IGF1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations NCK2 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 PTK2 0.021 0.016 -9999.0 0.0 -0.122 6.0 6.0 CRKL -0.005 0.054 -9999.0 0.0 -0.116 91.0 91.0 GRB2/SOS1/SHC 0.035 0.041 -9999.0 0.0 -0.117 30.0 30.0 HRAS 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 IRS1/Crk -0.001 0.057 -9999.0 0.0 -0.116 91.0 91.0 IGF-1R heterotetramer/IGF1/PTP1B 0.008 0.062 -9999.0 0.0 -0.116 89.0 89.0 AKT1 -0.01 0.06 -9999.0 0.0 -0.112 108.0 108.0 BAD -0.007 0.057 -9999.0 0.0 -0.104 108.0 108.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.005 0.054 -9999.0 0.0 -0.116 91.0 91.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.003 0.062 -9999.0 0.0 -0.119 105.0 105.0 RAF1 -0.004 0.092 -9999.0 0.0 -0.476 12.0 12.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos 0.01 0.07 -9999.0 0.0 -0.112 110.0 110.0 YWHAZ 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 -0.004 0.063 -9999.0 0.0 -0.132 91.0 91.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.122 7.0 7.0 RPS6KB1 -0.011 0.063 -9999.0 0.0 -0.117 110.0 110.0 GNB2L1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of MAPKKK cascade -0.007 0.079 0.196 7.0 -0.379 12.0 19.0 PXN 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.122 27.0 27.0 cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1 0.021 0.045 -9999.0 0.0 -0.117 50.0 50.0 HRAS/GTP -0.002 0.052 -9999.0 0.0 -0.101 89.0 89.0 IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc 0.022 0.068 -9999.0 0.0 -0.118 46.0 46.0 IGF-1R heterotetramer 0.012 0.033 -9999.0 0.0 -0.093 41.0 41.0 IGF-1R heterotetramer/IGF1/IRS/Nck 0.008 0.062 -9999.0 0.0 -0.117 91.0 91.0 Crk/p130 Cas/Paxillin 0.021 0.06 -9999.0 0.0 -0.099 86.0 86.0 IGF1R 0.012 0.033 -9999.0 0.0 -0.093 41.0 41.0 IGF1 0.001 0.047 -9999.0 0.0 -0.076 124.0 124.0 IRS2/Crk 0.004 0.054 -9999.0 0.0 -0.107 87.0 87.0 PI3K 0.0 0.076 -9999.0 0.0 -0.114 147.0 147.0 apoptosis -0.003 0.057 0.118 59.0 -9999.0 0.0 59.0 HRAS/GDP 0.017 0.008 -9999.0 0.0 -0.112 2.0 2.0 PRKCD -0.015 0.093 -9999.0 0.0 -0.196 93.0 93.0 RAF1/14-3-3 E 0.007 0.084 -9999.0 0.0 -0.405 12.0 12.0 BAD/14-3-3 0.003 0.06 -9999.0 0.0 -0.124 59.0 59.0 PRKCZ -0.009 0.059 -9999.0 0.0 -0.11 107.0 107.0 Crk/p130 Cas/Paxillin/FAK1 0.004 0.069 -9999.0 0.0 -0.151 55.0 55.0 PTPN1 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.016 0.095 -9999.0 0.0 -0.207 89.0 89.0 BCAR1 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 IGF-1R heterotetramer/IGF1/SHC/GRB10 0.019 0.061 -9999.0 0.0 -0.095 95.0 95.0 mol:GDP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SOS1 0.017 0.027 -9999.0 0.0 -0.122 20.0 20.0 IRS1/NCK2 0.002 0.058 -9999.0 0.0 -0.117 91.0 91.0 GRB10 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 PTPN11 -0.006 0.057 -9999.0 0.0 -0.122 92.0 92.0 IRS1 -0.011 0.058 -9999.0 0.0 -0.132 91.0 91.0 IRS2 -0.005 0.054 -9999.0 0.0 -0.115 92.0 92.0 IGF-1R heterotetramer/IGF1 -0.012 0.076 -9999.0 0.0 -0.165 91.0 91.0 GRB2 0.023 0.006 -9999.0 0.0 -0.122 1.0 1.0 PDPK1 -0.011 0.064 -9999.0 0.0 -0.109 141.0 141.0 YWHAE 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 PRKD1 -0.021 0.097 -9999.0 0.0 -0.207 98.0 98.0 SHC1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0