Regulation of Telomerase Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Telomerase catalytic core complex -0.072 0.246 -9999.0 0.0 -0.767 11.0 11.0 RAD9A 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AP1 -0.101 0.231 -9999.0 0.0 -0.465 40.0 40.0 IFNAR2 0.006 0.086 -9999.0 0.0 -0.596 3.0 3.0 AKT1 -0.002 0.094 -9999.0 0.0 -0.35 7.0 7.0 ER alpha/Oestrogen -0.037 0.137 -9999.0 0.0 -0.391 19.0 19.0 NFX1/SIN3/HDAC complex 0.05 0.047 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.126 0.249 -9999.0 0.0 -0.536 40.0 40.0 SMG5 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SMG6 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SP3/HDAC2 0.025 0.031 -9999.0 0.0 -0.33 1.0 1.0 TERT/c-Abl -0.057 0.228 -9999.0 0.0 -0.731 10.0 10.0 SAP18 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 MRN complex 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WT1 -0.068 0.21 -9999.0 0.0 -0.558 23.0 23.0 WRN 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 SP1 0.01 0.079 -9999.0 0.0 -0.677 2.0 2.0 SP3 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0 TERF2IP 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 Telomerase/Nucleolin -0.081 0.178 -9999.0 0.0 -0.662 9.0 9.0 Mad/Max 0.015 0.064 -9999.0 0.0 -0.36 4.0 4.0 TERT -0.075 0.259 -9999.0 0.0 -0.835 10.0 10.0 CCND1 -0.126 0.374 -9999.0 0.0 -1.112 16.0 16.0 MAX 0.018 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RBBP7 0.009 0.066 -9999.0 0.0 -0.46 3.0 3.0 RBBP4 0.011 0.067 -9999.0 0.0 -0.563 2.0 2.0 TERF2 0.011 0.055 -9999.0 0.0 -0.462 2.0 2.0 PTGES3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SIN3A 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/911 0.032 0.091 -9999.0 0.0 -0.567 3.0 3.0 CDKN1B -0.125 0.223 -9999.0 0.0 -0.449 38.0 38.0 RAD1 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 XRCC5 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 XRCC6 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SAP30 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 TRF2/PARP2 0.023 0.043 -9999.0 0.0 -0.352 2.0 2.0 UBE3A 0.018 0.003 -9999.0 0.0 -9999.0 0.0 0.0 JUN -0.034 0.17 -9999.0 0.0 -0.563 14.0 14.0 E6 -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 HPV-16 E6/E6AP 0.014 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.107 0.241 -9999.0 0.0 -0.55 34.0 34.0 IFN-gamma/IRF1 -0.162 0.254 -9999.0 0.0 -0.524 39.0 39.0 PARP2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BLM 0.002 0.102 -9999.0 0.0 -0.615 4.0 4.0 Telomerase 0.046 0.067 -9999.0 0.0 -9999.0 0.0 0.0 IRF1 -0.022 0.158 -9999.0 0.0 -0.553 12.0 12.0 ESR1 -0.05 0.186 -9999.0 0.0 -0.535 19.0 19.0 KU/TER 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ATM/TRF2 0.021 0.054 -9999.0 0.0 -0.36 3.0 3.0 ubiquitin-dependent protein catabolic process 0.057 0.047 -9999.0 0.0 -9999.0 0.0 0.0 HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex 0.057 0.048 -9999.0 0.0 -9999.0 0.0 0.0 HDAC1 0.015 0.038 -9999.0 0.0 -0.461 1.0 1.0 HDAC2 0.015 0.04 -9999.0 0.0 -0.472 1.0 1.0 ATM -0.001 0.043 -9999.0 0.0 -0.487 1.0 1.0 SMAD3 0.001 0.115 -9999.0 0.0 -0.453 9.0 9.0 ABL1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MXD1 0.004 0.085 -9999.0 0.0 -0.511 4.0 4.0 MRE11A 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HUS1 0.014 0.055 -9999.0 0.0 -0.668 1.0 1.0 RPS6KB1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TERT/NF kappa B1/14-3-3 -0.063 0.208 -9999.0 0.0 -0.713 9.0 9.0 NR2F2 -0.003 0.114 -9999.0 0.0 -0.621 5.0 5.0 MAPK3 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MAPK1 0.026 0.043 -9999.0 0.0 -0.496 1.0 1.0 TGFB1/TGF beta receptor Type II 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NFKB1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HNRNPC 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis -0.001 0.043 -9999.0 0.0 -0.486 1.0 1.0 NBN 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.093 0.24 -9999.0 0.0 -0.593 28.0 28.0 mol:Oestrogen -0.0 0.002 -9999.0 0.0 -9999.0 0.0 0.0 EGF/EGFR -0.156 0.262 -9999.0 0.0 -0.557 36.0 36.0 MYC -0.009 0.133 -9999.0 0.0 -0.671 6.0 6.0 IL2 0.019 0.009 -9999.0 0.0 -9999.0 0.0 0.0 KU 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAD50 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HSP90AA1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TGFB1 0.018 0.002 -9999.0 0.0 -9999.0 0.0 0.0 TRF2/BLM 0.011 0.083 -9999.0 0.0 -0.394 6.0 6.0 FRAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KU/TERT -0.049 0.229 -9999.0 0.0 -0.725 10.0 10.0 SP1/HDAC2 0.021 0.069 -9999.0 0.0 -0.449 3.0 3.0 PINX1 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 Telomerase/EST1A -0.081 0.178 -9999.0 0.0 -0.662 9.0 9.0 Smad3/Myc -0.005 0.143 -9999.0 0.0 -0.486 11.0 11.0 911 complex 0.029 0.062 -9999.0 0.0 -0.415 3.0 3.0 IFNG -0.206 0.295 -9999.0 0.0 -0.566 60.0 60.0 Telomerase/PinX1 -0.084 0.18 -9999.0 0.0 -0.662 9.0 9.0 Telomerase/AKT1/mTOR/p70S6K 0.03 0.069 -9999.0 0.0 -9999.0 0.0 0.0 SIN3B 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 YWHAE 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Telomerase/EST1B -0.081 0.178 -9999.0 0.0 -0.662 9.0 9.0 response to DNA damage stimulus 0.004 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MRN complex/TRF2/Rap1 0.048 0.039 -9999.0 0.0 -9999.0 0.0 0.0 TRF2/WRN 0.019 0.058 -9999.0 0.0 -0.388 3.0 3.0 Telomerase/hnRNP C1/C2 -0.081 0.178 -9999.0 0.0 -0.662 9.0 9.0 E2F1 0.018 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ZNFX1 0.014 0.055 -9999.0 0.0 -0.67 1.0 1.0 PIF1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCL 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DKC1 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 telomeric DNA binding 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0