Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	26.0	2007.0	76.0	-0.282	0.035	1000.0	-1000.0	-0.029	-1000.0
TCGA08_retinoblastoma	23.0	190.0	8.0	-0.071	0.089	1000.0	-1000.0	-0.004	-1000.0
IL23-mediated signaling events	19.0	1148.0	60.0	-0.482	0.032	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by the Hedgehog family	18.0	980.0	52.0	-0.25	0.047	1000.0	-1000.0	-0.031	-1000.0
Osteopontin-mediated events	17.0	654.0	38.0	-0.161	0.033	1000.0	-1000.0	-0.033	-1000.0
IL4-mediated signaling events	17.0	1612.0	91.0	-0.54	0.488	1000.0	-1000.0	-0.097	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	749.0	44.0	-0.169	0.033	1000.0	-1000.0	-0.019	-1000.0
Noncanonical Wnt signaling pathway	16.0	437.0	26.0	-0.124	0.032	1000.0	-1000.0	-0.043	-1000.0
Fc-epsilon receptor I signaling in mast cells	16.0	1606.0	97.0	-0.115	0.043	1000.0	-1000.0	-0.056	-1000.0
Glucocorticoid receptor regulatory network	15.0	1809.0	114.0	-0.451	0.274	1000.0	-1000.0	-0.047	-1000.0
Endothelins	15.0	1490.0	96.0	-0.207	0.032	1000.0	-1000.0	-0.041	-1000.0
Wnt signaling	15.0	106.0	7.0	-0.121	0.029	1000.0	-1000.0	-0.013	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	15.0	1083.0	68.0	-0.389	0.158	1000.0	-1000.0	-0.063	-1000.0
Thromboxane A2 receptor signaling	13.0	1408.0	105.0	-0.163	0.055	1000.0	-1000.0	-0.04	-1000.0
EPHB forward signaling	13.0	1150.0	85.0	-0.104	0.073	1000.0	-1000.0	-0.064	-1000.0
BCR signaling pathway	13.0	1307.0	99.0	-0.201	0.044	1000.0	-1000.0	-0.049	-1000.0
Syndecan-1-mediated signaling events	12.0	431.0	34.0	-0.121	0.037	1000.0	-1000.0	-0.04	-1000.0
Nectin adhesion pathway	12.0	774.0	63.0	-0.103	0.051	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	12.0	606.0	48.0	-0.093	0.041	1000.0	-1000.0	-0.034	-1000.0
IGF1 pathway	12.0	708.0	57.0	-0.072	0.056	1000.0	-1000.0	-0.038	-1000.0
FOXM1 transcription factor network	12.0	644.0	51.0	-0.254	0.041	1000.0	-1000.0	-0.094	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1044.0	93.0	-0.094	0.045	1000.0	-1000.0	-0.039	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	343.0	31.0	-0.198	0.037	1000.0	-1000.0	-0.047	-1000.0
IL12-mediated signaling events	10.0	931.0	87.0	-0.2	0.035	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	10.0	739.0	68.0	-0.101	0.043	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	10.0	71.0	7.0	-0.041	0.033	1000.0	-1000.0	-0.007	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	10.0	837.0	78.0	-0.149	0.066	1000.0	-1000.0	-0.058	-1000.0
BMP receptor signaling	9.0	764.0	81.0	-0.159	0.055	1000.0	-1000.0	-0.035	-1000.0
Glypican 1 network	9.0	458.0	48.0	-0.047	0.033	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	9.0	609.0	62.0	-0.147	0.069	1000.0	-1000.0	-0.036	-1000.0
S1P1 pathway	9.0	342.0	36.0	-0.19	0.032	1000.0	-1000.0	-0.035	-1000.0
IL27-mediated signaling events	9.0	503.0	51.0	-0.185	0.114	1000.0	-1000.0	-0.053	-1000.0
LPA receptor mediated events	9.0	933.0	102.0	-0.195	0.033	1000.0	-1000.0	-0.04	-1000.0
EGFR-dependent Endothelin signaling events	9.0	209.0	21.0	-0.069	0.045	1000.0	-1000.0	-0.026	-1000.0
Syndecan-2-mediated signaling events	8.0	561.0	69.0	-0.122	0.035	1000.0	-1000.0	-0.039	-1000.0
FAS signaling pathway (CD95)	8.0	386.0	47.0	-0.162	0.073	1000.0	-1000.0	-0.027	-1000.0
Syndecan-4-mediated signaling events	8.0	596.0	67.0	-0.075	0.032	1000.0	-1000.0	-0.042	-1000.0
amb2 Integrin signaling	7.0	650.0	82.0	-0.111	0.035	1000.0	-1000.0	-0.029	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	572.0	74.0	-0.092	0.052	1000.0	-1000.0	-0.058	-1000.0
Caspase cascade in apoptosis	6.0	513.0	74.0	-0.059	0.045	1000.0	-1000.0	-0.031	-1000.0
Arf6 signaling events	6.0	412.0	62.0	-0.07	0.068	1000.0	-1000.0	-0.012	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	400.0	65.0	-0.137	0.074	1000.0	-1000.0	-0.031	-1000.0
HIF-2-alpha transcription factor network	6.0	300.0	43.0	-0.063	0.051	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	6.0	316.0	51.0	-0.128	0.064	1000.0	-1000.0	-0.036	-1000.0
Glypican 2 network	6.0	26.0	4.0	-0.003	-0.0	1000.0	-1000.0	-0.0	-1000.0
IL6-mediated signaling events	6.0	521.0	75.0	-0.084	0.053	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	6.0	560.0	86.0	-0.074	0.047	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	0.002	0.028	1000.0	-1000.0	0.015	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	700.0	136.0	-0.405	0.083	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by PTP1B	5.0	404.0	76.0	-0.081	0.063	1000.0	-1000.0	-0.037	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	334.0	61.0	-0.128	0.062	1000.0	-1000.0	-0.039	-1000.0
Arf6 downstream pathway	5.0	256.0	43.0	-0.051	0.052	1000.0	-1000.0	-0.026	-1000.0
PDGFR-alpha signaling pathway	5.0	231.0	44.0	-0.114	0.05	1000.0	-1000.0	-0.041	-1000.0
Reelin signaling pathway	5.0	322.0	56.0	-0.081	0.083	1000.0	-1000.0	-0.034	-1000.0
TRAIL signaling pathway	5.0	282.0	48.0	-0.029	0.051	1000.0	-1000.0	-0.028	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	81.0	15.0	-0.032	0.032	1000.0	-1000.0	-0.032	-1000.0
Syndecan-3-mediated signaling events	5.0	180.0	35.0	-0.139	0.062	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	5.0	465.0	84.0	-0.113	0.068	1000.0	-1000.0	-0.042	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	238.0	45.0	-0.056	0.046	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	728.0	125.0	-0.037	0.039	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in the nascent adherens junction	5.0	404.0	76.0	-0.064	0.058	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	5.0	256.0	43.0	-0.033	0.045	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	4.0	372.0	76.0	-0.182	0.054	1000.0	-1000.0	-0.014	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	126.0	28.0	-0.023	0.042	1000.0	-1000.0	-0.013	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	-0.008	0.03	1000.0	-1000.0	-0.001	-1000.0
Visual signal transduction: Cones	4.0	161.0	38.0	-0.019	0.048	1000.0	-1000.0	-0.006	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	222.0	54.0	-0.057	0.047	1000.0	-1000.0	-0.037	-1000.0
p75(NTR)-mediated signaling	4.0	527.0	125.0	-0.118	0.074	1000.0	-1000.0	-0.042	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	186.0	46.0	-0.071	0.071	1000.0	-1000.0	-0.055	-1000.0
mTOR signaling pathway	4.0	220.0	53.0	-0.014	0.087	1000.0	-1000.0	-0.032	-1000.0
Ceramide signaling pathway	4.0	367.0	76.0	-0.054	0.06	1000.0	-1000.0	-0.028	-1000.0
IL2 signaling events mediated by PI3K	4.0	233.0	58.0	-0.094	0.033	1000.0	-1000.0	-0.047	-1000.0
Nongenotropic Androgen signaling	4.0	225.0	52.0	-0.071	0.06	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by STAT5	4.0	94.0	22.0	-0.074	0.033	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events	4.0	299.0	73.0	-0.034	0.037	1000.0	-1000.0	-0.042	-1000.0
VEGFR1 specific signals	4.0	271.0	56.0	-0.042	0.039	1000.0	-1000.0	-0.046	-1000.0
S1P3 pathway	4.0	175.0	42.0	-0.049	0.042	1000.0	-1000.0	-0.033	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	535.0	120.0	-0.141	0.082	1000.0	-1000.0	-0.042	-1000.0
Visual signal transduction: Rods	4.0	239.0	52.0	-0.075	0.047	1000.0	-1000.0	-0.025	-1000.0
Regulation of Androgen receptor activity	4.0	292.0	70.0	-0.215	0.053	1000.0	-1000.0	-0.046	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	70.0	17.0	-0.011	0.033	1000.0	-1000.0	-0.022	-1000.0
ErbB2/ErbB3 signaling events	3.0	220.0	65.0	-0.032	0.045	1000.0	-1000.0	-0.052	-1000.0
ErbB4 signaling events	3.0	266.0	69.0	-0.08	0.046	1000.0	-1000.0	-0.038	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	60.0	17.0	-0.013	0.047	1000.0	-1000.0	-0.03	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	18.0	5.0	0.012	0.033	1000.0	-1000.0	0.011	-1000.0
Cellular roles of Anthrax toxin	3.0	146.0	39.0	-0.051	0.032	1000.0	-1000.0	-0.023	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	333.0	85.0	-0.097	0.088	1000.0	-1000.0	-0.05	-1000.0
PLK1 signaling events	3.0	255.0	85.0	-0.023	0.1	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class III	3.0	156.0	40.0	-0.061	0.061	1000.0	-1000.0	-0.028	-1000.0
S1P5 pathway	3.0	61.0	17.0	-0.013	0.032	1000.0	-1000.0	-0.011	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	193.0	52.0	-0.026	0.077	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	3.0	201.0	58.0	-0.061	0.061	1000.0	-1000.0	-0.04	-1000.0
TCGA08_rtk_signaling	3.0	83.0	26.0	-0.063	0.063	1000.0	-1000.0	-0.006	-1000.0
Insulin Pathway	3.0	236.0	74.0	-0.048	0.081	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	338.0	88.0	-0.048	0.035	1000.0	-1000.0	-0.063	-1000.0
PDGFR-beta signaling pathway	3.0	322.0	97.0	-0.06	0.076	1000.0	-1000.0	-0.047	-1000.0
S1P4 pathway	3.0	88.0	25.0	-0.019	0.042	1000.0	-1000.0	-0.022	-1000.0
Aurora B signaling	3.0	236.0	67.0	-0.093	0.057	1000.0	-1000.0	-0.035	-1000.0
Aurora A signaling	2.0	138.0	60.0	-0.005	0.056	1000.0	-1000.0	-0.013	-1000.0
EPO signaling pathway	2.0	136.0	55.0	-0.014	0.057	1000.0	-1000.0	-0.046	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	110.0	37.0	-0.04	0.061	1000.0	-1000.0	-0.031	-1000.0
ceramide signaling pathway	2.0	143.0	49.0	-0.027	0.043	1000.0	-1000.0	-0.029	-1000.0
FoxO family signaling	2.0	167.0	64.0	-0.111	0.066	1000.0	-1000.0	-0.051	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	104.0	36.0	-0.048	0.062	1000.0	-1000.0	-0.034	-1000.0
Atypical NF-kappaB pathway	2.0	82.0	31.0	-0.007	0.033	1000.0	-1000.0	-0.022	-1000.0
Regulation of Telomerase	2.0	291.0	102.0	-0.095	0.08	1000.0	-1000.0	-0.034	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	92.0	33.0	-0.053	0.074	1000.0	-1000.0	-0.036	-1000.0
LPA4-mediated signaling events	1.0	23.0	12.0	-0.015	0.041	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	26.0	23.0	0.012	0.06	1000.0	-1000.0	-0.025	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	39.0	34.0	-0.04	0.064	1000.0	-1000.0	-0.025	-1000.0
BARD1 signaling events	1.0	63.0	57.0	-0.047	0.073	1000.0	-1000.0	-0.041	-1000.0
Circadian rhythm pathway	1.0	28.0	22.0	-0.01	0.048	1000.0	-1000.0	-0.051	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.0	-1000.0
Insulin-mediated glucose transport	1.0	43.0	32.0	-0.025	0.042	1000.0	-1000.0	-0.02	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	105.0	68.0	-0.044	0.065	1000.0	-1000.0	-0.032	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	158.0	82.0	-0.029	0.054	1000.0	-1000.0	-0.057	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	136.0	83.0	-0.025	0.059	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class I	1.0	161.0	104.0	-0.042	0.076	1000.0	-1000.0	-0.026	-1000.0
Regulation of p38-alpha and p38-beta	1.0	101.0	54.0	-0.007	0.075	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	1.0	91.0	71.0	-0.035	0.043	1000.0	-1000.0	-0.02	-1000.0
Rapid glucocorticoid signaling	1.0	20.0	20.0	-0.0	0.042	1000.0	-1000.0	-0.003	-1000.0
Signaling events mediated by PRL	1.0	54.0	34.0	-0.031	0.046	1000.0	-1000.0	-0.038	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.026	0.026	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	1.0	59.0	44.0	-0.017	0.06	1000.0	-1000.0	-0.021	-1000.0
Alternative NF-kappaB pathway	1.0	16.0	13.0	-0.0	0.074	1000.0	-1000.0	-0.0	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.0	0.067	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class II	0.0	68.0	75.0	-0.04	0.057	1000.0	-1000.0	-0.029	-1000.0
Aurora C signaling	0.0	1.0	7.0	-0.0	0.057	1000.0	-1000.0	-0.009	-1000.0
Effects of Botulinum toxin	0.0	20.0	26.0	-0.01	0.054	1000.0	-1000.0	-0.001	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	22.0	27.0	-0.0	0.063	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	0.0	22.0	54.0	-0.002	0.043	1000.0	-1000.0	-0.02	-1000.0
Total	778	49796	7203	-11.7497232648	7.61708459751	131000	-131000	-4.35905282516	-131000