Ceramide signaling pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations SPHK2 -0.051 0.22 -9999.0 0.0 -0.606 4.0 4.0 MAP4K4 -0.009 0.137 -9999.0 0.0 -0.513 1.0 1.0 BAG4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PKC zeta/ceramide -0.008 0.072 0.188 2.0 -9999.0 0.0 2.0 NFKBIA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BIRC3 -0.133 0.288 -9999.0 0.0 -0.667 7.0 7.0 BAX 0.008 0.041 -9999.0 0.0 -9999.0 0.0 0.0 RIPK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.026 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BAD 0.004 0.076 0.214 2.0 -9999.0 0.0 2.0 SMPD1 -0.012 0.099 -9999.0 0.0 -0.274 2.0 2.0 RB1 0.004 0.076 0.229 1.0 -9999.0 0.0 1.0 FADD/Caspase 8 0.014 0.105 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 0.004 0.072 -9999.0 0.0 -9999.0 0.0 0.0 NSMAF -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 response to UV 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAF1 0.012 0.072 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.126 0.274 -9999.0 0.0 -0.632 7.0 7.0 mol:ceramide -0.007 0.083 0.223 2.0 -9999.0 0.0 2.0 MADD 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to oxidative stress 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Free Fatty acid -0.061 0.21 -9999.0 0.0 -0.542 5.0 5.0 ASAH1 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 negative regulation of cell cycle 0.003 0.076 0.228 1.0 -9999.0 0.0 1.0 cell proliferation 0.009 0.048 -9999.0 0.0 -9999.0 0.0 0.0 BID -0.05 0.214 -9999.0 0.0 -0.644 3.0 3.0 MAP3K1 -0.005 0.076 0.229 1.0 -9999.0 0.0 1.0 EIF2A 0.005 0.095 -9999.0 0.0 -9999.0 0.0 0.0 TRADD 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRADD 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK3 0.026 0.068 -9999.0 0.0 -9999.0 0.0 0.0 response to heat 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.026 0.068 -9999.0 0.0 -9999.0 0.0 0.0 Cathepsin D/ceramide -0.026 0.14 0.213 1.0 -0.492 2.0 3.0 FADD -0.001 0.111 -9999.0 0.0 -9999.0 0.0 0.0 KSR1 0.004 0.076 0.214 2.0 -9999.0 0.0 2.0 MAPK8 0.007 0.067 0.207 2.0 -9999.0 0.0 2.0 PRKRA 0.004 0.076 0.214 2.0 -9999.0 0.0 2.0 PDGFA -0.075 0.244 -9999.0 0.0 -0.712 4.0 4.0 TRAF2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 mol:GD3 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ganglioside biosynthetic process -0.007 0.083 0.223 2.0 -9999.0 0.0 2.0 CTSD -0.033 0.191 -9999.0 0.0 -0.773 2.0 2.0 regulation of nitric oxide biosynthetic process 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 response to radiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ERK1/PKC delta 0.01 0.051 -9999.0 0.0 -9999.0 0.0 0.0 PRKCD 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCZ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GW4869 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:sphingosine -0.061 0.21 -9999.0 0.0 -0.542 5.0 5.0 RelA/NF kappa B1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:glutathione -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAWR -0.033 0.191 -9999.0 0.0 -0.773 2.0 2.0 TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.011 0.118 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4/TNF-alpha -0.025 0.1 -9999.0 0.0 -0.501 1.0 1.0 mol:Sphingosine-1-phosphate -0.051 0.219 -9999.0 0.0 -0.604 4.0 4.0 MAP2K1 0.021 0.069 -9999.0 0.0 -9999.0 0.0 0.0 mol:C11AG 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYCS 0.016 0.06 0.173 1.0 -9999.0 0.0 1.0 TNFRSF1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TNFR1A/BAG4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EIF2AK2 0.004 0.087 -9999.0 0.0 -0.264 1.0 1.0 TNF-alpha/TNFR1A/FAN -0.041 0.13 -9999.0 0.0 -0.501 2.0 2.0 response to hydrogen peroxide 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP8 0.018 0.069 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K2 0.021 0.069 -9999.0 0.0 -9999.0 0.0 0.0 SMPD3 -0.001 0.081 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.025 0.164 -9999.0 0.0 -0.65 2.0 2.0 PKC zeta/PAR4 -0.037 0.144 -9999.0 0.0 -0.596 2.0 2.0 mol:PHOSPHOCHOLINE 0.052 0.11 0.226 8.0 -9999.0 0.0 8.0 NF kappa B1/RelA/I kappa B alpha -0.027 0.103 -9999.0 0.0 -0.427 2.0 2.0 AIFM1 0.016 0.06 0.173 1.0 -9999.0 0.0 1.0 BCL2 -0.035 0.158 -9999.0 0.0 -0.526 3.0 3.0