Plasma membrane estrogen receptor signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations GNB1/GNG2 0.003 0.105 -9999.0 0.0 -0.349 7.0 7.0 ER alpha/Gai/GDP/Gbeta gamma -0.008 0.133 -9999.0 0.0 -0.394 10.0 10.0 AKT1 -0.038 0.216 -9999.0 0.0 -0.869 8.0 8.0 PIK3CA -0.003 0.107 -9999.0 0.0 -0.528 6.0 6.0 E2/ER alpha (dimer)/PELP1/Src/PI3K -0.04 0.218 -9999.0 0.0 -0.873 8.0 8.0 mol:Ca2+ -0.031 0.15 -9999.0 0.0 -0.413 13.0 13.0 IGF1R -0.043 0.194 -9999.0 0.0 -0.653 14.0 14.0 E2/ER alpha (dimer)/Striatin -0.031 0.133 -9999.0 0.0 -0.331 24.0 24.0 SHC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 apoptosis 0.035 0.204 0.818 8.0 -9999.0 0.0 8.0 RhoA/GTP -0.053 0.107 -9999.0 0.0 -0.443 2.0 2.0 E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.051 0.115 -9999.0 0.0 -0.466 8.0 8.0 regulation of stress fiber formation 0.008 0.132 0.452 4.0 -9999.0 0.0 4.0 E2/ERA-ERB (dimer) -0.022 0.121 -9999.0 0.0 -0.317 21.0 21.0 KRAS -0.003 0.115 -9999.0 0.0 -0.626 5.0 5.0 G13/GTP -0.02 0.113 -9999.0 0.0 -0.295 21.0 21.0 pseudopodium formation -0.008 0.132 -9999.0 0.0 -0.452 4.0 4.0 E2/ER alpha (dimer)/PELP1 -0.018 0.118 -9999.0 0.0 -0.323 19.0 19.0 GRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNG2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAO1 0.015 0.038 -9999.0 0.0 -0.458 1.0 1.0 HRAS 0.006 0.086 -9999.0 0.0 -0.598 3.0 3.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:NO -0.008 0.145 -9999.0 0.0 -0.464 10.0 10.0 E2/ER beta (dimer) 0.009 0.038 -9999.0 0.0 -0.326 2.0 2.0 mol:GDP -0.052 0.112 -9999.0 0.0 -0.424 9.0 9.0 mol:NADP -0.008 0.145 -9999.0 0.0 -0.464 10.0 10.0 PIK3R1 -0.038 0.168 -9999.0 0.0 -0.523 16.0 16.0 mol:IP3 -0.033 0.156 -9999.0 0.0 -0.487 9.0 9.0 IGF-1R heterotetramer -0.043 0.193 -9999.0 0.0 -0.652 14.0 14.0 PLCB1 -0.042 0.157 -9999.0 0.0 -0.427 14.0 14.0 PLCB2 -0.029 0.144 -9999.0 0.0 -0.461 9.0 9.0 IGF1 -0.12 0.256 -9999.0 0.0 -0.574 36.0 36.0 mol:L-citrulline -0.008 0.145 -9999.0 0.0 -0.464 10.0 10.0 RHOA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Gai/GDP 0.002 0.108 -9999.0 0.0 -0.432 3.0 3.0 JNK cascade 0.009 0.038 -9999.0 0.0 -0.325 2.0 2.0 BCAR1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ESR2 0.012 0.054 -9999.0 0.0 -0.458 2.0 2.0 GNAQ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ESR1 -0.05 0.185 -9999.0 0.0 -0.535 19.0 19.0 Gq family/GDP/Gbeta gamma -0.028 0.187 -9999.0 0.0 -0.548 15.0 15.0 E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 0.022 0.079 -9999.0 0.0 -9999.0 0.0 0.0 E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.051 0.115 -9999.0 0.0 -0.466 8.0 8.0 GNAZ -0.022 0.155 -9999.0 0.0 -0.605 10.0 10.0 E2/ER alpha (dimer) -0.036 0.136 -9999.0 0.0 -0.391 19.0 19.0 STRN -0.001 0.108 -9999.0 0.0 -0.584 5.0 5.0 GNAL -0.035 0.165 -9999.0 0.0 -0.528 15.0 15.0 PELP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MAPK11 0.021 0.033 -9999.0 0.0 -0.263 2.0 2.0 GNAI2 0.009 0.066 -9999.0 0.0 -0.458 3.0 3.0 GNAI3 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GNAI1 -0.032 0.176 -9999.0 0.0 -0.633 12.0 12.0 HBEGF -0.048 0.176 -9999.0 0.0 -0.503 13.0 13.0 cAMP biosynthetic process -0.058 0.12 -9999.0 0.0 -0.378 13.0 13.0 SRC 0.001 0.132 -9999.0 0.0 -0.51 3.0 3.0 PI3K -0.03 0.143 -9999.0 0.0 -0.371 22.0 22.0 GNB1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 G13/GDP/Gbeta gamma -0.044 0.097 -9999.0 0.0 -0.384 7.0 7.0 SOS1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.103 0.156 -9999.0 0.0 -0.466 17.0 17.0 Gs family/GTP -0.059 0.122 -9999.0 0.0 -0.384 13.0 13.0 EntrezGene:2778 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAS family/GTP 0.002 0.105 -9999.0 0.0 -0.379 8.0 8.0 vasodilation -0.007 0.14 -9999.0 0.0 -0.444 10.0 10.0 mol:DAG -0.033 0.156 -9999.0 0.0 -0.487 9.0 9.0 Gs family/GDP/Gbeta gamma -0.058 0.113 -9999.0 0.0 -0.392 11.0 11.0 MSN -0.01 0.141 -9999.0 0.0 -0.494 4.0 4.0 Gq family/GTP -0.039 0.15 -9999.0 0.0 -0.358 22.0 22.0 mol:PI-3-4-5-P3 -0.038 0.208 -9999.0 0.0 -0.829 8.0 8.0 NRAS -0.006 0.113 -9999.0 0.0 -0.518 7.0 7.0 mol:E2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cell adhesion 0.007 0.14 0.444 10.0 -9999.0 0.0 10.0 GRB2/SOS1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP -0.047 0.104 -9999.0 0.0 -0.408 8.0 8.0 NOS3 -0.01 0.151 -9999.0 0.0 -0.487 10.0 10.0 GNA11 0.009 0.078 -9999.0 0.0 -0.668 2.0 2.0 MAPKKK cascade 0.004 0.166 -9999.0 0.0 -0.582 9.0 9.0 E2/ER alpha (dimer)/PELP1/Src -0.051 0.125 -9999.0 0.0 -0.493 8.0 8.0 ruffle organization -0.008 0.132 -9999.0 0.0 -0.452 4.0 4.0 ROCK2 -0.001 0.122 -9999.0 0.0 -0.405 2.0 2.0 GNA14 -0.026 0.148 -9999.0 0.0 -0.506 13.0 13.0 GNA15 -0.05 0.203 -9999.0 0.0 -0.641 16.0 16.0 GNA13 0.011 0.067 -9999.0 0.0 -0.563 2.0 2.0 MMP9 -0.023 0.173 -9999.0 0.0 -0.581 7.0 7.0 MMP2 -0.041 0.177 -9999.0 0.0 -0.51 9.0 9.0