Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.132 0.271 -9999.0 0.0 -0.57 36.0 36.0 IHH -0.011 0.089 -9999.0 0.0 -0.548 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.046 0.139 -9999.0 0.0 -0.314 27.0 27.0 LRPAP1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.046 0.138 0.312 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.116 0.227 -9999.0 0.0 -0.526 20.0 20.0 SMO -0.131 0.23 -9999.0 0.0 -0.407 46.0 46.0 AKT1 -0.086 0.195 -9999.0 0.0 -0.637 12.0 12.0 ARRB2 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.021 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.226 -9999.0 0.0 -0.401 46.0 46.0 STIL -0.074 0.144 -9999.0 0.0 -0.278 40.0 40.0 DHH N/PTCH2 0.047 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.053 0.145 -9999.0 0.0 -0.288 36.0 36.0 PIK3CA 0.011 0.048 -9999.0 0.0 -0.518 1.0 1.0 DHH 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.25 0.45 -9999.0 0.0 -0.987 36.0 36.0 determination of left/right symmetry -0.129 0.226 -9999.0 0.0 -0.401 46.0 46.0 PIK3R1 0.004 0.097 -9999.0 0.0 -0.518 4.0 4.0 skeletal system development -0.246 0.443 -9999.0 0.0 -0.972 36.0 36.0 IHH N/Hhip -0.059 0.163 -9999.0 0.0 -0.428 20.0 20.0 DHH N/Hhip -0.031 0.145 -9999.0 0.0 -0.378 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.226 -9999.0 0.0 -0.401 46.0 46.0 pancreas development -0.065 0.187 -9999.0 0.0 -0.517 19.0 19.0 HHAT -0.003 0.137 -9999.0 0.0 -0.518 9.0 9.0 PI3K 0.005 0.067 -9999.0 0.0 -0.378 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.058 0.189 -9999.0 0.0 -0.518 19.0 19.0 somite specification -0.129 0.226 -9999.0 0.0 -0.401 46.0 46.0 SHH Np/Cholesterol/PTCH1 -0.073 0.151 -9999.0 0.0 -0.287 41.0 41.0 SHH Np/Cholesterol/PTCH2 0.008 0.085 -9999.0 0.0 -0.294 10.0 10.0 SHH Np/Cholesterol/Megalin 0.001 0.092 -9999.0 0.0 -0.303 11.0 11.0 SHH -0.013 0.103 -9999.0 0.0 -0.379 10.0 10.0 catabolic process -0.075 0.152 -9999.0 0.0 -0.323 36.0 36.0 SMO/Vitamin D3 -0.108 0.19 -9999.0 0.0 -0.371 37.0 37.0 SHH Np/Cholesterol/Hhip -0.048 0.137 -9999.0 0.0 -0.315 26.0 26.0 LRP2 0.019 0.056 -9999.0 0.0 -0.518 1.0 1.0 receptor-mediated endocytosis -0.104 0.183 -9999.0 0.0 -0.417 23.0 23.0 SHH Np/Cholesterol/BOC -0.001 0.085 -9999.0 0.0 -0.294 10.0 10.0 SHH Np/Cholesterol/CDO 0.006 0.086 -9999.0 0.0 -0.296 10.0 10.0 mesenchymal cell differentiation 0.047 0.136 0.313 26.0 -9999.0 0.0 26.0 mol:Vitamin D3 -0.073 0.151 -9999.0 0.0 -0.287 41.0 41.0 IHH N/PTCH2 0.018 0.06 -9999.0 0.0 -0.334 1.0 1.0 CDON 0.028 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.06 0.162 -9999.0 0.0 -0.325 36.0 36.0 Megalin/LRPAP1 0.032 0.047 -9999.0 0.0 -0.378 1.0 1.0 PTCH2 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.003 0.081 -9999.0 0.0 -0.292 10.0 10.0 PTCH1 -0.075 0.152 -9999.0 0.0 -0.324 36.0 36.0 HHIP -0.065 0.187 -9999.0 0.0 -0.518 19.0 19.0