EPHB forward signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Ephrin A5/EPHB2 -0.081 0.159 -9999.0 0.0 -0.37 7.0 7.0 cell-cell adhesion 0.134 0.195 0.563 3.0 -9999.0 0.0 3.0 Ephrin B/EPHB2/RasGAP -0.112 0.202 -9999.0 0.0 -0.599 3.0 3.0 ITSN1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHC1 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 Ephrin B1/EPHB3 -0.032 0.124 -9999.0 0.0 -0.511 2.0 2.0 Ephrin B1/EPHB1 -0.086 0.194 -9999.0 0.0 -0.459 6.0 6.0 HRAS/GDP -0.096 0.156 -9999.0 0.0 -0.563 1.0 1.0 Ephrin B/EPHB1/GRB7 -0.109 0.181 -9999.0 0.0 -0.509 4.0 4.0 Endophilin/SYNJ1 -0.064 0.187 -9999.0 0.0 -0.479 3.0 3.0 KRAS -0.018 0.131 -9999.0 0.0 -0.526 2.0 2.0 Ephrin B/EPHB1/Src -0.109 0.181 -9999.0 0.0 -0.509 4.0 4.0 endothelial cell migration -0.052 0.111 -9999.0 0.0 -0.424 1.0 1.0 GRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAK1 -0.056 0.19 -9999.0 0.0 -0.479 3.0 3.0 HRAS 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RRAS -0.079 0.198 -9999.0 0.0 -0.488 3.0 3.0 DNM1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell-cell signaling 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.071 0.192 -9999.0 0.0 -0.57 2.0 2.0 lamellipodium assembly -0.134 0.195 -9999.0 0.0 -0.563 3.0 3.0 Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.039 0.137 -9999.0 0.0 -0.419 1.0 1.0 PIK3R1 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 EPHB2 -0.093 0.231 -9999.0 0.0 -0.567 6.0 6.0 EPHB3 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 EPHB1 -0.101 0.249 -9999.0 0.0 -0.608 6.0 6.0 EPHB4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.088 0.153 -9999.0 0.0 -0.488 1.0 1.0 Ephrin B/EPHB2 -0.107 0.183 -9999.0 0.0 -0.484 5.0 5.0 Ephrin B/EPHB3 -0.066 0.13 -9999.0 0.0 -0.429 2.0 2.0 JNK cascade -0.095 0.222 -9999.0 0.0 -0.533 5.0 5.0 Ephrin B/EPHB1 -0.111 0.185 -9999.0 0.0 -0.518 4.0 4.0 RAP1/GDP -0.073 0.132 -9999.0 0.0 -9999.0 0.0 0.0 EFNB2 -0.068 0.197 -9999.0 0.0 -0.526 5.0 5.0 EFNB3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EFNB1 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 Ephrin B2/EPHB1-2 -0.164 0.232 -9999.0 0.0 -0.555 7.0 7.0 RAP1B 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.138 0.204 -9999.0 0.0 -0.596 3.0 3.0 Rap1/GTP -0.134 0.197 -9999.0 0.0 -0.572 3.0 3.0 axon guidance -0.081 0.158 -9999.0 0.0 -0.369 7.0 7.0 MAPK3 -0.016 0.124 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.016 0.124 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.041 0.162 -9999.0 0.0 -0.442 1.0 1.0 actin cytoskeleton reorganization -0.114 0.156 -9999.0 0.0 -0.468 3.0 3.0 CDC42/GDP -0.041 0.162 -9999.0 0.0 -0.442 1.0 1.0 PI3K -0.052 0.112 -9999.0 0.0 -0.429 1.0 1.0 EFNA5 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 Ephrin B2/EPHB4 -0.049 0.114 -9999.0 0.0 -0.314 5.0 5.0 Ephrin B/EPHB2/Intersectin/N-WASP -0.034 0.137 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP -0.152 0.203 -9999.0 0.0 -0.617 3.0 3.0 PTK2 0.031 0.045 -9999.0 0.0 -9999.0 0.0 0.0 MAP4K4 -0.097 0.225 -9999.0 0.0 -0.54 5.0 5.0 SRC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KALRN 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Intersectin/N-WASP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 neuron projection morphogenesis -0.042 0.187 -9999.0 0.0 -0.442 1.0 1.0 MAP2K1 -0.027 0.13 -9999.0 0.0 -0.388 1.0 1.0 WASL 0.016 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin B1/EPHB1-2/NCK1 -0.132 0.209 -9999.0 0.0 -0.589 4.0 4.0 cell migration -0.02 0.138 -9999.0 0.0 -0.395 1.0 1.0 NRAS -0.018 0.131 -9999.0 0.0 -0.526 2.0 2.0 SYNJ1 -0.065 0.19 -9999.0 0.0 -0.488 3.0 3.0 PXN 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TF -0.107 0.23 -9999.0 0.0 -0.629 2.0 2.0 HRAS/GTP -0.145 0.212 -9999.0 0.0 -0.525 6.0 6.0 Ephrin B1/EPHB1-2 -0.135 0.213 -9999.0 0.0 -0.598 4.0 4.0 cell adhesion mediated by integrin 0.048 0.119 0.398 1.0 -9999.0 0.0 1.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.157 0.229 -9999.0 0.0 -0.566 6.0 6.0 RAC1-CDC42/GTP -0.142 0.196 -9999.0 0.0 -0.566 3.0 3.0 RASA1 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 RAC1-CDC42/GDP -0.073 0.132 -9999.0 0.0 -9999.0 0.0 0.0 ruffle organization -0.085 0.231 -9999.0 0.0 -0.573 3.0 3.0 NCK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 receptor internalization -0.052 0.182 -9999.0 0.0 -0.457 3.0 3.0 Ephrin B/EPHB2/KALRN -0.104 0.179 -9999.0 0.0 -0.512 3.0 3.0 ROCK1 0.001 0.119 -9999.0 0.0 -0.46 2.0 2.0 RAS family/GDP -0.111 0.154 -9999.0 0.0 -0.586 1.0 1.0 Rac1/GTP -0.142 0.209 -9999.0 0.0 -0.607 3.0 3.0 Ephrin B/EPHB1/Src/Paxillin -0.039 0.142 -9999.0 0.0 -0.481 1.0 1.0