PLK1 signaling events Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations regulation of centriole-centriole cohesion 0.012 0.057 0.178 53.0 -9999.0 0.0 53.0 BUB1B -0.028 0.1 -9999.0 0.0 -0.218 93.0 93.0 PLK1 -0.009 0.049 -9999.0 0.0 -0.104 94.0 94.0 PLK1S1 -0.003 0.022 0.027 4.0 -0.047 87.0 91.0 KIF2A -0.006 0.047 -9999.0 0.0 -0.108 77.0 77.0 regulation of mitotic centrosome separation -0.009 0.048 -9999.0 0.0 -0.104 94.0 94.0 GOLGA2 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 Hec1/SPC24 -0.015 0.088 -9999.0 0.0 -0.147 136.0 136.0 WEE1 -0.014 0.076 -9999.0 0.0 -0.179 71.0 71.0 cytokinesis -0.053 0.145 -9999.0 0.0 -0.311 112.0 112.0 PP2A-alpha B56 -0.036 0.237 -9999.0 0.0 -0.704 61.0 61.0 AURKA -0.025 0.09 -9999.0 0.0 -0.256 70.0 70.0 PICH/PLK1 -0.024 0.103 -9999.0 0.0 -0.171 147.0 147.0 CENPE -0.005 0.046 -9999.0 0.0 -0.107 73.0 73.0 RhoA/GTP 0.016 0.016 -9999.0 0.0 -0.135 6.0 6.0 positive regulation of microtubule depolymerization -0.006 0.047 -9999.0 0.0 -0.108 77.0 77.0 PPP2CA 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 FZR1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TPX2 -0.034 0.099 -9999.0 0.0 -0.255 90.0 90.0 PAK1 0.016 0.029 -9999.0 0.0 -0.123 23.0 23.0 SPC24 0.016 0.029 -9999.0 0.0 -0.122 24.0 24.0 FBXW11 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CLSPN 0.0 0.035 -9999.0 0.0 -0.177 7.0 7.0 GORASP1 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 metaphase -0.001 0.004 -9999.0 0.0 -0.014 32.0 32.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NLP -0.003 0.022 0.027 4.0 -0.047 87.0 91.0 G2 phase of mitotic cell cycle -0.001 0.003 -9999.0 0.0 -0.009 56.0 56.0 STAG2 0.02 0.02 -9999.0 0.0 -0.122 10.0 10.0 GRASP65/GM130/RAB1/GTP 0.017 0.031 -9999.0 0.0 -9999.0 0.0 0.0 spindle elongation -0.009 0.048 -9999.0 0.0 -0.104 94.0 94.0 ODF2 0.021 0.014 -9999.0 0.0 -0.124 5.0 5.0 BUB1 -0.063 0.248 -9999.0 0.0 -0.767 61.0 61.0 TPT1 0.001 0.035 -9999.0 0.0 -0.161 16.0 16.0 CDC25C -0.016 0.096 -9999.0 0.0 -0.37 34.0 34.0 CDC25B 0.015 0.025 -9999.0 0.0 -0.127 14.0 14.0 SGOL1 -0.012 0.057 -9999.0 0.0 -0.178 53.0 53.0 RHOA 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 CCNB1/CDK1 -0.028 0.13 -9999.0 0.0 -0.236 138.0 138.0 CDC14B 0.011 0.004 -9999.0 0.0 -0.085 1.0 1.0 CDC20 0.016 0.027 -9999.0 0.0 -0.122 19.0 19.0 PLK1/PBIP1 -0.003 0.042 -9999.0 0.0 -0.096 72.0 72.0 mitosis 0.003 0.009 0.026 63.0 -0.011 1.0 64.0 FBXO5 -0.019 0.07 -9999.0 0.0 -0.154 93.0 93.0 CDC2 0.007 0.04 -9999.0 0.0 -0.122 46.0 46.0 NDC80 0.008 0.038 -9999.0 0.0 -0.122 43.0 43.0 metaphase plate congression -0.0 0.042 -9999.0 0.0 -0.162 21.0 21.0 ERCC6L -0.033 0.124 -9999.0 0.0 -0.23 135.0 135.0 NLP/gamma Tubulin -0.002 0.029 -9999.0 0.0 -0.08 49.0 49.0 microtubule cytoskeleton organization 0.001 0.035 -9999.0 0.0 -0.16 16.0 16.0 G2/M transition DNA damage checkpoint -0.0 0.002 0.01 16.0 -9999.0 0.0 16.0 PPP1R12A 0.022 0.008 -9999.0 0.0 -0.122 1.0 1.0 interphase -0.0 0.002 0.01 16.0 -9999.0 0.0 16.0 PLK1/PRC1-2 -0.015 0.095 -9999.0 0.0 -0.171 121.0 121.0 GRASP65/GM130/RAB1/GTP/PLK1 0.024 0.053 -9999.0 0.0 -0.115 49.0 49.0 RAB1A 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 prophase -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Aurora A/BORA -0.011 0.051 -9999.0 0.0 -0.114 88.0 88.0 mitotic prometaphase -0.001 0.003 0.02 6.0 -0.01 24.0 30.0 proteasomal ubiquitin-dependent protein catabolic process 0.013 0.058 -9999.0 0.0 -0.23 18.0 18.0 microtubule-based process -0.01 0.072 -9999.0 0.0 -0.139 102.0 102.0 Golgi organization -0.009 0.048 -9999.0 0.0 -0.104 94.0 94.0 Cohesin/SA2 -0.003 0.054 -9999.0 0.0 -0.116 84.0 84.0 PPP1CB/MYPT1 0.024 0.039 -9999.0 0.0 -0.144 28.0 28.0 KIF20A 0.009 0.038 -9999.0 0.0 -0.122 43.0 43.0 APC/C/CDC20 -0.005 0.069 -9999.0 0.0 -0.128 101.0 101.0 PPP2R1A 0.022 0.009 -9999.0 0.0 -0.122 2.0 2.0 chromosome segregation -0.003 0.042 -9999.0 0.0 -0.095 72.0 72.0 PRC1 0.015 0.03 -9999.0 0.0 -0.122 25.0 25.0 ECT2 -0.021 0.072 -9999.0 0.0 -0.144 112.0 112.0 C13orf34 -0.01 0.05 -9999.0 0.0 -0.11 86.0 86.0 NUDC -0.0 0.042 -9999.0 0.0 -0.162 21.0 21.0 regulation of attachment of spindle microtubules to kinetochore -0.028 0.099 -9999.0 0.0 -0.216 93.0 93.0 spindle assembly -0.005 0.037 -9999.0 0.0 -0.08 86.0 86.0 spindle stabilization -0.003 0.022 0.027 4.0 -0.047 87.0 91.0 APC/C/HCDH1 0.025 0.007 -9999.0 0.0 -0.089 2.0 2.0 MKLP2/PLK1 -0.01 0.073 -9999.0 0.0 -0.14 102.0 102.0 CCNB1 0.014 0.028 -9999.0 0.0 -0.123 21.0 21.0 PPP1CB 0.022 0.003 -9999.0 0.0 -9999.0 0.0 0.0 BTRC 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ROCK2 -0.016 0.095 -9999.0 0.0 -0.327 42.0 42.0 TUBG1 -0.0 0.039 -9999.0 0.0 -0.173 18.0 18.0 G2/M transition of mitotic cell cycle -0.043 0.118 -9999.0 0.0 -0.232 138.0 138.0 MLF1IP 0.01 0.011 -9999.0 0.0 -0.079 8.0 8.0 INCENP 0.022 0.009 -9999.0 0.0 -0.122 2.0 2.0