Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.238 0.335 -9999.0 0.0 -0.845 4.0 4.0 IHH -0.027 0.061 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.146 0.236 -9999.0 0.0 -0.517 8.0 8.0 LRPAP1 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 dorsoventral neural tube patterning 0.145 0.233 0.512 8.0 -9999.0 0.0 8.0 SMO/beta Arrestin2 -0.101 0.204 -9999.0 0.0 -0.862 1.0 1.0 SMO -0.115 0.215 -9999.0 0.0 -0.921 1.0 1.0 AKT1 -0.041 0.128 -9999.0 0.0 -0.525 1.0 1.0 ARRB2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.113 0.211 -9999.0 0.0 -0.897 1.0 1.0 STIL -0.151 0.247 -9999.0 0.0 -0.722 3.0 3.0 DHH N/PTCH2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.098 0.183 -9999.0 0.0 -0.734 1.0 1.0 PIK3CA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.35 0.467 -9999.0 0.0 -0.96 10.0 10.0 determination of left/right symmetry -0.113 0.211 -9999.0 0.0 -0.897 1.0 1.0 PIK3R1 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 skeletal system development -0.345 0.46 -9999.0 0.0 -0.945 10.0 10.0 IHH N/Hhip -0.227 0.288 -9999.0 0.0 -0.563 13.0 13.0 DHH N/Hhip -0.204 0.256 -9999.0 0.0 -0.503 13.0 13.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.113 0.211 -9999.0 0.0 -0.897 1.0 1.0 pancreas development -0.265 0.349 -9999.0 0.0 -0.677 13.0 13.0 HHAT -0.058 0.23 -9999.0 0.0 -0.773 3.0 3.0 PI3K -0.018 0.102 -9999.0 0.0 -0.586 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.141 0.302 -9999.0 0.0 -0.703 7.0 7.0 somite specification -0.113 0.211 -9999.0 0.0 -0.897 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.131 0.237 -9999.0 0.0 -0.81 2.0 2.0 SHH Np/Cholesterol/PTCH2 -0.058 0.152 -9999.0 0.0 -0.461 4.0 4.0 SHH Np/Cholesterol/Megalin -0.164 0.25 -9999.0 0.0 -0.551 8.0 8.0 SHH -0.048 0.203 -9999.0 0.0 -0.586 4.0 4.0 catabolic process -0.121 0.205 -9999.0 0.0 -0.807 1.0 1.0 SMO/Vitamin D3 -0.131 0.245 -9999.0 0.0 -0.813 2.0 2.0 SHH Np/Cholesterol/Hhip -0.214 0.287 -9999.0 0.0 -0.61 9.0 9.0 LRP2 -0.175 0.312 -9999.0 0.0 -0.663 9.0 9.0 receptor-mediated endocytosis -0.216 0.245 -9999.0 0.0 -0.771 4.0 4.0 SHH Np/Cholesterol/BOC -0.066 0.157 -9999.0 0.0 -0.461 4.0 4.0 SHH Np/Cholesterol/CDO -0.075 0.183 -9999.0 0.0 -0.529 4.0 4.0 mesenchymal cell differentiation 0.212 0.284 0.603 9.0 -9999.0 0.0 9.0 mol:Vitamin D3 -0.13 0.238 -9999.0 0.0 -0.809 2.0 2.0 IHH N/PTCH2 0.005 0.03 -9999.0 0.0 -9999.0 0.0 0.0 CDON -0.018 0.131 -9999.0 0.0 -0.526 2.0 2.0 IHH N/PTCH1 -0.122 0.206 -9999.0 0.0 -0.812 1.0 1.0 Megalin/LRPAP1 -0.149 0.23 -9999.0 0.0 -0.478 10.0 10.0 PTCH2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.059 0.156 -9999.0 0.0 -0.471 4.0 4.0 PTCH1 -0.122 0.205 -9999.0 0.0 -0.811 1.0 1.0 HHIP -0.266 0.35 -9999.0 0.0 -0.678 13.0 13.0