-0.01	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	0.0	0.066	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	53.0	70.0	-0.183	0.06	1000.0	-1000.0	-0.059	-1000.0
Total	132	11024	7203	-14.1286439921	-991.684345447	131000	-131000	-3.89396913407	-131000