IL6-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations BCL2L1 -0.181 0.296 -9999.0 0.0 -0.77 1.0 1.0 CRP -0.181 0.296 -9999.0 0.0 -0.77 1.0 1.0 cell cycle arrest -0.22 0.328 -9999.0 0.0 -0.759 3.0 3.0 TIMP1 -0.145 0.287 -9999.0 0.0 -1.054 1.0 1.0 IL6ST -0.023 0.138 -9999.0 0.0 -0.556 2.0 2.0 Rac1/GDP -0.101 0.257 -9999.0 0.0 -0.683 3.0 3.0 AP1 -0.027 0.214 -9999.0 0.0 -0.63 3.0 3.0 GAB2 0.02 0.005 -9999.0 0.0 -9999.0 0.0 0.0 TNFSF11 -0.271 0.403 -9999.0 0.0 -0.881 6.0 6.0 HSP90B1 -0.04 0.26 -9999.0 0.0 -1.418 1.0 1.0 GAB1 -0.007 0.138 -9999.0 0.0 -0.773 1.0 1.0 MAPK14 -0.076 0.294 -9999.0 0.0 -0.855 3.0 3.0 AKT1 0.04 0.135 -9999.0 0.0 -0.65 1.0 1.0 FOXO1 0.047 0.128 -9999.0 0.0 -0.609 1.0 1.0 MAP2K6 -0.094 0.3 -9999.0 0.0 -0.852 3.0 3.0 mol:GTP -0.002 0.004 -9999.0 0.0 -9999.0 0.0 0.0 MAP2K4 -0.118 0.259 -9999.0 0.0 -0.65 3.0 3.0 MITF -0.089 0.268 -9999.0 0.0 -0.739 3.0 3.0 positive regulation of NF-kappaB transcription factor activity 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TYK2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 A2M -0.098 0.309 -9999.0 0.0 -1.497 1.0 1.0 CEBPB 0.009 0.095 -9999.0 0.0 -0.519 1.0 1.0 GRB2/SOS1/GAB family/SHP2 0.007 0.105 -9999.0 0.0 -9999.0 0.0 0.0 STAT3 -0.23 0.341 -9999.0 0.0 -0.809 3.0 3.0 STAT1 -0.039 0.161 -9999.0 0.0 -0.933 1.0 1.0 CEBPD -0.202 0.338 -9999.0 0.0 -0.965 2.0 2.0 PIK3CA 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.008 0.111 -9999.0 0.0 -0.612 1.0 1.0 JUN -0.058 0.23 -9999.0 0.0 -0.773 3.0 3.0 PIAS3/MITF -0.076 0.251 -9999.0 0.0 -0.689 3.0 3.0 MAPK11 -0.076 0.294 -9999.0 0.0 -0.855 3.0 3.0 STAT3 (dimer)/FOXO1 -0.154 0.335 0.498 2.0 -0.935 2.0 4.0 GRB2/SOS1/GAB family -0.089 0.251 -9999.0 0.0 -0.928 2.0 2.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.106 0.315 -9999.0 0.0 -1.19 2.0 2.0 GRB2 0.018 0.005 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LBP -0.139 0.281 -9999.0 0.0 -0.636 3.0 3.0 PIK3R1 -0.008 0.141 -9999.0 0.0 -0.792 1.0 1.0 JAK1 -0.01 0.138 -9999.0 0.0 -0.778 1.0 1.0 MYC -0.181 0.296 -9999.0 0.0 -0.77 1.0 1.0 FGG -0.533 0.552 -9999.0 0.0 -1.05 15.0 15.0 macrophage differentiation -0.22 0.328 -9999.0 0.0 -0.759 3.0 3.0 IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.119 0.216 -9999.0 0.0 -0.648 3.0 3.0 JUNB -0.176 0.287 -9999.0 0.0 -0.742 1.0 1.0 FOS -0.076 0.218 -9999.0 0.0 -0.575 5.0 5.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.104 0.285 0.365 2.0 -0.791 3.0 5.0 STAT1/PIAS1 -0.108 0.256 0.365 2.0 -0.803 2.0 4.0 GRB2/SOS1/GAB family/SHP2/PI3K 0.031 0.106 -9999.0 0.0 -0.47 1.0 1.0 STAT3 (dimer) -0.228 0.337 -9999.0 0.0 -0.795 3.0 3.0 PRKCD -0.137 0.27 -9999.0 0.0 -0.891 1.0 1.0 IL6R -0.035 0.192 -9999.0 0.0 -0.777 2.0 2.0 SOCS3 -0.072 0.328 -9999.0 0.0 -1.14 2.0 2.0 gp130 (dimer)/JAK1/JAK1/LMO4 -0.036 0.155 -9999.0 0.0 -0.467 3.0 3.0 Rac1/GTP -0.115 0.261 -9999.0 0.0 -0.693 3.0 3.0 HCK -0.008 0.137 -9999.0 0.0 -0.773 1.0 1.0 MAPKKK cascade 0.026 0.11 -9999.0 0.0 -9999.0 0.0 0.0 bone resorption -0.253 0.379 -9999.0 0.0 -0.816 6.0 6.0 IRF1 -0.181 0.296 -9999.0 0.0 -0.77 1.0 1.0 mol:GDP -0.107 0.269 0.342 2.0 -0.649 4.0 6.0 SOS1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VAV1 -0.109 0.276 0.343 2.0 -0.664 4.0 6.0 IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.078 0.305 -9999.0 0.0 -0.887 3.0 3.0 PTPN11 -0.009 0.017 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA -0.123 0.241 -9999.0 0.0 -0.496 8.0 8.0 gp130 (dimer)/TYK2/TYK2/LMO4 -0.022 0.124 -9999.0 0.0 -0.429 2.0 2.0 gp130 (dimer)/JAK2/JAK2/LMO4 -0.022 0.124 -9999.0 0.0 -0.429 2.0 2.0 IL6 -0.132 0.251 -9999.0 0.0 -0.56 8.0 8.0 PIAS3 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTPRE -0.075 0.265 -9999.0 0.0 -0.776 4.0 4.0 PIAS1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.015 0.002 -9999.0 0.0 -9999.0 0.0 0.0 IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.053 0.177 0.318 2.0 -0.401 3.0 5.0 LMO4 -0.013 0.136 -9999.0 0.0 -0.768 1.0 1.0 STAT3 (dimer)/PIAS3 -0.245 0.292 0.456 2.0 -0.764 3.0 5.0 MCL1 0.027 0.24 -9999.0 0.0 -1.281 1.0 1.0