Cellular roles of Anthrax toxin Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations ANTXR1 0.007 0.043 -9999.0 0.0 -0.122 54.0 54.0 ANTXR2 0.013 0.036 -9999.0 0.0 -0.122 36.0 36.0 negative regulation of myeloid dendritic cell antigen processing and presentation -0.007 0.013 -9999.0 0.0 -0.034 102.0 102.0 monocyte activation -0.1 0.16 -9999.0 0.0 -0.354 156.0 156.0 MAP2K2 0.006 0.052 -9999.0 0.0 -0.658 3.0 3.0 MAP2K1 -0.0 0.015 -9999.0 0.0 -0.031 80.0 80.0 MAP2K7 -0.0 0.014 -9999.0 0.0 -0.028 105.0 105.0 MAP2K6 -0.005 0.024 -9999.0 0.0 -0.041 132.0 132.0 CYAA -0.016 0.048 -9999.0 0.0 -0.108 102.0 102.0 MAP2K4 -0.001 0.016 -9999.0 0.0 -0.029 105.0 105.0 IL1B -0.009 0.035 -9999.0 0.0 -0.073 94.0 94.0 Channel -0.003 0.06 -9999.0 0.0 -0.098 144.0 144.0 NLRP1 -0.001 0.015 -9999.0 0.0 -0.032 81.0 81.0 CALM1 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 negative regulation of phagocytosis 0.001 0.054 -9999.0 0.0 -0.455 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of endothelial cell proliferation 0.007 0.013 0.034 102.0 -9999.0 0.0 102.0 MAPK3 -0.001 0.015 -9999.0 0.0 -0.031 83.0 83.0 MAPK1 -0.001 0.019 -9999.0 0.0 -0.033 108.0 108.0 PGR -0.011 0.027 -9999.0 0.0 -0.044 195.0 195.0 PA/Cellular Receptors -0.004 0.066 -9999.0 0.0 -0.11 144.0 144.0 apoptosis -0.007 0.013 -9999.0 0.0 -0.034 102.0 102.0 LOC728358 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Lethal toxin (unfolded) -0.002 0.058 -9999.0 0.0 -0.115 102.0 102.0 macrophage activation 0.003 0.018 -9999.0 0.0 -0.053 29.0 29.0 TNF 0.02 0.02 -9999.0 0.0 -0.122 11.0 11.0 VCAM1 -0.1 0.161 -9999.0 0.0 -0.356 156.0 156.0 platelet activation 0.001 0.054 -9999.0 0.0 -0.455 7.0 7.0 MAPKKK cascade 0.003 0.02 0.048 52.0 -9999.0 0.0 52.0 IL18 -0.011 0.039 -9999.0 0.0 -0.076 110.0 110.0 negative regulation of macrophage activation -0.007 0.013 -9999.0 0.0 -0.034 102.0 102.0 LEF -0.007 0.013 -9999.0 0.0 -0.034 102.0 102.0 CASP1 -0.005 0.024 -9999.0 0.0 -0.043 106.0 106.0 mol:cAMP 0.001 0.055 -9999.0 0.0 -0.459 7.0 7.0 necrosis -0.007 0.013 -9999.0 0.0 -0.034 102.0 102.0 intracellular pH reduction -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PAGA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Edema toxin (unfolded) -0.001 0.056 -9999.0 0.0 -0.091 144.0 144.0 mol:Epigallocatechin-3-gallate (EGCG) -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0