Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.083 0.188 -9999.0 0.0 -0.399 135.0 135.0 IHH -0.002 0.048 -9999.0 0.0 -0.076 141.0 141.0 SHH Np/Cholesterol/GAS1 0.023 0.028 -9999.0 0.0 -0.098 16.0 16.0 LRPAP1 0.018 0.024 -9999.0 0.0 -0.122 15.0 15.0 dorsoventral neural tube patterning -0.022 0.028 0.097 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.01 0.106 -9999.0 0.0 -0.29 9.0 9.0 SMO -0.018 0.107 -9999.0 0.0 -0.3 9.0 9.0 AKT1 -0.017 0.112 -9999.0 0.0 -0.332 39.0 39.0 ARRB2 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 BOC 0.011 0.039 -9999.0 0.0 -0.122 44.0 44.0 ADRBK1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 STIL -0.016 0.082 -9999.0 0.0 -0.217 16.0 16.0 DHH N/PTCH2 0.034 0.011 -9999.0 0.0 -0.09 4.0 4.0 DHH N/PTCH1 -0.019 0.099 -9999.0 0.0 -0.179 135.0 135.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.122 7.0 7.0 DHH 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 PTHLH -0.072 0.179 -9999.0 0.0 -0.376 135.0 135.0 determination of left/right symmetry -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.122 27.0 27.0 skeletal system development -0.072 0.178 -9999.0 0.0 -0.374 135.0 135.0 IHH N/Hhip 0.016 0.039 -9999.0 0.0 -0.111 17.0 17.0 DHH N/Hhip 0.029 0.024 -9999.0 0.0 -0.073 28.0 28.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 pancreas development 0.017 0.029 -9999.0 0.0 -0.122 24.0 24.0 HHAT 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 PI3K 0.007 0.065 -9999.0 0.0 -0.128 96.0 96.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.035 -9999.0 0.0 -0.122 35.0 35.0 somite specification -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.013 0.087 -9999.0 0.0 -0.152 135.0 135.0 SHH Np/Cholesterol/PTCH2 0.03 0.012 -9999.0 0.0 -0.101 3.0 3.0 SHH Np/Cholesterol/Megalin 0.007 0.039 -9999.0 0.0 -0.098 20.0 20.0 SHH 0.022 0.011 -9999.0 0.0 -0.086 5.0 5.0 catabolic process -0.033 0.109 -9999.0 0.0 -0.21 135.0 135.0 SMO/Vitamin D3 -0.01 0.097 -9999.0 0.0 -0.237 9.0 9.0 SHH Np/Cholesterol/Hhip 0.027 0.019 -9999.0 0.0 -0.099 3.0 3.0 LRP2 -0.016 0.064 -9999.0 0.0 -0.122 148.0 148.0 receptor-mediated endocytosis -0.02 0.098 -9999.0 0.0 -0.275 8.0 8.0 SHH Np/Cholesterol/BOC 0.02 0.033 -9999.0 0.0 -0.103 23.0 23.0 SHH Np/Cholesterol/CDO 0.018 0.036 -9999.0 0.0 -0.098 36.0 36.0 mesenchymal cell differentiation -0.027 0.019 0.099 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.011 0.088 -9999.0 0.0 -0.152 135.0 135.0 IHH N/PTCH2 0.021 0.032 -9999.0 0.0 -0.131 4.0 4.0 CDON 0.013 0.035 -9999.0 0.0 -0.122 35.0 35.0 IHH N/PTCH1 -0.028 0.114 -9999.0 0.0 -0.212 135.0 135.0 Megalin/LRPAP1 -0.011 0.065 -9999.0 0.0 -0.093 200.0 200.0 PTCH2 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 SHH Np/Cholesterol 0.018 0.009 -9999.0 0.0 -0.105 2.0 2.0 PTCH1 -0.033 0.109 -9999.0 0.0 -0.211 135.0 135.0 HHIP 0.017 0.029 -9999.0 0.0 -0.122 24.0 24.0