Endothelins Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations AKT1 -0.062 0.302 -9999.0 0.0 -0.756 15.0 15.0 PTK2B 0.012 0.054 -9999.0 0.0 -0.457 2.0 2.0 mol:Ca2+ -0.101 0.318 -9999.0 0.0 -0.776 19.0 19.0 EDN1 -0.087 0.305 -9999.0 0.0 -0.621 33.0 33.0 EDN3 -0.043 0.165 -9999.0 0.0 -0.48 19.0 19.0 EDN2 -0.298 0.303 -9999.0 0.0 -0.569 83.0 83.0 HRAS/GDP -0.066 0.238 -9999.0 0.0 -0.608 15.0 15.0 ETA receptor/Endothelin-1/Gq/GTP/PLC beta -0.057 0.212 -9999.0 0.0 -0.466 20.0 20.0 ADCY4 -0.084 0.256 -9999.0 0.0 -0.633 19.0 19.0 ADCY5 -0.086 0.248 -9999.0 0.0 -0.619 19.0 19.0 ADCY6 -0.076 0.247 -9999.0 0.0 -0.629 17.0 17.0 ADCY7 -0.08 0.253 -9999.0 0.0 -0.649 17.0 17.0 ADCY1 -0.076 0.247 -9999.0 0.0 -0.629 17.0 17.0 ADCY2 -0.112 0.258 -9999.0 0.0 -0.608 22.0 22.0 ADCY3 -0.084 0.257 -9999.0 0.0 -0.638 19.0 19.0 ADCY8 -0.126 0.261 -9999.0 0.0 -0.608 24.0 24.0 ADCY9 -0.081 0.249 -9999.0 0.0 -0.604 19.0 19.0 arachidonic acid secretion -0.123 0.271 -9999.0 0.0 -0.546 32.0 32.0 ETB receptor/Endothelin-1/Gq/GTP -0.082 0.207 -9999.0 0.0 -0.434 25.0 25.0 GNAO1 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 HRAS 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 ETA receptor/Endothelin-1/G12/GTP -0.043 0.3 0.335 35.0 -0.691 15.0 50.0 ETA receptor/Endothelin-1/Gs/GTP -0.072 0.29 0.321 26.0 -0.653 18.0 44.0 mol:GTP -0.002 0.008 -9999.0 0.0 -9999.0 0.0 0.0 COL3A1 -0.095 0.372 -9999.0 0.0 -0.887 21.0 21.0 EDNRB -0.029 0.149 -9999.0 0.0 -0.546 11.0 11.0 response to oxidative stress -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYSLTR2 -0.055 0.291 -9999.0 0.0 -0.745 14.0 14.0 CYSLTR1 -0.062 0.315 -9999.0 0.0 -0.829 14.0 14.0 SLC9A1 -0.03 0.153 0.213 17.0 -0.347 14.0 31.0 mol:GDP -0.073 0.244 -9999.0 0.0 -0.553 20.0 20.0 SLC9A3 -0.12 0.341 -9999.0 0.0 -0.701 32.0 32.0 RAF1 -0.081 0.236 -9999.0 0.0 -0.564 18.0 18.0 JUN -0.098 0.337 -9999.0 0.0 -0.934 15.0 15.0 JAK2 -0.067 0.295 -9999.0 0.0 -0.759 15.0 15.0 mol:IP3 -0.068 0.211 -9999.0 0.0 -0.53 16.0 16.0 ETA receptor/Endothelin-1 -0.068 0.363 0.4 33.0 -0.672 25.0 58.0 PLCB1 -0.011 0.132 -9999.0 0.0 -0.61 7.0 7.0 PLCB2 0.013 0.038 -9999.0 0.0 -0.457 1.0 1.0 ETA receptor/Endothelin-3 -0.041 0.197 -9999.0 0.0 -0.463 18.0 18.0 FOS -0.128 0.347 -9999.0 0.0 -0.847 23.0 23.0 Gai/GDP -0.003 0.115 -9999.0 0.0 -0.459 3.0 3.0 CRK 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca ++ -0.12 0.331 -9999.0 0.0 -0.76 24.0 24.0 BCAR1 0.018 0.001 -9999.0 0.0 -9999.0 0.0 0.0 PRKCB1 -0.082 0.223 -9999.0 0.0 -0.504 23.0 23.0 GNAQ -0.002 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GNAZ -0.022 0.155 -9999.0 0.0 -0.605 10.0 10.0 GNAL -0.035 0.165 -9999.0 0.0 -0.528 15.0 15.0 Gs family/GDP -0.125 0.186 -9999.0 0.0 -0.509 20.0 20.0 ETA receptor/Endothelin-1/Gq/GTP -0.068 0.246 -9999.0 0.0 -0.468 27.0 27.0 MAPK14 -0.057 0.178 -9999.0 0.0 -0.479 14.0 14.0 TRPC6 -0.11 0.341 -9999.0 0.0 -0.877 17.0 17.0 GNAI2 0.009 0.066 -9999.0 0.0 -0.458 3.0 3.0 GNAI3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.032 0.176 -9999.0 0.0 -0.633 12.0 12.0 ETB receptor/Endothelin-1/Gq/GTP/PLC beta -0.068 0.187 -9999.0 0.0 -0.468 17.0 17.0 ETB receptor/Endothelin-2 -0.238 0.243 -9999.0 0.0 -0.426 90.0 90.0 ETB receptor/Endothelin-3 -0.05 0.159 -9999.0 0.0 -0.373 27.0 27.0 ETB receptor/Endothelin-1 -0.094 0.266 -9999.0 0.0 -0.542 32.0 32.0 MAPK3 -0.114 0.315 -9999.0 0.0 -0.742 24.0 24.0 MAPK1 -0.115 0.316 -9999.0 0.0 -0.746 24.0 24.0 Rac1/GDP -0.059 0.227 -9999.0 0.0 -0.538 17.0 17.0 cAMP biosynthetic process -0.08 0.234 -9999.0 0.0 -0.598 17.0 17.0 MAPK8 -0.091 0.308 -9999.0 0.0 -0.699 21.0 21.0 SRC 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 ETB receptor/Endothelin-1/Gi/GTP -0.047 0.179 -9999.0 0.0 -0.438 15.0 15.0 p130Cas/CRK/Src/PYK2 -0.078 0.263 -9999.0 0.0 -0.577 22.0 22.0 mol:K + 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G12/GDP -0.059 0.227 -9999.0 0.0 -0.551 16.0 16.0 COL1A2 -0.147 0.446 -9999.0 0.0 -0.996 26.0 26.0 EntrezGene:2778 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ETA receptor/Endothelin-2 -0.227 0.28 -9999.0 0.0 -0.505 63.0 63.0 mol:DAG -0.069 0.211 -9999.0 0.0 -0.531 16.0 16.0 MAP2K2 -0.093 0.264 -9999.0 0.0 -0.587 25.0 25.0 MAP2K1 -0.093 0.264 -9999.0 0.0 -0.606 23.0 23.0 EDNRA -0.005 0.216 -9999.0 0.0 -0.563 16.0 16.0 positive regulation of muscle contraction -0.048 0.268 -9999.0 0.0 -0.694 14.0 14.0 Gq family/GDP -0.127 0.213 -9999.0 0.0 -0.553 23.0 23.0 HRAS/GTP -0.075 0.221 -9999.0 0.0 -0.544 17.0 17.0 PRKCH -0.07 0.225 -9999.0 0.0 -0.567 17.0 17.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PRKCA -0.063 0.211 -9999.0 0.0 -0.545 15.0 15.0 PRKCB -0.068 0.203 -9999.0 0.0 -0.513 16.0 16.0 PRKCE -0.058 0.202 -9999.0 0.0 -0.533 14.0 14.0 PRKCD -0.063 0.206 -9999.0 0.0 -0.528 15.0 15.0 PRKCG -0.06 0.204 -9999.0 0.0 -0.539 14.0 14.0 regulation of vascular smooth muscle contraction -0.148 0.396 -9999.0 0.0 -1.002 22.0 22.0 PRKCQ -0.083 0.227 -9999.0 0.0 -0.575 17.0 17.0 PLA2G4A -0.137 0.298 -9999.0 0.0 -0.603 32.0 32.0 GNA14 -0.028 0.149 -9999.0 0.0 -0.51 13.0 13.0 GNA15 -0.052 0.202 -9999.0 0.0 -0.643 16.0 16.0 GNA12 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNA11 0.007 0.078 -9999.0 0.0 -0.673 2.0 2.0 Rac1/GTP -0.043 0.299 0.335 35.0 -0.689 15.0 50.0 MMP1 -0.313 0.482 -9999.0 0.0 -0.872 58.0 58.0