Cellular roles of Anthrax toxin Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ANTXR1 -0.025 0.164 -9999.0 0.0 -0.65 2.0 2.0 ANTXR2 -0.025 0.164 -9999.0 0.0 -0.65 2.0 2.0 negative regulation of myeloid dendritic cell antigen processing and presentation -0.01 0.027 -9999.0 0.0 -0.08 4.0 4.0 monocyte activation -0.04 0.213 -9999.0 0.0 -0.783 2.0 2.0 MAP2K2 -0.004 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K1 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K7 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K6 -0.025 0.068 -9999.0 0.0 -0.273 2.0 2.0 CYAA -0.028 0.128 -9999.0 0.0 -0.355 4.0 4.0 MAP2K4 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 IL1B -0.081 0.171 -9999.0 0.0 -0.363 8.0 8.0 Channel -0.047 0.129 -9999.0 0.0 -0.378 4.0 4.0 NLRP1 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CALM1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 negative regulation of phagocytosis -0.011 0.031 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of endothelial cell proliferation 0.01 0.027 0.08 4.0 -9999.0 0.0 4.0 MAPK3 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PGR -0.008 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PA/Cellular Receptors -0.052 0.141 -9999.0 0.0 -0.412 4.0 4.0 apoptosis -0.01 0.027 -9999.0 0.0 -0.08 4.0 4.0 LOC728358 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Lethal toxin (unfolded) -0.026 0.126 -9999.0 0.0 -0.347 4.0 4.0 macrophage activation 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 TNF -0.025 0.164 -9999.0 0.0 -0.65 2.0 2.0 VCAM1 -0.04 0.217 -9999.0 0.0 -0.794 2.0 2.0 platelet activation -0.011 0.031 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade -0.005 0.032 -9999.0 0.0 -9999.0 0.0 0.0 IL18 -0.041 0.145 -9999.0 0.0 -0.408 4.0 4.0 negative regulation of macrophage activation -0.01 0.027 -9999.0 0.0 -0.08 4.0 4.0 LEF -0.01 0.027 -9999.0 0.0 -0.081 4.0 4.0 CASP1 -0.01 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:cAMP -0.011 0.031 -9999.0 0.0 -9999.0 0.0 0.0 necrosis -0.01 0.027 -9999.0 0.0 -0.08 4.0 4.0 intracellular pH reduction -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAGA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Edema toxin (unfolded) -0.027 0.129 -9999.0 0.0 -0.357 4.0 4.0 mol:Epigallocatechin-3-gallate (EGCG) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0