BMP receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BMP7/BMPR2/BMPR1A-1B/FS -0.044 0.135 -9999.0 0.0 -0.685 1.0 1.0 SMAD6-7/SMURF1 -0.025 0.1 -9999.0 0.0 -0.501 1.0 1.0 NOG -0.025 0.164 -9999.0 0.0 -0.65 2.0 2.0 SMAD9 -0.059 0.186 -9999.0 0.0 -0.595 3.0 3.0 SMAD4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD5 -0.042 0.122 -9999.0 0.0 -0.476 1.0 1.0 BMP7/USAG1 -0.265 0.284 -9999.0 0.0 -0.53 16.0 16.0 SMAD5/SKI -0.031 0.116 -9999.0 0.0 -0.446 1.0 1.0 SMAD1 0.032 0.052 -9999.0 0.0 -9999.0 0.0 0.0 BMP2 -0.249 0.35 -9999.0 0.0 -0.691 12.0 12.0 SMAD1/SMAD1/SMAD4 -0.02 0.062 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1B -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 BMPR1A-1B/BAMBI -0.113 0.176 -9999.0 0.0 -0.501 3.0 3.0 AHSG -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 CER1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CER1 -0.215 0.273 -9999.0 0.0 -0.595 9.0 9.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.055 0.164 -9999.0 0.0 -0.638 1.0 1.0 BMP2-4 (homodimer) -0.25 0.313 -9999.0 0.0 -0.572 14.0 14.0 RGMB 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/BMPR2/BMPR1A-1B -0.07 0.138 -9999.0 0.0 -0.453 2.0 2.0 RGMA -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 SMURF1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.069 0.16 -9999.0 0.0 -0.506 2.0 2.0 BMP2-4/USAG1 -0.412 0.401 -9999.0 0.0 -0.777 15.0 15.0 SMAD6/SMURF1/SMAD5 -0.031 0.116 -9999.0 0.0 -0.446 1.0 1.0 SOSTDC1 -0.324 0.352 -9999.0 0.0 -0.665 16.0 16.0 BMP7/BMPR2/BMPR1A-1B -0.025 0.077 -9999.0 0.0 -9999.0 0.0 0.0 SKI 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6 (homodimer) -0.101 0.249 -9999.0 0.0 -0.607 6.0 6.0 HFE2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZFYVE16 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/CHRD -0.242 0.281 -9999.0 0.0 -0.626 9.0 9.0 SMAD5/SMAD5/SMAD4 -0.031 0.116 -9999.0 0.0 -0.446 1.0 1.0 MAPK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/TAB family -0.079 0.129 -9999.0 0.0 -0.499 2.0 2.0 BMP7 (homodimer) -0.018 0.131 -9999.0 0.0 -0.525 2.0 2.0 NUP214 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP6/FETUA -0.101 0.198 -9999.0 0.0 -0.462 7.0 7.0 SMAD1/SKI 0.04 0.05 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 CTDSP2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/FETUA -0.229 0.299 -9999.0 0.0 -0.646 9.0 9.0 MAP3K7IP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GREM1 -0.166 0.32 -9999.0 0.0 -0.712 8.0 8.0 BMPR2 (homodimer) 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GADD34/PP1CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMPR1A-1B (homodimer) -0.012 0.064 -9999.0 0.0 -0.37 1.0 1.0 CHRDL1 -0.101 0.249 -9999.0 0.0 -0.608 6.0 6.0 ENDOFIN/SMAD1 0.04 0.05 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6-7/SMURF1/SMAD1 -0.021 0.074 -9999.0 0.0 -9999.0 0.0 0.0 SMAD6/SMURF1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BAMBI -0.159 0.288 -9999.0 0.0 -0.608 9.0 9.0 SMURF2 -0.059 0.203 -9999.0 0.0 -0.588 4.0 4.0 BMP2-4/CHRDL1 -0.282 0.303 -9999.0 0.0 -0.659 10.0 10.0 BMP2-4/GREM1 -0.323 0.339 -9999.0 0.0 -0.68 13.0 13.0 SMAD7 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 SMAD8A/SMAD8A/SMAD4 -0.047 0.176 -9999.0 0.0 -0.553 3.0 3.0 SMAD1/SMAD6 0.04 0.05 -9999.0 0.0 -9999.0 0.0 0.0 TAK1/SMAD6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP7 -0.018 0.131 -9999.0 0.0 -0.526 2.0 2.0 BMP6 -0.101 0.249 -9999.0 0.0 -0.608 6.0 6.0 MAP3K7IP2 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.058 0.147 -9999.0 0.0 -0.578 1.0 1.0 PPM1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMAD1/SMURF2 0.001 0.127 -9999.0 0.0 -0.428 1.0 1.0 SMAD7/SMURF1 -0.012 0.064 -9999.0 0.0 -0.37 1.0 1.0 CTDSPL -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 PPP1CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XIAP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTDSP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PPP1R15A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.077 0.178 -9999.0 0.0 -0.564 2.0 2.0 CHRD -0.035 0.158 -9999.0 0.0 -0.526 3.0 3.0 BMPR2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BMP2-4/BMPR2/BMPR1A-1B/RGM -0.081 0.177 -9999.0 0.0 -0.545 2.0 2.0 BMP4 -0.076 0.218 -9999.0 0.0 -0.575 5.0 5.0 FST -0.025 0.164 -9999.0 0.0 -0.65 2.0 2.0 BMP2-4/NOG -0.24 0.282 -9999.0 0.0 -0.587 11.0 11.0 BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.022 0.07 -9999.0 0.0 -9999.0 0.0 0.0