Integrins in angiogenesis Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations VEGFR2 homodimer/VEGFA homodimer 0.019 0.049 -9999.0 0.0 -0.12 58.0 58.0 alphaV beta3 Integrin -0.001 0.073 -9999.0 0.0 -0.129 107.0 107.0 PTK2 -0.029 0.131 -9999.0 0.0 -0.273 92.0 92.0 IGF1R 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 PI4KB 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 MFGE8 0.006 0.043 -9999.0 0.0 -0.122 56.0 56.0 SRC 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 CDKN1B -0.006 0.085 -9999.0 0.0 -0.337 28.0 28.0 VEGFA 0.019 0.021 -9999.0 0.0 -0.122 11.0 11.0 ILK 0.013 0.04 -9999.0 0.0 -0.309 3.0 3.0 ROCK1 0.022 0.009 -9999.0 0.0 -0.122 2.0 2.0 AKT1 0.014 0.038 -9999.0 0.0 -0.283 3.0 3.0 PTK2B -0.011 0.063 -9999.0 0.0 -0.107 139.0 139.0 alphaV/beta3 Integrin/JAM-A 0.014 0.068 -9999.0 0.0 -0.101 114.0 114.0 CBL 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV beta3 Integrin/ANGPTL3 -0.001 0.073 -9999.0 0.0 -0.129 107.0 107.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.013 0.07 -9999.0 0.0 -0.108 107.0 107.0 VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.011 0.095 -9999.0 0.0 -0.248 51.0 51.0 alphaV/beta3 Integrin/Syndecan-1 -0.003 0.074 -9999.0 0.0 -0.129 113.0 113.0 PI4KA 0.021 0.016 -9999.0 0.0 -0.122 7.0 7.0 IGF-1R heterotetramer/IGF1/IRS1 -0.055 0.086 -9999.0 0.0 -0.164 152.0 152.0 PI4 Kinase 0.028 0.032 -9999.0 0.0 -0.118 24.0 24.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.122 7.0 7.0 alphaV/beta3 Integrin/Osteopontin -0.03 0.098 -9999.0 0.0 -0.161 164.0 164.0 RPS6KB1 -0.056 0.082 -9999.0 0.0 -0.157 163.0 163.0 TLN1 0.021 0.012 -9999.0 0.0 -0.122 3.0 3.0 MAPK3 -0.054 0.142 -9999.0 0.0 -0.338 102.0 102.0 GPR124 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 MAPK1 -0.055 0.144 -9999.0 0.0 -0.343 102.0 102.0 PXN 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.122 27.0 27.0 alphaV/beta3 Integrin/Tumstatin -0.001 0.073 -9999.0 0.0 -0.128 107.0 107.0 cell adhesion -0.03 0.097 -9999.0 0.0 -0.182 117.0 117.0 ANGPTL3 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 VEGFR2 homodimer/VEGFA homodimer/Src 0.033 0.044 -9999.0 0.0 -0.114 38.0 38.0 IGF-1R heterotetramer 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 Rac1/GDP 0.016 0.015 -9999.0 0.0 -0.147 5.0 5.0 TGFBR2 0.02 0.02 -9999.0 0.0 -0.122 11.0 11.0 ITGB3 0.004 0.047 -9999.0 0.0 -0.122 68.0 68.0 IGF1 0.007 0.045 -9999.0 0.0 -0.122 60.0 60.0 RAC1 0.023 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-matrix adhesion -0.001 0.073 -9999.0 0.0 -0.128 107.0 107.0 apoptosis 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 CD47 0.021 0.012 -9999.0 0.0 -0.122 3.0 3.0 alphaV/beta3 Integrin/CD47 -0.009 0.084 -9999.0 0.0 -0.145 124.0 124.0 VCL 0.021 0.013 -9999.0 0.0 -0.122 4.0 4.0 alphaV/beta3 Integrin/Del1 -0.03 0.083 -9999.0 0.0 -0.137 161.0 161.0 CSF1 0.013 0.033 -9999.0 0.0 -0.122 31.0 31.0 PIK3C2A -0.012 0.103 -9999.0 0.0 -0.355 41.0 41.0 PI4 Kinase/Pyk2 0.001 0.059 -9999.0 0.0 -0.142 49.0 49.0 VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.001 0.079 -9999.0 0.0 -0.118 139.0 139.0 FAK1/Vinculin -0.016 0.115 -9999.0 0.0 -0.227 95.0 95.0 alphaV beta3/Integrin/ppsTEM5 -0.001 0.073 -9999.0 0.0 -0.129 107.0 107.0 RHOA 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 VTN 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 BCAR1 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 FGF2 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 F11R 0.022 0.012 -9999.0 0.0 -0.119 3.0 3.0 alphaV/beta3 Integrin/Lactadherin -0.028 0.088 -9999.0 0.0 -0.142 170.0 170.0 alphaV/beta3 Integrin/TGFBR2 -0.006 0.079 -9999.0 0.0 -0.14 112.0 112.0 alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.015 0.075 -9999.0 0.0 -0.118 112.0 112.0 HSP90AA1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Talin -0.005 0.074 -9999.0 0.0 -0.125 124.0 124.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 FN1 -0.013 0.056 -9999.0 0.0 -0.122 114.0 114.0 alphaV/beta3 Integrin/Pyk2 -0.0 0.072 -9999.0 0.0 -0.156 49.0 49.0 SDC1 0.021 0.018 -9999.0 0.0 -0.122 9.0 9.0 VAV3 -0.012 0.074 -9999.0 0.0 -0.135 118.0 118.0 PTPN11 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 IRS1 0.019 0.023 -9999.0 0.0 -0.122 14.0 14.0 FAK1/Paxillin -0.014 0.114 -9999.0 0.0 -0.229 87.0 87.0 cell migration -0.011 0.108 -9999.0 0.0 -0.21 92.0 92.0 ITGAV 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 PI3K 0.006 0.083 -9999.0 0.0 -0.174 61.0 61.0 SPP1 0.012 0.032 -9999.0 0.0 -0.122 28.0 28.0 KDR 0.021 0.019 -9999.0 0.0 -0.122 10.0 10.0 mol:PI-4-5-P2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 alphaV/beta3 Integrin/Caspase 8 0.013 0.032 -9999.0 0.0 -0.122 28.0 28.0 COL4A3 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 angiogenesis -0.056 0.156 -9999.0 0.0 -0.37 102.0 102.0 Rac1/GTP -0.007 0.075 -9999.0 0.0 -0.183 54.0 54.0 EDIL3 -0.007 0.057 -9999.0 0.0 -0.122 109.0 109.0 cell proliferation -0.006 0.079 -9999.0 0.0 -0.14 112.0 112.0