Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.175 0.347 -9999.0 0.0 -0.647 44.0 44.0 IHH -0.025 0.111 -9999.0 0.0 -0.596 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.091 0.198 -9999.0 0.0 -0.424 33.0 33.0 LRPAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.09 0.197 0.421 33.0 -9999.0 0.0 33.0 SMO/beta Arrestin2 -0.124 0.27 -9999.0 0.0 -0.713 18.0 18.0 SMO -0.139 0.284 -9999.0 0.0 -0.732 20.0 20.0 AKT1 -0.077 0.219 -9999.0 0.0 -0.896 7.0 7.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.117 -9999.0 0.0 -0.458 10.0 10.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.137 0.279 -9999.0 0.0 -0.716 20.0 20.0 STIL -0.071 0.2 -9999.0 0.0 -0.601 10.0 10.0 DHH N/PTCH2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.061 0.173 -9999.0 0.0 -0.491 4.0 4.0 PIK3CA -0.003 0.107 -9999.0 0.0 -0.528 6.0 6.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.302 0.543 -9999.0 0.0 -1.122 44.0 44.0 determination of left/right symmetry -0.137 0.279 -9999.0 0.0 -0.716 20.0 20.0 PIK3R1 -0.038 0.168 -9999.0 0.0 -0.523 16.0 16.0 skeletal system development -0.296 0.532 -9999.0 0.0 -1.1 44.0 44.0 IHH N/Hhip -0.133 0.227 -9999.0 0.0 -0.448 50.0 50.0 DHH N/Hhip -0.1 0.198 -9999.0 0.0 -0.39 47.0 47.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.137 0.279 -9999.0 0.0 -0.716 20.0 20.0 pancreas development -0.154 0.266 -9999.0 0.0 -0.546 47.0 47.0 HHAT -0.035 0.184 -9999.0 0.0 -0.668 12.0 12.0 PI3K -0.03 0.143 -9999.0 0.0 -0.371 22.0 22.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.135 0.268 -9999.0 0.0 -0.587 39.0 39.0 somite specification -0.137 0.279 -9999.0 0.0 -0.716 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.075 0.2 -9999.0 0.0 -0.623 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.002 0.114 -9999.0 0.0 -0.378 13.0 13.0 SHH Np/Cholesterol/Megalin -0.025 0.144 -9999.0 0.0 -0.428 14.0 14.0 SHH -0.014 0.145 -9999.0 0.0 -0.492 13.0 13.0 catabolic process -0.08 0.195 -9999.0 0.0 -0.456 15.0 15.0 SMO/Vitamin D3 -0.11 0.254 -9999.0 0.0 -0.67 18.0 18.0 SHH Np/Cholesterol/Hhip -0.101 0.188 -9999.0 0.0 -0.411 31.0 31.0 LRP2 -0.023 0.138 -9999.0 0.0 -0.474 13.0 13.0 receptor-mediated endocytosis -0.103 0.245 -9999.0 0.0 -0.644 17.0 17.0 SHH Np/Cholesterol/BOC -0.019 0.127 -9999.0 0.0 -0.378 13.0 13.0 SHH Np/Cholesterol/CDO -0.01 0.126 -9999.0 0.0 -0.396 13.0 13.0 mesenchymal cell differentiation 0.1 0.186 0.408 31.0 -9999.0 0.0 31.0 mol:Vitamin D3 -0.072 0.202 -9999.0 0.0 -0.581 11.0 11.0 IHH N/PTCH2 0.005 0.066 -9999.0 0.0 -0.354 4.0 4.0 CDON 0.003 0.084 -9999.0 0.0 -0.458 5.0 5.0 IHH N/PTCH1 -0.08 0.197 -9999.0 0.0 -0.459 15.0 15.0 Megalin/LRPAP1 -0.003 0.1 -9999.0 0.0 -0.328 13.0 13.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.014 0.114 -9999.0 0.0 -0.389 13.0 13.0 PTCH1 -0.081 0.196 -9999.0 0.0 -0.457 15.0 15.0 HHIP -0.154 0.267 -9999.0 0.0 -0.547 47.0 47.0