IL12-mediated signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations IL12/IL12R/TYK2/JAK2/SOCS1 -0.049 0.205 -9999.0 0.0 -0.465 20.0 20.0 TBX21 -0.239 0.593 -9999.0 0.0 -1.326 31.0 31.0 B2M -0.008 0.133 -9999.0 0.0 -0.667 6.0 6.0 TYK2 0.012 0.07 -9999.0 0.0 -0.466 3.0 3.0 IL12RB1 0.021 0.019 -9999.0 0.0 -9999.0 0.0 0.0 GADD45B -0.147 0.441 -9999.0 0.0 -1.044 23.0 23.0 IL12RB2 -0.143 0.273 -9999.0 0.0 -0.563 44.0 44.0 GADD45G -0.16 0.449 -9999.0 0.0 -1.053 24.0 24.0 natural killer cell activation 0.005 0.022 -9999.0 0.0 -9999.0 0.0 0.0 RELB -0.004 0.114 -9999.0 0.0 -0.563 6.0 6.0 RELA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18 -0.058 0.216 -9999.0 0.0 -0.627 19.0 19.0 IL2RA -0.038 0.187 -9999.0 0.0 -0.652 13.0 13.0 IFNG -0.213 0.297 -9999.0 0.0 -0.577 60.0 60.0 STAT3 (dimer) -0.106 0.38 -9999.0 0.0 -0.883 23.0 23.0 HLA-DRB5 -0.03 0.168 -9999.0 0.0 -0.63 11.0 11.0 FASLG -0.214 0.556 -9999.0 0.0 -1.337 25.0 25.0 NF kappa B2 p52/RelB -0.237 0.433 -9999.0 0.0 -0.99 31.0 31.0 CD4 0.013 0.039 -9999.0 0.0 -0.457 1.0 1.0 SOCS1 0.005 0.085 -9999.0 0.0 -0.51 4.0 4.0 EntrezGene:6955 -0.003 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CD3D -0.042 0.187 -9999.0 0.0 -0.627 14.0 14.0 CD3E 0.016 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CD3G -0.112 0.262 -9999.0 0.0 -0.641 30.0 30.0 IL12Rbeta2/JAK2 -0.102 0.224 -9999.0 0.0 -0.438 41.0 41.0 CCL3 -0.163 0.479 -9999.0 0.0 -1.158 23.0 23.0 CCL4 -0.166 0.486 -9999.0 0.0 -1.127 25.0 25.0 HLA-A -0.002 0.116 -9999.0 0.0 -0.629 5.0 5.0 IL18/IL18R -0.091 0.275 -9999.0 0.0 -0.503 37.0 37.0 NOS2 -0.162 0.461 -9999.0 0.0 -0.983 29.0 29.0 IL12/IL12R/TYK2/JAK2/SPHK2 -0.044 0.191 -9999.0 0.0 -0.436 18.0 18.0 IL1R1 -0.192 0.525 -9999.0 0.0 -1.185 28.0 28.0 IL4 0.016 0.02 -9999.0 0.0 -9999.0 0.0 0.0 JAK2 0.003 0.107 -9999.0 0.0 -0.562 5.0 5.0 EntrezGene:6957 -0.002 0.011 -9999.0 0.0 -9999.0 0.0 0.0 TCR/CD3/MHC I/CD8 -0.128 0.393 -9999.0 0.0 -0.874 25.0 25.0 RAB7A -0.102 0.367 -9999.0 0.0 -0.83 23.0 23.0 lysosomal transport -0.092 0.346 -9999.0 0.0 -0.774 23.0 23.0 FOS -0.258 0.529 -9999.0 0.0 -1.171 33.0 33.0 STAT4 (dimer) -0.145 0.453 -9999.0 0.0 -0.974 28.0 28.0 STAT5A (dimer) -0.297 0.462 -9999.0 0.0 -0.993 37.0 37.0 GZMA -0.164 0.459 -9999.0 0.0 -0.971 30.0 30.0 GZMB -0.167 0.495 -9999.0 0.0 -1.199 23.0 23.0 HLX 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 LCK -0.212 0.548 -9999.0 0.0 -1.144 31.0 31.0 TCR/CD3/MHC II/CD4 -0.141 0.389 -9999.0 0.0 -0.88 25.0 25.0 IL2/IL2R -0.022 0.17 -9999.0 0.0 -0.47 15.0 15.0 MAPK14 -0.15 0.459 -9999.0 0.0 -1.016 26.0 26.0 CCR5 -0.185 0.519 -9999.0 0.0 -1.347 21.0 21.0 IL1B -0.139 0.282 -9999.0 0.0 -0.613 39.0 39.0 STAT6 -0.038 0.174 -9999.0 0.0 -0.367 17.0 17.0 STAT4 -0.016 0.141 -9999.0 0.0 -0.574 9.0 9.0 STAT3 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 STAT1 -0.019 0.151 -9999.0 0.0 -0.621 9.0 9.0 NFKB1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NFKB2 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 IL12B 0.005 0.111 -9999.0 0.0 -0.582 5.0 5.0 CD8A 0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CD8B -0.018 0.134 -9999.0 0.0 -0.494 11.0 11.0 T-helper 1 cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 natural killer cell mediated cytotoxicity 0.049 0.203 0.46 20.0 -9999.0 0.0 20.0 IL2RB -0.013 0.137 -9999.0 0.0 -0.589 8.0 8.0 proteasomal ubiquitin-dependent protein catabolic process -0.121 0.401 -9999.0 0.0 -0.853 28.0 28.0 IL2RG -0.012 0.124 -9999.0 0.0 -0.504 9.0 9.0 IL12 0.003 0.121 -9999.0 0.0 -0.39 12.0 12.0 STAT5A 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 CD247 -0.09 0.24 -9999.0 0.0 -0.616 26.0 26.0 IL2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SPHK2 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 FRAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL12A -0.003 0.117 -9999.0 0.0 -0.524 7.0 7.0 IL12/IL12R/TYK2/JAK2 -0.237 0.658 -9999.0 0.0 -1.32 30.0 30.0 MAP2K3 -0.155 0.463 -9999.0 0.0 -1.013 27.0 27.0 RIPK2 0.005 0.085 -9999.0 0.0 -0.51 4.0 4.0 MAP2K6 -0.16 0.461 -9999.0 0.0 -1.028 26.0 26.0 regulation of dendritic cell antigen processing and presentation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HLA-DRA -0.029 0.169 -9999.0 0.0 -0.668 10.0 10.0 IL18RAP -0.096 0.251 -9999.0 0.0 -0.608 29.0 29.0 IL12Rbeta1/TYK2 0.023 0.058 -9999.0 0.0 -0.324 3.0 3.0 EOMES -0.045 0.264 -9999.0 0.0 -1.415 5.0 5.0 STAT1 (dimer) -0.212 0.42 -9999.0 0.0 -0.926 31.0 31.0 T cell proliferation -0.086 0.319 -9999.0 0.0 -0.641 30.0 30.0 T-helper 1 cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IL18R1 -0.026 0.165 -9999.0 0.0 -0.583 12.0 12.0 CD8-positive alpha-beta T cell lineage commitment -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NF kappa B1 p50/RelA -0.2 0.298 -9999.0 0.0 -0.721 33.0 33.0 ATF2 -0.123 0.408 -9999.0 0.0 -0.893 26.0 26.0