Fc-epsilon receptor I signaling in mast cells Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PPAP2A -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 LAT2 -0.169 0.251 -9999.0 0.0 -0.632 5.0 5.0 AP1 -0.214 0.246 -9999.0 0.0 -0.621 6.0 6.0 mol:PIP3 -0.193 0.271 -9999.0 0.0 -0.663 5.0 5.0 IKBKB -0.089 0.144 -9999.0 0.0 -0.319 4.0 4.0 AKT1 -0.193 0.28 -9999.0 0.0 -0.684 5.0 5.0 IKBKG -0.089 0.144 -9999.0 0.0 -0.319 4.0 4.0 MS4A2 -0.245 0.343 -9999.0 0.0 -0.676 12.0 12.0 mol:Sphingosine-1-phosphate 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.015 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K1 -0.127 0.213 -9999.0 0.0 -0.524 4.0 4.0 mol:Ca2+ -0.139 0.198 -9999.0 0.0 -0.46 5.0 5.0 LYN 0.011 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CBLB -0.167 0.248 -9999.0 0.0 -0.625 5.0 5.0 SHC1 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 RasGAP/p62DOK -0.06 0.145 -9999.0 0.0 -0.462 3.0 3.0 positive regulation of cell migration -0.005 0.106 -9999.0 0.0 -0.596 1.0 1.0 INPP5D 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLD2 -0.26 0.319 -9999.0 0.0 -0.595 12.0 12.0 PTPN13 -0.263 0.295 -9999.0 0.0 -0.591 12.0 12.0 PTPN11 0.008 0.011 -9999.0 0.0 -9999.0 0.0 0.0 GO:0007205 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of mast cell degranulation -0.103 0.184 -9999.0 0.0 -0.425 4.0 4.0 SYK -0.014 0.138 -9999.0 0.0 -0.781 1.0 1.0 GRB2 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LAT/PLCgamma1/GRB2/SLP76/GADs -0.236 0.247 -9999.0 0.0 -0.693 5.0 5.0 LAT -0.167 0.248 -9999.0 0.0 -0.625 5.0 5.0 PAK2 -0.144 0.249 -9999.0 0.0 -0.616 4.0 4.0 NFATC2 -0.087 0.082 -9999.0 0.0 -9999.0 0.0 0.0 HRAS -0.17 0.285 -9999.0 0.0 -0.586 7.0 7.0 GAB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLA2G1B 0.032 0.044 -9999.0 0.0 -9999.0 0.0 0.0 Fc epsilon R1 -0.35 0.364 -9999.0 0.0 -0.696 14.0 14.0 Antigen/IgE/Fc epsilon R1 -0.323 0.341 -9999.0 0.0 -0.645 14.0 14.0 mol:GDP -0.185 0.308 -9999.0 0.0 -0.639 7.0 7.0 JUN -0.058 0.23 -9999.0 0.0 -0.773 3.0 3.0 mol:Ca++ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.01 0.138 -9999.0 0.0 -0.78 1.0 1.0 FOS -0.076 0.218 -9999.0 0.0 -0.575 5.0 5.0 Antigen/IgE/Fc epsilon R1/LYN/SYK -0.186 0.262 -9999.0 0.0 -0.57 7.0 7.0 CHUK -0.089 0.144 -9999.0 0.0 -0.319 4.0 4.0 KLRG1 -0.167 0.242 -9999.0 0.0 -0.605 5.0 5.0 VAV1 -0.181 0.261 -9999.0 0.0 -0.62 6.0 6.0 calcium-dependent protein kinase C activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CBL -0.167 0.248 -9999.0 0.0 -0.625 5.0 5.0 negative regulation of mast cell degranulation -0.173 0.206 -9999.0 0.0 -0.557 5.0 5.0 BTK -0.193 0.329 -9999.0 0.0 -0.724 6.0 6.0 Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK -0.281 0.359 -9999.0 0.0 -0.673 12.0 12.0 GAB2/PI3K/SHP2 -0.252 0.293 -9999.0 0.0 -0.787 5.0 5.0 Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.197 0.27 -9999.0 0.0 -0.65 6.0 6.0 RAF1 0.043 0.033 -9999.0 0.0 -9999.0 0.0 0.0 Fc epsilon R1/FcgammaRIIB/SHIP -0.343 0.348 -9999.0 0.0 -0.683 14.0 14.0 FCER1G -0.006 0.143 -9999.0 0.0 -0.8 1.0 1.0 FCER1A -0.305 0.351 -9999.0 0.0 -0.667 15.0 15.0 Antigen/IgE/Fc epsilon R1/Fyn -0.299 0.322 -9999.0 0.0 -0.602 14.0 14.0 MAPK3 0.053 0.028 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.053 0.028 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK8 -0.019 0.064 -9999.0 0.0 -9999.0 0.0 0.0 DUSP1 -0.075 0.244 -9999.0 0.0 -0.712 4.0 4.0 NF-kappa-B/RelA -0.067 0.065 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton reorganization -0.158 0.241 -9999.0 0.0 -0.607 5.0 5.0 mol:Glucocorticoid Dexamethasone 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.182 0.25 -9999.0 0.0 -0.63 5.0 5.0 FER -0.167 0.248 -9999.0 0.0 -0.625 5.0 5.0 RELA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ITK -0.079 0.177 -9999.0 0.0 -0.742 2.0 2.0 SOS1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 -0.182 0.301 -9999.0 0.0 -0.622 7.0 7.0 cytokine secretion -0.049 0.047 -9999.0 0.0 -9999.0 0.0 0.0 SPHK1 -0.214 0.26 -9999.0 0.0 -0.607 7.0 7.0 PTK2 -0.166 0.257 -9999.0 0.0 -0.645 5.0 5.0 NTAL/PLCgamma1/GRB2/SLP76/GADs -0.249 0.263 -9999.0 0.0 -0.738 5.0 5.0 EDG1 -0.005 0.106 -9999.0 0.0 -0.597 1.0 1.0 mol:DAG -0.19 0.268 -9999.0 0.0 -0.612 6.0 6.0 MAP2K2 0.048 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 0.048 0.029 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KLRG1/SHP2 -0.174 0.21 -9999.0 0.0 -0.559 5.0 5.0 MAP2K4 0.016 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Fc epsilon R1/FcgammaRIIB -0.361 0.364 -9999.0 0.0 -0.718 14.0 14.0 mol:Choline -0.254 0.31 -9999.0 0.0 -0.582 12.0 12.0 SHC/Grb2/SOS1 -0.177 0.218 -9999.0 0.0 -0.586 5.0 5.0 FYN 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DOK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PXN -0.145 0.232 -9999.0 0.0 -0.578 5.0 5.0 HCLS1 -0.192 0.291 -9999.0 0.0 -0.646 6.0 6.0 PRKCB -0.137 0.196 -9999.0 0.0 -0.45 5.0 5.0 FCGR2B -0.067 0.225 -9999.0 0.0 -0.65 4.0 4.0 IGHE -0.006 0.009 -9999.0 0.0 -9999.0 0.0 0.0 KLRG1/SHIP -0.177 0.213 -9999.0 0.0 -0.574 5.0 5.0 LCP2 -0.009 0.138 -9999.0 0.0 -0.777 1.0 1.0 PLA2G4A -0.29 0.315 -9999.0 0.0 -0.617 12.0 12.0 RASA1 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 mol:Phosphatidic acid -0.254 0.31 -9999.0 0.0 -0.582 12.0 12.0 IKK complex -0.052 0.115 -9999.0 0.0 -0.255 1.0 1.0 WIPF1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0