Nectin adhesion pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 alphaV beta3 Integrin -0.01 0.127 -9999.0 0.0 -0.418 13.0 13.0 PTK2 -0.15 0.223 -9999.0 0.0 -0.507 37.0 37.0 positive regulation of JNK cascade -0.082 0.129 -9999.0 0.0 -0.321 33.0 33.0 CDC42/GDP -0.071 0.209 -9999.0 0.0 -0.442 33.0 33.0 Rac1/GDP -0.069 0.208 -9999.0 0.0 -0.436 33.0 33.0 RAP1B 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 RAP1A 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 CTNNB1 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 CDC42/GTP -0.099 0.161 -9999.0 0.0 -0.395 33.0 33.0 nectin-3/I-afadin -0.117 0.22 -9999.0 0.0 -0.436 48.0 48.0 RAPGEF1 -0.082 0.227 -9999.0 0.0 -0.49 33.0 33.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.106 0.258 -9999.0 0.0 -0.57 33.0 33.0 PDGFB-D/PDGFRB 0.015 0.038 -9999.0 0.0 -0.457 1.0 1.0 TLN1 -0.033 0.124 -9999.0 0.0 -0.579 3.0 3.0 Rap1/GTP -0.089 0.141 -9999.0 0.0 -0.344 33.0 33.0 IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.028 0.051 -9999.0 0.0 -0.379 2.0 2.0 nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin -0.117 0.22 -9999.0 0.0 -0.436 48.0 48.0 PVR 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 Necl-5(dimer) 0.006 0.086 -9999.0 0.0 -0.597 3.0 3.0 mol:GDP -0.1 0.254 -9999.0 0.0 -0.552 33.0 33.0 MLLT4 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA -0.003 0.107 -9999.0 0.0 -0.528 6.0 6.0 PI3K -0.097 0.191 -9999.0 0.0 -0.369 41.0 41.0 nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin -0.02 0.149 -9999.0 0.0 -0.492 14.0 14.0 positive regulation of lamellipodium assembly -0.102 0.146 -9999.0 0.0 -0.349 35.0 35.0 PVRL1 -0.044 0.197 -9999.0 0.0 -0.668 14.0 14.0 PVRL3 -0.175 0.292 -9999.0 0.0 -0.602 48.0 48.0 PVRL2 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 PIK3R1 -0.038 0.168 -9999.0 0.0 -0.523 16.0 16.0 CDH1 -0.019 0.151 -9999.0 0.0 -0.621 9.0 9.0 CLDN1 -0.196 0.298 -9999.0 0.0 -0.594 54.0 54.0 JAM-A/CLDN1 -0.208 0.275 -9999.0 0.0 -0.479 64.0 64.0 SRC -0.129 0.286 -9999.0 0.0 -0.644 33.0 33.0 ITGB3 -0.005 0.107 -9999.0 0.0 -0.488 7.0 7.0 nectin-1(dimer)/I-afadin/I-afadin -0.02 0.149 -9999.0 0.0 -0.492 14.0 14.0 FARP2 -0.092 0.243 -9999.0 0.0 -0.531 33.0 33.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) -0.095 0.202 -9999.0 0.0 -0.433 34.0 34.0 nectin-1/I-afadin -0.02 0.149 -9999.0 0.0 -0.492 14.0 14.0 nectin-2/I-afadin 0.019 0.057 -9999.0 0.0 -0.373 3.0 3.0 RAC1/GTP/IQGAP1/filamentous actin 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin -0.126 0.234 -9999.0 0.0 -0.467 42.0 42.0 CDC42/GTP/IQGAP1/filamentous actin 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 F11R -0.013 0.137 -9999.0 0.0 -0.589 8.0 8.0 positive regulation of filopodium formation -0.082 0.129 -9999.0 0.0 -0.321 33.0 33.0 alphaV/beta3 Integrin/Talin -0.036 0.147 -9999.0 0.0 -0.547 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.057 -9999.0 0.0 -0.373 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin 0.019 0.057 -9999.0 0.0 -0.373 3.0 3.0 PIP5K1C -0.042 0.128 -9999.0 0.0 -0.707 2.0 2.0 VAV2 -0.13 0.279 -9999.0 0.0 -0.566 40.0 40.0 RAP1/GDP -0.104 0.169 -9999.0 0.0 -0.408 33.0 33.0 ITGAV -0.01 0.132 -9999.0 0.0 -0.608 7.0 7.0 nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin -0.094 0.196 -9999.0 0.0 -0.422 34.0 34.0 nectin-3(dimer)/I-afadin/I-afadin -0.117 0.22 -9999.0 0.0 -0.436 48.0 48.0 Rac1/GTP -0.123 0.182 -9999.0 0.0 -0.429 35.0 35.0 PTPRM -0.052 0.13 -9999.0 0.0 -0.26 33.0 33.0 E-cadherin/beta catenin/alpha catenin -0.055 0.126 -9999.0 0.0 -0.604 2.0 2.0 adherens junction assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0