Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) -0.031 0.115 -9999.0 0.0 -0.591 5.0 5.0 HDAC1 0.016 0.038 -9999.0 0.0 -0.414 1.0 1.0 AES 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 0.011 0.067 -9999.0 0.0 -0.563 2.0 2.0 LRP6/FZD1 0.014 0.081 -9999.0 0.0 -0.473 4.0 4.0 TLE1 0.002 0.1 -9999.0 0.0 -0.602 4.0 4.0 AP1 -0.047 0.148 -9999.0 0.0 -0.363 20.0 20.0 NCSTN 0.015 0.038 -9999.0 0.0 -0.457 1.0 1.0 ADAM10 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.0 0.115 -9999.0 0.0 -0.47 3.0 3.0 NICD/RBPSUH 0.019 0.113 -9999.0 0.0 -0.633 4.0 4.0 WIF1 -0.169 0.273 -9999.0 0.0 -0.548 51.0 51.0 NOTCH1 -0.025 0.11 -9999.0 0.0 -0.675 4.0 4.0 PSENEN 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 KREMEN2 -0.232 0.294 -9999.0 0.0 -0.558 67.0 67.0 DKK1 -0.232 0.294 -9999.0 0.0 -0.558 67.0 67.0 beta catenin/beta TrCP1 0.017 0.062 -9999.0 0.0 -0.385 1.0 1.0 APH1B 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 APH1A -0.01 0.132 -9999.0 0.0 -0.608 7.0 7.0 AXIN1 -0.0 0.051 -9999.0 0.0 -0.253 2.0 2.0 CtBP/CBP/TCF1/TLE1/AES 0.035 0.073 0.297 1.0 -9999.0 0.0 1.0 PSEN1 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 FOS -0.107 0.241 -9999.0 0.0 -0.55 34.0 34.0 JUN -0.034 0.17 -9999.0 0.0 -0.563 14.0 14.0 MAP3K7 0.016 0.039 -9999.0 0.0 -0.461 1.0 1.0 CTNNB1 0.006 0.065 -9999.0 0.0 -0.35 2.0 2.0 MAPK3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 -0.158 0.209 -9999.0 0.0 -0.449 38.0 38.0 HNF1A -0.003 0.1 -9999.0 0.0 -0.458 7.0 7.0 CTBP1 0.016 0.035 -9999.0 0.0 -0.41 1.0 1.0 MYC -0.038 0.3 -9999.0 0.0 -1.521 6.0 6.0 NKD1 -0.006 0.105 -9999.0 0.0 -0.455 8.0 8.0 FZD1 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 NOTCH1 precursor/Deltex homolog 1 0.015 0.125 -9999.0 0.0 -0.687 4.0 4.0 apoptosis -0.046 0.148 -9999.0 0.0 -0.361 20.0 20.0 Delta 1/NOTCHprecursor 0.009 0.126 -9999.0 0.0 -0.59 5.0 5.0 DLL1 -0.001 0.108 -9999.0 0.0 -0.584 5.0 5.0 PPARD 0.018 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Gamma Secretase 0.03 0.104 -9999.0 0.0 -0.636 2.0 2.0 APC 0.001 0.049 -9999.0 0.0 -0.257 1.0 1.0 DVL1 0.007 0.063 -9999.0 0.0 -0.546 1.0 1.0 CSNK2A1 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 0.019 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DKK1/LRP6/Kremen 2 -0.277 0.262 -9999.0 0.0 -0.53 67.0 67.0 LRP6 0.011 0.067 -9999.0 0.0 -0.563 2.0 2.0 CSNK1A1 0.014 0.055 -9999.0 0.0 -0.667 1.0 1.0 NLK 0.034 0.025 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 -0.133 0.419 -9999.0 0.0 -1.418 13.0 13.0 WNT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Axin1/APC/beta catenin 0.021 0.074 0.271 1.0 -0.364 1.0 2.0 DKK2 -0.033 0.16 -9999.0 0.0 -0.514 15.0 15.0 NOTCH1 precursor/DVL1 -0.018 0.106 -9999.0 0.0 -0.564 5.0 5.0 GSK3B 0.008 0.077 -9999.0 0.0 -0.528 3.0 3.0 FRAT1 0.015 0.038 -9999.0 0.0 -0.459 1.0 1.0 NOTCH/Deltex homolog 1 -0.025 0.115 -9999.0 0.0 -0.688 4.0 4.0 PPP2R5D 0.001 0.06 0.225 5.0 -0.433 1.0 6.0 MAPK1 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 WNT1/LRP6/FZD1 -0.073 0.174 -9999.0 0.0 -0.385 26.0 26.0 RBPJ 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.019 0.009 -9999.0 0.0 -9999.0 0.0 0.0