Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.002 0.072 -9999.0 0.0 -0.262 9.0 9.0 epithelial cell differentiation 0.037 0.088 -9999.0 0.0 -0.276 9.0 9.0 CYFIP2 0.025 0.049 -9999.0 0.0 -0.518 1.0 1.0 ENAH -0.01 0.107 0.268 3.0 -0.336 2.0 5.0 EGFR -0.014 0.144 -9999.0 0.0 -0.518 10.0 10.0 EPHA2 -0.006 0.13 -9999.0 0.0 -0.518 8.0 8.0 MYO6 -0.031 0.073 -9999.0 0.0 -0.267 11.0 11.0 CTNNB1 0.028 0.017 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.045 -9999.0 0.0 -0.324 1.0 1.0 AQP5 -0.077 0.18 -9999.0 0.0 -0.51 18.0 18.0 CTNND1 0.025 0.066 -9999.0 0.0 -0.518 2.0 2.0 mol:PI-4-5-P2 -0.029 0.069 -9999.0 0.0 -0.264 10.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.041 0.089 -9999.0 0.0 -0.281 15.0 15.0 EGF -0.032 0.15 -9999.0 0.0 -0.518 11.0 11.0 NCKAP1 0.028 0.023 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.092 0.173 -9999.0 0.0 -0.458 22.0 22.0 cortical microtubule organization 0.037 0.088 -9999.0 0.0 -0.276 9.0 9.0 GO:0000145 -0.028 0.066 -9999.0 0.0 -0.252 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.043 0.091 -9999.0 0.0 -0.278 9.0 9.0 MLLT4 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.092 -9999.0 0.0 -0.28 17.0 17.0 ARF6 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.023 0.113 -9999.0 0.0 -0.332 10.0 10.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.011 0.052 -9999.0 0.0 -0.263 1.0 1.0 PVRL2 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.03 0.07 -9999.0 0.0 -0.266 10.0 10.0 ARF6/GTP 0.027 0.111 -9999.0 0.0 -0.311 10.0 10.0 CDH1 0.002 0.122 -9999.0 0.0 -0.518 7.0 7.0 EGFR/EGFR/EGF/EGF -0.031 0.139 -9999.0 0.0 -0.298 25.0 25.0 RhoA/GDP 0.039 0.086 -9999.0 0.0 -0.262 9.0 9.0 actin cytoskeleton organization -0.032 0.076 -9999.0 0.0 -0.285 10.0 10.0 IGF-1R heterotetramer -0.01 0.143 -9999.0 0.0 -0.517 10.0 10.0 GIT1 0.024 0.067 -9999.0 0.0 -0.518 2.0 2.0 IGF1R -0.01 0.144 -9999.0 0.0 -0.518 10.0 10.0 IGF1 -0.054 0.185 -9999.0 0.0 -0.518 18.0 18.0 DIAPH1 0.021 0.161 -9999.0 0.0 -0.569 7.0 7.0 Wnt receptor signaling pathway -0.037 0.088 0.276 9.0 -9999.0 0.0 9.0 RHOA 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.091 -9999.0 0.0 -0.279 16.0 16.0 CTNNA1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.033 0.078 -9999.0 0.0 -0.291 10.0 10.0 EFNA1 0.022 0.067 -9999.0 0.0 -0.518 2.0 2.0 LPP -0.02 0.051 -9999.0 0.0 -0.265 5.0 5.0 Ephrin A1/EPHA2 0.006 0.112 -9999.0 0.0 -0.278 16.0 16.0 SEC6/SEC8 -0.029 0.056 -9999.0 0.0 -0.262 7.0 7.0 MGAT3 -0.042 0.091 -9999.0 0.0 -0.286 15.0 15.0 HGF/MET 0.026 0.089 -9999.0 0.0 -0.264 10.0 10.0 HGF 0.029 0.021 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.002 0.073 -9999.0 0.0 -0.264 9.0 9.0 actin cable formation 0.035 0.119 0.275 7.0 -0.273 2.0 9.0 KIAA1543 -0.033 0.071 -9999.0 0.0 -0.264 10.0 10.0 KIFC3 -0.026 0.064 -9999.0 0.0 -0.267 8.0 8.0 NCK1 0.019 0.067 -9999.0 0.0 -0.518 2.0 2.0 EXOC3 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.028 0.068 -9999.0 0.0 -0.271 9.0 9.0 NCK1/GIT1 0.026 0.074 -9999.0 0.0 -0.378 4.0 4.0 mol:GDP 0.037 0.088 -9999.0 0.0 -0.276 9.0 9.0 EXOC4 0.033 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.063 -9999.0 0.0 -0.265 9.0 9.0 PIP5K1C -0.029 0.07 -9999.0 0.0 -0.268 10.0 10.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.01 0.122 0.306 3.0 -0.355 3.0 6.0 adherens junction assembly -0.022 0.104 -9999.0 0.0 -0.571 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.043 0.151 -9999.0 0.0 -0.294 32.0 32.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.044 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.022 0.068 -9999.0 0.0 -0.518 2.0 2.0 PLEKHA7 -0.027 0.067 -9999.0 0.0 -0.267 9.0 9.0 mol:GTP 0.021 0.111 -9999.0 0.0 -0.33 10.0 10.0 establishment of epithelial cell apical/basal polarity -0.002 0.088 0.307 1.0 -0.254 7.0 8.0 cortical actin cytoskeleton stabilization 0.002 0.072 -9999.0 0.0 -0.262 9.0 9.0 regulation of cell-cell adhesion -0.032 0.076 -9999.0 0.0 -0.285 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.002 0.073 -9999.0 0.0 -0.264 9.0 9.0