ErbB4 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ErbB4/ErbB4/HBEGF/HBEGF -0.025 0.186 -9999.0 0.0 -0.492 17.0 17.0 epithelial cell differentiation -0.067 0.139 -9999.0 0.0 -0.518 8.0 8.0 ITCH 0.019 0.015 -9999.0 0.0 -9999.0 0.0 0.0 WWP1 0.016 0.183 -9999.0 0.0 -1.484 2.0 2.0 FYN 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 EGFR -0.093 0.24 -9999.0 0.0 -0.593 28.0 28.0 PRL 0.009 0.066 -9999.0 0.0 -0.458 3.0 3.0 neuron projection morphogenesis 0.025 0.145 -9999.0 0.0 -0.639 3.0 3.0 PTPRZ1 -0.147 0.29 -9999.0 0.0 -0.651 38.0 38.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC 0.01 0.147 -9999.0 0.0 -0.559 4.0 4.0 ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta -0.02 0.16 -9999.0 0.0 -0.42 16.0 16.0 ADAM17 0.008 0.082 -9999.0 0.0 -0.562 3.0 3.0 ErbB4/ErbB4 0.025 0.116 -9999.0 0.0 -0.583 4.0 4.0 ErbB4/ErbB4/neuregulin 3/neuregulin 3 0.017 0.12 -9999.0 0.0 -0.536 5.0 5.0 NCOR1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.016 0.176 -9999.0 0.0 -0.637 6.0 6.0 GRIN2B -0.011 0.171 -9999.0 0.0 -0.641 5.0 5.0 ErbB4/ErbB2/betacellulin -0.024 0.168 -9999.0 0.0 -0.629 5.0 5.0 STAT1 -0.019 0.151 -9999.0 0.0 -0.621 9.0 9.0 HBEGF -0.068 0.221 -9999.0 0.0 -0.618 21.0 21.0 PRLR -0.017 0.129 -9999.0 0.0 -0.477 11.0 11.0 E4ICDs/ETO2 0.0 0.133 -9999.0 0.0 -0.538 5.0 5.0 axon guidance 0.027 0.13 -9999.0 0.0 -0.713 2.0 2.0 NEDD4 0.006 0.087 -9999.0 0.0 -0.595 3.0 3.0 Prolactin receptor/Prolactin receptor/Prolactin -0.005 0.103 -9999.0 0.0 -0.327 14.0 14.0 CBFA2T3 -0.028 0.147 -9999.0 0.0 -0.488 14.0 14.0 ErbB4/ErbB2/HBEGF -0.021 0.188 -9999.0 0.0 -0.564 11.0 11.0 MAPK3 0.018 0.14 -9999.0 0.0 -0.564 3.0 3.0 STAT1 (dimer) 0.005 0.152 -9999.0 0.0 -0.54 8.0 8.0 MAPK1 0.016 0.15 -9999.0 0.0 -0.67 3.0 3.0 JAK2 0.0 0.101 -9999.0 0.0 -0.542 5.0 5.0 ErbB4/ErbB2/neuregulin 1 beta -0.02 0.176 -9999.0 0.0 -0.677 6.0 6.0 NRG1 -0.041 0.169 -9999.0 0.0 -0.425 24.0 24.0 NRG3 0.002 0.102 -9999.0 0.0 -0.615 4.0 4.0 NRG2 0.003 0.084 -9999.0 0.0 -0.458 5.0 5.0 NRG4 -0.109 0.24 -9999.0 0.0 -0.542 35.0 35.0 heart development 0.027 0.13 -9999.0 0.0 -0.713 2.0 2.0 neural crest cell migration -0.019 0.174 -9999.0 0.0 -0.667 6.0 6.0 ERBB2 0.009 0.106 -9999.0 0.0 -0.434 7.0 7.0 WWOX/E4ICDs 0.027 0.105 -9999.0 0.0 -0.771 2.0 2.0 SHC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/EGFR/neuregulin 4 -0.096 0.222 -9999.0 0.0 -0.613 13.0 13.0 apoptosis 0.032 0.101 0.494 5.0 -9999.0 0.0 5.0 ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta 0.018 0.116 -9999.0 0.0 -0.643 3.0 3.0 ErbB4/ErbB2/epiregulin -0.03 0.16 -9999.0 0.0 -0.594 6.0 6.0 ErbB4/ErbB4/betacellulin/betacellulin -0.029 0.164 -9999.0 0.0 -0.429 16.0 16.0 ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.023 0.199 -9999.0 0.0 -0.537 13.0 13.0 MDM2 0.024 0.114 -9999.0 0.0 -0.641 3.0 3.0 ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta -0.016 0.149 -9999.0 0.0 -0.533 4.0 4.0 STAT5A 0.032 0.123 -9999.0 0.0 -0.676 2.0 2.0 ErbB4/EGFR/neuregulin 1 beta -0.069 0.231 -9999.0 0.0 -0.647 15.0 15.0 DLG4 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 GRB2/SHC 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E4ICDs/TAB2/NCoR1 0.036 0.099 -9999.0 0.0 -0.722 2.0 2.0 STAT5A (dimer) -0.072 0.152 -9999.0 0.0 -0.569 8.0 8.0 MAP3K7IP2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STAT5B (dimer) 0.032 0.121 -9999.0 0.0 -0.676 2.0 2.0 LRIG1 -0.05 0.203 -9999.0 0.0 -0.641 16.0 16.0 EREG -0.089 0.208 -9999.0 0.0 -0.483 33.0 33.0 BTC -0.074 0.218 -9999.0 0.0 -0.571 24.0 24.0 ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta 0.027 0.131 -9999.0 0.0 -0.722 2.0 2.0 ERBB4 0.025 0.117 -9999.0 0.0 -0.586 4.0 4.0 STAT5B 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 YAP1 -0.025 0.118 -9999.0 0.0 -0.714 4.0 4.0 GRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ErbB4/ErbB2/neuregulin 4 -0.042 0.18 -9999.0 0.0 -0.654 6.0 6.0 glial cell differentiation -0.036 0.098 0.712 2.0 -9999.0 0.0 2.0 WWOX 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell proliferation -0.077 0.226 -9999.0 0.0 -0.626 14.0 14.0