LPA receptor mediated events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GNB1/GNG2 -0.032 0.133 -9999.0 0.0 -0.73 1.0 1.0 NF kappa B1 p50/RelA/I kappa B alpha 0.004 0.073 -9999.0 0.0 -9999.0 0.0 0.0 AP1 -0.099 0.182 -9999.0 0.0 -0.479 4.0 4.0 mol:PIP3 -0.133 0.206 -9999.0 0.0 -0.47 7.0 7.0 AKT1 -0.003 0.161 -9999.0 0.0 -0.527 2.0 2.0 PTK2B -0.001 0.057 -9999.0 0.0 -0.185 2.0 2.0 RHOA -0.007 0.109 -9999.0 0.0 -0.509 1.0 1.0 PIK3CB -0.008 0.137 -9999.0 0.0 -0.771 1.0 1.0 mol:Ca2+ -0.011 0.095 -9999.0 0.0 -0.403 1.0 1.0 MAGI3 -0.05 0.209 -9999.0 0.0 -0.691 3.0 3.0 RELA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis -0.002 0.066 -9999.0 0.0 -0.258 1.0 1.0 HRAS/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of microtubule depolymerization 0.004 0.086 -9999.0 0.0 -0.382 1.0 1.0 NF kappa B1 p50/RelA -0.035 0.085 -9999.0 0.0 -9999.0 0.0 0.0 endothelial cell migration -0.036 0.195 -9999.0 0.0 -0.622 3.0 3.0 ADCY4 0.01 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ADCY5 0.003 0.096 -9999.0 0.0 -9999.0 0.0 0.0 ADCY6 0.003 0.094 -9999.0 0.0 -9999.0 0.0 0.0 ADCY7 0.006 0.089 -9999.0 0.0 -9999.0 0.0 0.0 ADCY1 0.01 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ADCY2 0.01 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ADCY3 0.01 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ADCY8 0.006 0.089 -9999.0 0.0 -9999.0 0.0 0.0 ADCY9 0.003 0.097 -9999.0 0.0 -9999.0 0.0 0.0 GSK3B 0.008 0.054 -9999.0 0.0 -9999.0 0.0 0.0 arachidonic acid secretion 0.012 0.1 -9999.0 0.0 -0.349 1.0 1.0 GNG2 -0.009 0.137 -9999.0 0.0 -0.772 1.0 1.0 TRIP6 0.003 0.092 -9999.0 0.0 -0.502 1.0 1.0 GNAO1 -0.001 0.079 -9999.0 0.0 -0.304 1.0 1.0 HRAS 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKBIA 0.004 0.083 -9999.0 0.0 -9999.0 0.0 0.0 GAB1 -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 lamellipodium assembly -0.0 0.033 -9999.0 0.0 -9999.0 0.0 0.0 JUN -0.058 0.23 -9999.0 0.0 -0.774 3.0 3.0 LPA/LPA2/NHERF2 -0.024 0.092 -9999.0 0.0 -0.517 1.0 1.0 TIAM1 -0.002 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.008 0.137 -9999.0 0.0 -0.771 1.0 1.0 mol:IP3 -0.011 0.097 -9999.0 0.0 -0.411 1.0 1.0 PLCB3 0.002 0.088 -9999.0 0.0 -0.466 1.0 1.0 FOS -0.076 0.218 -9999.0 0.0 -0.576 5.0 5.0 positive regulation of mitosis 0.012 0.1 -9999.0 0.0 -0.349 1.0 1.0 LPA/LPA1-2-3 -0.021 0.068 -9999.0 0.0 -0.229 3.0 3.0 mol:Ca ++ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JNK cascade -0.0 0.001 -9999.0 0.0 -9999.0 0.0 0.0 BCAR1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 stress fiber formation 0.007 0.058 -9999.0 0.0 -0.2 1.0 1.0 GNAZ -0.001 0.079 -9999.0 0.0 -0.304 1.0 1.0 EGFR/PI3K-beta/Gab1 -0.14 0.218 -9999.0 0.0 -0.495 7.0 7.0 positive regulation of dendritic cell cytokine production -0.021 0.067 -9999.0 0.0 -0.228 3.0 3.0 LPA/LPA2/MAGI-3 -0.05 0.142 -9999.0 0.0 -0.475 3.0 3.0 ARHGEF1 0.01 0.099 -9999.0 0.0 -0.436 1.0 1.0 GNAI2 -0.018 0.118 -9999.0 0.0 -0.405 2.0 2.0 GNAI3 -0.001 0.079 -9999.0 0.0 -0.304 1.0 1.0 GNAI1 -0.018 0.118 -9999.0 0.0 -0.407 2.0 2.0 LPA/LPA3 -0.011 0.033 -9999.0 0.0 -0.113 3.0 3.0 LPA/LPA2 -0.011 0.033 -9999.0 0.0 -0.112 3.0 3.0 LPA/LPA1 -0.028 0.089 -9999.0 0.0 -0.302 3.0 3.0 HB-EGF/EGFR -0.158 0.257 -9999.0 0.0 -0.567 7.0 7.0 HBEGF -0.038 0.223 -9999.0 0.0 -0.675 3.0 3.0 mol:DAG -0.011 0.097 -9999.0 0.0 -0.411 1.0 1.0 cAMP biosynthetic process 0.009 0.101 -9999.0 0.0 -0.344 1.0 1.0 NFKB1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNB1 0.016 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LYN 0.004 0.083 -9999.0 0.0 -9999.0 0.0 0.0 GNAQ -0.005 0.026 -9999.0 0.0 -0.085 3.0 3.0 LPAR2 -0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LPAR3 -0.001 0.001 -9999.0 0.0 -9999.0 0.0 0.0 LPAR1 -0.011 0.053 -9999.0 0.0 -0.175 3.0 3.0 IL8 -0.259 0.265 -9999.0 0.0 -0.514 15.0 15.0 PTK2 -0.001 0.066 -9999.0 0.0 -0.256 1.0 1.0 Rac1/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CASP3 -0.002 0.066 -9999.0 0.0 -0.26 1.0 1.0 EGFR -0.176 0.312 -9999.0 0.0 -0.664 9.0 9.0 PLCG1 -0.019 0.073 -9999.0 0.0 -0.197 3.0 3.0 PLD2 -0.001 0.066 -9999.0 0.0 -0.256 1.0 1.0 G12/G13 -0.029 0.097 -9999.0 0.0 -0.472 1.0 1.0 PI3K-beta -0.063 0.169 -9999.0 0.0 -0.57 3.0 3.0 cell migration -0.006 0.033 -9999.0 0.0 -9999.0 0.0 0.0 SLC9A3R2 -0.009 0.137 -9999.0 0.0 -0.774 1.0 1.0 PXN 0.007 0.059 -9999.0 0.0 -0.203 1.0 1.0 HRAS/GTP 0.012 0.102 -9999.0 0.0 -0.357 1.0 1.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MMP9 -0.034 0.191 -9999.0 0.0 -0.774 2.0 2.0 PRKCE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCD -0.002 0.093 -9999.0 0.0 -0.385 1.0 1.0 Gi(beta/gamma) 0.008 0.112 -9999.0 0.0 -0.459 1.0 1.0 mol:LPA -0.012 0.053 -9999.0 0.0 -0.175 3.0 3.0 TRIP6/p130 Cas/FAK1/Paxillin -0.017 0.065 -9999.0 0.0 -9999.0 0.0 0.0 MAPKKK cascade 0.012 0.1 -9999.0 0.0 -0.349 1.0 1.0 contractile ring contraction involved in cytokinesis -0.007 0.108 -9999.0 0.0 -0.504 1.0 1.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA14 -0.043 0.137 -9999.0 0.0 -0.388 4.0 4.0 GNA15 -0.024 0.1 -9999.0 0.0 -0.32 3.0 3.0 GNA12 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA13 -0.001 0.094 -9999.0 0.0 -0.526 1.0 1.0 MAPT 0.003 0.088 -9999.0 0.0 -0.394 1.0 1.0 GNA11 0.005 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.0 0.034 -9999.0 0.0 -9999.0 0.0 0.0 MMP2 -0.037 0.196 -9999.0 0.0 -0.626 3.0 3.0